Incidence of acute kidney injury after intravenous administration of iodixanol for computed tomographic angiography

Schmalfuss, Carsten; Woodard, Pamela K.; Gitter, Michael J.; Jadhav, Manoj P.; Bellinger, Raye L.; Rose, Steven C.; Bavry, Anthony A.

doi:10.1016/j.ijcard.2014.08.054

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature describing the incidence of contrast-induced AKI or nephropathy in patients with acute ischemic stroke estimates a 2% incidence of AKI, whereas a decrease in serum creatinine can be seen in roughly 1% of patients. [27][28][29][30] The absence of an association between these interventions and AKI may be due to selection bias or insufficient exposure within the study cohort. Further study is needed to definitively determine if they are as harmful in this population as they are in others.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Erdman

Riha

Bode

et al. 2016

The Neurohospitalist

View full text Add to dashboard Cite

Background and Purpose: Continuous intravenous 3% hypertonic saline (HTS) infusions are commonly used for the management of cerebral edema following severe neurologic injuries. Despite widespread use, data regarding the incidence and predictors of nephrotoxicity are lacking. The purpose of this study was to describe the incidence and identify predictors of acute kidney injury (AKI) in neurocritical care patients administered continuous infusion HTS. Methods: This was an institutional review board-approved, multicenter, retrospective cohort study of patients receiving HTS infusions at 2 academic medical centers. A univariate analysis and multivariable logistic regression were used to identify predictors of AKI. Data regarding AKI were evaluated during treatment with HTS and up to 24 hours after discontinuation. Results: A total of 329 patients were included in our analysis, with 54 (16%) developing AKI. Those who developed AKI experienced significantly longer stays in the intensive care unit (14.8 vs 11.5 days; P ¼ .006) and higher mortality (48.1% vs 21.9%; P < .001). We identified past medical history of chronic kidney disease (odds ratio [OR]: 9.7, 95% confidence interval [CI]: 1.9-50.6; P ¼ .007), serum sodium greater than 155 mmol/L (OR: 4.1, 95% CI: 2.1-8.0; P < .001), concomitant administration of piperacillin/tazobactam (OR: 3.9, 95% CI: 1.7-9.3; P ¼ .002), male gender (OR: 3.2, 95% CI: 1.5-6.6; P ¼ .002), and African American race (OR: 2.6, 95% CI: 1.3-5.2; P ¼ .007) as independent predictors of AKI. Conclusion: Acute kidney injury is relatively common in patients receiving continuous HTS and may significantly impact clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Erdman

Riha

Bode

et al. 2016

The Neurohospitalist

View full text Add to dashboard Cite

show abstract

“…From the comparison of the UV results the intensities of these five targets were changed little from that of individual iohexol unlike the obvious change when the ratio of iohexol to Mg 2+ was 1:1, which means the Mg 2+ prefers to have one complexation with iohexol in the liquid phase. This phenomenon is different from that in the gas phase.CONCLUSIONSIn summary, the Mg 2+ /iohexol complexes investigated by ESI-MS 2 display a new type of metal ion-ligand complexes: [2(iohexol) + Mg] 2+ in the gas phase and the special loss of C3 H 4 O under CID. Deuterium-labeling experiments and dissociation of the iohexol analogue indicate that the Mg 2+ ion could interact with two iohexols to form the [2(iohexol) + Mg] 2+ ion.…”

mentioning

confidence: 92%

“…Iodinated X-ray contrast mediums such as iohexol have been widely used as the contrast agents for coronary angiography. [1][2][3] However, several adverse effects caused by these contrast agents still happen sometimes in clinical application, including allergic-type reactions, extravasations and renal toxicity. [4][5][6] The chemotoxicity of the contrast medium frequently comes from the stability of the organic iodine.…”

mentioning

confidence: 99%

Investigation of the formation of the [2(iohexol) + Mg]²⁺ complex and its fragmentation in electrospray ionization tandem mass spectrometry

Guo

Yin

Han

et al. 2016

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Rationale Mass spectrometry has been developed as one of the common tools for the analysis of the organometallic systems in the gas phase over decades. The study of the fragmentation of organics‐metal complexes has attracted much attention since the interesting dissociation pathways exhibited by these compounds are usually different from the protonated analogues. Methods In this work, iohexol complexed with different dications such as Mg2+, Cu2+ and Zn2+ have been investigated by electrospray ionization (ESI) tandem mass spectrometry. Additionally, deuterium‐labeling experiments and an analogue of iohexol were utilized to confirm the reaction mechanisms. A computational chemistry method was used to identify the coordination conformation between iohexol and metal ions in the gas phase. UV detection was also used to identify the interaction between iohexol and metal ions in the liquid phase. Results A special gas‐phase open‐loop reaction of iohexol induced by Mg2+, leading to the formation of [iohexol + Mg – H – HI ‐ C3H4O]+, was observed in the collision‐induced dissociation of [2(iohexol) + Mg]2+ complexes. Moreover, theoretical calculation shows the proposed coordination configuration of iohexol/Mg2+ complexes. The Mg2+ could have tetrahedral coordination with two iohexol molecules. Conclusions The percent study is a case for better understanding the formation of a typical organic/metal complex and its gas‐phase fragmentation reaction. In addition, it provides useful information for researchers working on analysis or structural elucidation of complicated compounds which contain the iohexol analogues. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Lower extremity CT angiograms and their effect on kidney function in orthopedic trauma patients

Asghar

Howard

Shelton

et al. 2021

Injury

View full text Add to dashboard Cite

Incidence of acute kidney injury after intravenous administration of iodixanol for computed tomographic angiography

Cited by 3 publications

References 9 publications

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Investigation of the formation of the [2(iohexol) + Mg]²⁺ complex and its fragmentation in electrospray ionization tandem mass spectrometry

Lower extremity CT angiograms and their effect on kidney function in orthopedic trauma patients

Contact Info

Product

Resources

About

Incidence of acute kidney injury after intravenous administration of iodixanol for computed tomographic angiography

Cited by 3 publications

References 9 publications

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Predictors of Acute Kidney Injury in Neurocritical Care Patients Receiving Continuous Hypertonic Saline

Investigation of the formation of the [2(iohexol) + Mg]2+ complex and its fragmentation in electrospray ionization tandem mass spectrometry

Lower extremity CT angiograms and their effect on kidney function in orthopedic trauma patients

Contact Info

Product

Resources

About

Investigation of the formation of the [2(iohexol) + Mg]²⁺ complex and its fragmentation in electrospray ionization tandem mass spectrometry