Incidence of Aphakic Cystoid Macular Edema with the Use of Topical Indomethacin

Yannuzzi, Lawrence A.; Landau, Arthur N.; Turtz, Arnold I.

doi:10.1016/s0161-6420(81)80010-3

Cited by 106 publications

(18 citation statements)

References 23 publications

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“…Although the efficacy of NSAIDs in minimizing complications after ocular surgery has been described, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]26,28,29 their effectiveness has not been adequately compared with that of betamethasone. 23 Topical indomethacin was the first NSAID confirmed to block miosis during aspiration of soft cataracts 29 and to prevent CME after intracapsular cataract extraction.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] One approach to preventing the negative effects of these mediators is to treat eyes with CME using nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit PG synthesis. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] Although systematic reviews acknowledge there is convincing clinical evidence that NSAIDs are effective in preventing and treating CME, they also indicate that further studies are warranted as previous studies had shortcomings involving the design and the length of the observation period. 23,24 The rate of CME differs depending on the surgical technique used.…”

mentioning

confidence: 99%

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Reducing angiographic cystoid macular edema and blood–aqueous barrier disruption after small-incision phacoemulsification and foldable intraocular lens implantation

Asano

Miyake²,

Ota³

et al. 2008

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Reducing angiographic cystoid macular edema and blood–aqueous barrier disruption after small-incision phacoemulsification and foldable intraocular lens implantation

Asano

Miyake²,

Ota³

et al. 2008

Journal of Cataract and Refractive Surgery

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“…Topical administration of NSAIDs has been shown to reach sufficient levels to achieve a decrease in angiographically proven cystoid macular edema, but no sustained effect on cystoid macular edema has been reported [37,38]. Furthermore, systemic administration of NSAIDs can cause severe dose-dependent side effects, including internal bleeding and gastrointestinal inflammation and ulcers.…”

Section: Introductionmentioning

confidence: 99%

Ocular Delivery of Acetylsalicylic Acid by Repetitive Coulomb-Controlled Iontophoresis

et al. 2003

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To investigate the potential of transscleral coulomb-controlled iontophoresis (CCI) for repetitive delivery of acetylsalicylic acid (ASA) into the eye, a total of 50 rabbits was included in this study. Fourteen animals received serial CCI treatment. Fourteen animals underwent CCI with either ASA or balanced salt solution (BSS) for at least 6 days at 24- and 48-hour intervals. Eighteen animals received a single CCI application, while 18 animals were injected with 15 mg ASA/kg body weight intravenously. HPLC analysis was performed to determine the levels of salicylic acid (SA) in ocular tissues. Apart from clinical follow-up, 2 rabbits in the ASA and BSS groups were examined by electroretinography, and 2 animals were examined histologically. Though high concentrations of SA were measured, no alterations were observed clinically, histologically and electrophysiologically. Repetitive CCI demonstrated its potential as a topical drug delivery system for ASA into the eye. This transscleral delivery of ASA resulted in significant and sustained intraocular concentrations of SA without side effects. Iontophoresis may be advantageous in clinical administration maintaining therapeutic levels of ASA while avoiding adverse effects associated with the systemic administration of nonsteroidal anti-inflammatory drugs.

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“…Some reports indicate that the use of topical NSAIDs produces a substantial reduction in the incidence of aphakic or pseudophakic macular edema. [3][4][5][6] Aspirin was ineffective in preventing CME in pseudophakic eyes. 7 Today, conventional NSAIDs are widely used in treating clinically evident macular edema.…”

mentioning

confidence: 99%