Incidence of Abnormal Corpus Luteum in Superovulated Ewes

Okada, Aki; Kamada, Syuhei; Jeon, C. G.; Miyamoto, Akio; Fukui, Yutaka

doi:10.1262/jrd.46.397

Cited by 19 publications

(18 citation statements)

References 23 publications

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“…We observed abnormal CL and a short cycle in the treatment phase during both seasons. This result is similar to that reported by Okada et al [21]. The present study has shown that the P 4 in two goats showing the short cycle decreased to basal levels (0.28 ng/ml) on day 4.…”

Section: Discussionsupporting

confidence: 93%

Luteal lifespan and fertility after estrus synchronization in goats

et al. 2008

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The present experiment aims to examine the efficiency of estrus synchronization using progesterone and equine chorionic gonadotrophin (eCG) and to look at luteal function. During the non-breeding and breeding season, 5 adult female Korean native goats were injected intramuscularly with 2.5 ml of physiological saline as the control. A progesterone impregnated intravaginal sponge was then kept in the same goats for 10 days followed, after a week, by an intramuscular injection of 500 IU eCG. Five adult female Nubian goats were mated with a fertile buck during the non-breeding season. During the non-breeding season 2 of the 5 goats showed a normal estrous cycle (ranging from 18 to 21 days) and 3 a short estrous cycle (ranging from 3 to 6 days). During the breeding season the equivalent figures were 1 and 2. The major axes of the corpus luteum (CL) were measured by means of calipers built into the ultrasonography system, and the concentrations of plasma progesterone (P4) were determined by double antibody radioimmunoassay. The mean major axes of the CL in goats showing the short cycle (6.1 ± 0.5 mm) was significantly smaller than in those showing the normal cycle (8.9 ± 0.5 mm; p < 0.01) and also the value of P4 in goats showing the short cycle (4.2 ± 2.1 ng/ml) was significantly lower than for those showing the normal cycle (10.3 ± 4.3 ng/ml; p < 0.05) at day 3 following ovulation. Three out of 5 Nubian goats became pregnant but only one goat carried to full term. The present experiment indicated that a combination of progesterone and eCG was effective in inducing estrus, although it resulted in a high incidence of short luteal lifespan. The low kidding rate and high incidence of embryonic loss may be due to the instability of the luteal lifespan.

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Section: Discussionsupporting

confidence: 93%

Luteal lifespan and fertility after estrus synchronization in goats

et al. 2008

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“…It is suggested that the use of higher doses of FSH may lead to the persistence of luteinized anovulatory follicles, which continue to produce oestrogen during the early luteal phase and promote the early release of PGF2α and luteal regression (Okada et al, ). However, in the present study no greater number of anovulatory follicles were observed in the G200 in relation to the other groups.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Because, high doses of FSH may induce changes in ovarian and/or endocrine dynamics (Kafi & McGowan, ) and on LH pulses, increasing the incidence of PRCL (Bevers, Dieleman, Blankestein, Tol, & Broek, ; Oliveira et al, ) besides being more expensive (Loiola Filho et al, ). Furthermore, higher doses may maintain the stimulus of the luteinized anovulatory follicles for longer periods, so these follicles are still producing oestrogen in the early luteal phase, causing persistence of high concentrations of this hormone, providing the early release of PGF2α and thus premature luteal regression (Okada et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, higher doses may maintain the stimulus of the luteinized anovulatory follicles for longer periods, so these follicles are still producing oestrogen in the early luteal phase, causing persistence of high concentrations of this hormone, providing the early release of PGF2α and thus premature luteal regression (Okada et al, 2000).…”

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confidence: 99%

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Early luteal development in Santa Inês ewes superovulated with reduced doses of porcine follicle‐stimulating hormone

Rodriguez

Maciel

Uscátegui

et al. 2018

Reprod Domestic Animals

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Contents The aim was to compare the early luteal development in ewes superovulated with different doses of pFSH. Twenty‐nine Santa Inês ewes received a progesterone device (CIDR®) for 8 days. Gonadotrophic treatment started on Day 6: G200 (control, n = 9, 200 mg); G133 (n = 10, 133 mg); and G100 (n = 10, 100 mg of pFSH). On Day 6, all females received eCG (300 IU). B‐mode and spectral Doppler ultrasonography were performed daily during the early luteal phase (Days 11–15) to monitor the development of corpora lutea (CLs; dimensions) and ovarian arteries indices. CLs were also classified as normal or prematurely regressed (PRCL) on Day 15 by videolaparoscopy. Ewes from G100 and G133 showed gradual increase in luteal diameter during the early luteal phase (p < 0.001), whereas G200 animals presented increase from Day 11 to Day 13, and then decrease on Days 14 and 15 (p < 0.001). The G200 females showed greater percentage of PRCL (45.20%) than those of the other groups (p < 0.001). The normal CLs number was greater in G100 than in G133 (p = 0.04), while the PRCL number was greater in G200 than in the other groups (p = 0.03). Resistive index (RI) was greater in G200 than in G100 (p = 0.02). RI was lower in Day 12 than Day 15 (p = 0.02). Pulsatility index (PI) was greater on Days 14 and 15 (p < 0.01). In conclusion, the lowest dose of pFSH (100 mg) can be considered sufficient for an efficient superovulatory response in sheep, producing better CLs development dynamic in early luteal phase and ovarian blood perfusion and smaller number of PRCL than the traditional (200 mg) pFSH dose.

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