Incidence, characteristics and prognosis of acute kidney injury in Cameroon: a prospective study at the Douala General Hospital

Halle, Marie Patrice; Chipekam, Ndjifoum Moselle; Béyiha, G; Fouda, Hermine; Coulibaly, Aminata; Hentchoya, Romuald; Kaze, F.; Luma, Namme Henry; Ashuntantang, Gloria

doi:10.1080/0886022x.2017.1419970

Cited by 34 publications

(46 citation statements)

References 45 publications

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“…Yearly, acute kidney injury (AKI), a sudden deterioration in kidney function, affects more than 13 million people globally leading to almost 2 million deaths. [1][2][3] Almost 80% of the AKI burden occurs in low-and middle-income countries (LMIC). 1,3 The incidence of AKI varies according to geographical location, etiological factors, and health resources; however, AKI is significantly higher in LMIC such as sub-Saharan Africa (SSA) 1 and is linked with longer hospital stay, higher hospital, and mortality.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID

Banda

Chenga

Nambaya

et al. 2020

Indian Journal of Critical Care Medicine

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Background and aims: Despite the increased rates of acute kidney injury (AKI) in intensive care units (ICU) and associated mortality, information on the epidemiology of AKI is sparse in sub-Saharan Africa (SSA). We investigated the rates and predictors of AKI and associated mortality in a tertiary ICU. Materials and methods: This retrospective study analyzed 280 hospital records of patients admitted to the ICU at a tertiary teaching hospital who were aged ≥15 years from January 2017 to May 31, 2018. The outcome parameters of the study were rates of AKI in the ICU, associated risk factors, and mortalities. Acute kidney injury and ICU mortality were established by the multivariate logistic analysis. Results: The median age was 36 years (IQR 28, 52). The rate of AKI was 52.9%, and the presence of human immunodeficiency virus (HIV) and oliguria was 2.3-fold (0.004) and 4-fold (0.016) positive predictors of ICU-AKI, respectively. Male gender (0.003), diabetes mellitus (DM) (0.010), respiratory disease (0.001), inotropes (0.004), and ventilator support (0.017) were predictors for ICU mortality after controlling for confounders. Conclusion:The rate of AKI is significantly higher in a referral tertiary hospital in Zambia compared to developed countries and the presence of HIV and noncommunicable diseases such as DM impacts severely on outcomes.

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Section: Introductionmentioning

confidence: 99%

Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID

Banda

Chenga

Nambaya

et al. 2020

Indian Journal of Critical Care Medicine

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“…Among AKI patients, the RRT rate was 13% in our study. Other studies reported RRT rates of 7.3% 23 , 10.2% 22 and 36.5% 8 . The need for RRT is one of the main complications of AKI and has a strong association with failed recovery of renal function and a high mortality rate; many aspects of RRT have sparked controversy 28 .…”

Section: Discussionmentioning

confidence: 95%

“…In a single-centre prospective study, Halle et al . 23 analysed 2,402 critically ill African patients, and the overall incidence of AKI according to the KDIGO criteria was 22.3%.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors of acute kidney injury in critically ill patients from a single centre in Brazil: a retrospective cohort analysis

Santos

Carvalho

Peres

2019

Sci Rep

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Studies with a comprehensive analysis of the epidemiology of acute kidney injury (AKI) in intensive care units (ICUs) are still limited in developing countries. The aim of this study is to identify the incidence and risk factors of AKI in critically ill patients from a Brazilian ICU. We performed a retrospective analysis of the records of patients admitted to a single-centre adult ICU in Brazil between 1 January 2011 and 31 December 2016. The KDIGO criteria were used to define AKI. Univariate and multivariate data analyses were carried out. We included 1,500 patients. The incidence of AKI was 40.5%, and the AKI dialysis rate was 13%. The predictors of AKI at ICU admission included hypertension [odds ratio (OR) = 1.44, p 0.017], high serum creatinine concentration [OR = 3.54; p < 0.001], low serum albumin concentration [OR = 1.42, p 0.015], high APACHE II score [OR = 2.10; p < 0.001] and high SAPS 3 [OR = 1.75; p < 0.001]. The incidence of AKI was high, and we identified the predictors of AKI among critically ill Brazilian patients. The results of this study may contribute to the implementation of targeted therapies.

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“…Nephrotoxic AKI was observed in 14.5% of the elderly and was mainly due to use of aminoglycoside and herbal remedies. Nephrotoxicity is linked to 10% -20% of AKI in Cameroonian studies [14] [15] [23]. However, Yao et al, found a lower frequency of nephrotoxic AKI in the elderly (2.8% vs 17%) compared to young adults [11].…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Outcome of Acute Kidney Injury in Elderly Adults in a Tertiary Hospital in Cameroon

Danielle¹,

Berinyuy²,

Mahamat³

et al. 2020

OJNeph

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Background: Elderly patients have a high risk of acute Kidney Injury (AKI) due to aging, decreased renal function and the presence of comorbidities. There is limited data on AKI in elderly patients in low income regions, especially in Sub-Saharan Africa. We therefore sought to describe the clinical profile and outcome of AKI in elderly in a tertiary hospital in Cameroon. Methods and Materials: We reviewed the medical records of all patients admitted with the diagnosis of AKI in the internal medicine unit of the Yaounde University Teaching Hospital, from January 2015 to February 2018. Records of elderly patients (≥65 years) were retrieved and analysed. AKI was diagnosed and classified using the KDIGO (Kidney Disease Improving Global Outcomes) 2012 classification. The diagnosis, aetiologies and mechanisms of AKI were clinical. Renal outcomes were evaluated on day 7, 14, 28, 60 and 90 of hospital stay. Results: We included 76 elderly (66% males) patients with a median [interquartile rate-IQR] age of 69 [65-75] years. Hypertension (60.5%), diabetes mellitus (36.8%) and heart failure (26.3%) were the most common comorbidities. The median [IQR] Charlson index was 4 [3-5]. Infections (47.4%) and hypovolemia (69.7%) were the most frequent risk factors for AKI. AKI was mainly community acquired (89.5%) and most of the patients were in stage 2 (34.2%) or 3 (29%). Pre-renal AKI (58%) was the leading mechanism involved. Hypovolemia and sepsis were the most common aetiologies. Of the 14.5% with indication for dialysis, only 2.6% had access to it. The overall prognosis was good with a mortality rate of 2.6%, complete and partial renal recovery at 3 months of 70%, and 26.

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Incidence, characteristics and prognosis of acute kidney injury in Cameroon: a prospective study at the Douala General Hospital

Cited by 34 publications

References 45 publications

Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID

Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID

Incidence and risk factors of acute kidney injury in critically ill patients from a single centre in Brazil: a retrospective cohort analysis

Clinical Profile and Outcome of Acute Kidney Injury in Elderly Adults in a Tertiary Hospital in Cameroon

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