Incidence, Characteristics, and Outcome of COVID-19 in Adults on Kidney Replacement Therapy: A Regionwide Registry Study

Meester, Johan De; Bacquer, Dirk De; Naesens, Maarten; Meijers, Björn; Couttenye, Marie M.; Vriese, An S. De

doi:10.1681/asn.2020060875

Cited by 125 publications

(144 citation statements)

References 36 publications

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“…The 50% rate of admission of our patients was lower than other countries. In the Dutch-speaking Belgian Renal Society patients, 138 out of 228 patients (60%) were admitted [18]. In the French series, 41 out of 44 patients (93%) were admitted although only thirty-three needed oxygen therapy [14].…”

Section: Discussionmentioning

confidence: 99%

“…In the largest Chinese sample from Wuhan, death rate was estimated at 20% [13]. The Paris Region, Japan, the UK Renal Registry, the Scottish Renal Registry, the Belgian Society of Nephrology, Brazil, Germany, Italy, Spain and New York reported death rates in hemodialysis of 27.3%, 16% (at one week), 12.5%, 26.7%, 29.6%, 27.7%, 26.8%, 32%, 20% and 27% respectively [14][15][16][17][18][19][20][21][22][23]. Recently, the largest two studies conducted in Europe, the ERACODA (European Renal Association COVID-19 Database) and the ERA-EDTA Registry reported a death rate after 28 days of follow-up of 25% and 20% respectively [24,25].…”

mentioning

confidence: 99%

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Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Aoun

Khalil

Mahfoud³

et al. 2020

Preprint

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BackgroundHemodialysis patients with COVID-19 have been reported to be at higher risk for death than the general population. Several prognostic factors have been identified in the studies from Asian, European or American countries. This is the first national Lebanese study assessing the factors associated with SARS-CoV-2 mortality in hemodialysis patients.MethodsThis is a cross-sectional study that included all chronic hemodialysis patients in Lebanon who were tested positive for SARS-CoV-2 from 31st March to 1st November 2020. Data on demographics, comorbidities, admission to hospital and outcome were collected retrospectively from the patients' medical records. A binary logistic regression analysis was performed to assess risk factors for mortality.ResultsA total of 231 patients were included. Mean age was 61.46 ± 13.99 years with a sex ratio of 128 males to 103 females. Around half of the patients were diabetics, 79.2% presented with fever. A total of 115 patients were admitted to the hospital, 59% of them within the first day of diagnosis. Hypoxia was the major reason for hospitalization. Death rate was 23.8% after a median duration of 6 (IQR, 2 to 10) days. Adjusted regression analysis showed a higher risk for death among older patients (odds ratio=1.038; 95% confidence interval: 1.013, 1.065), patients with heart failure (odds ratio=4.42; 95% confidence interval: 2.06, 9.49), coronary artery disease (odds ratio=3.27; 95% confidence interval: 1.69, 6.30), multimorbidities (odds ratio=1.593; 95% confidence interval: 1.247, 2.036), fever (odds ratio=6.66; 95% confidence interval: 1.94, 27.81), CRP above 100 mg/L (odds ratio=4.76; 95% confidence interval: 1.48, 15.30), and pneumonia (odds ratio=19.18; 95% confidence interval: 6.47, 56.83).ConclusionsThis national study identified older age, coronary artery disease, heart failure, multimorbidities, fever and pneumonia as risk factors for death in patients with COVID-19 on chronic hemodialysis. The death rate was comparable to other countries and estimated at 23.8%.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Aoun

Khalil

Mahfoud³

et al. 2020

Preprint

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“…We have summarized previous studies reporting mortality rate and its predictors reporting in more than 100 ESRD patients (Table 2) 9,12,[17][18][19][20][21][22][23][24][25][26][27][28][29] . The mortality rate was high between 20-32% (mean 25.4%) in a total of 8,370 patients.…”

Section: Predictors Of Mortality In Esrd Patients With Covid-19mentioning

confidence: 99%

Risks and Benefits of Kidney Transplantation during the COVID-19 Pandemic: Transplant or Not Transplant?

et al. 2021

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COVID-19 disease has significantly affected the transplant community by leading to decreased transplant activity and increased waiting list time. As expected, COVID-19 causes substantial mortality in both end-stage renal disease and kidney transplant populations. This is due to underlying chronic kidney disease and a high prevalence of comorbid conditions such as diabetes mellitus, hypertension, and cardiovascular disease in this group. Transplant programs have faced the difficult decision of weighing the risks and benefits of transplantation during the pandemic. On one hand there is a risk of COVID-19 exposure leading to infection while patients are on maximum immunosuppression. Alternatively, there are risks of delaying transplantation, which will increase waitlist-time and may lead to waitlist-associated morbidity and mortality. Cautious and thoughtful selection of both the recipient's and donor's post-transplant management is required during the pandemic to mitigate the risk of morbidity and mortality associated with COVID-19. In this review article we aimed to discuss previous publications related to clinical outcomes of COVID-19 disease in kidney transplant recipients, end-stage renal disease patients on dialysis or on the transplant waiting-list and precautions transplant centers should take in decision making for recipient and donor selection and immunosuppressive management during the pandemic. Nevertheless, transplantation in this milieu does seem to be the correct decision with a careful patient and donor selection with safeguard protocols for infection prevention. Each center should do risk assessment based on their patient's age and medical comorbidities, waitlist time, degree of sensitization, cold ischemia time, status of vaccination, and severity of pandemic in their region.

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“…A la fragilidad impuesta por la ERC avanzada se suma la necesidad de mayor asistencia y permanencia de este grupo en centros de salud (consultas ambulatorias, centros de hemodiálisis, controles en diálisis peritoneal y policlínica de trasplante). Durante la "primer ola" de la infección se informó en centros europeos que 5% a 20% de los pacientes que concurren a centros de hemodiálisis se infectarán con SARS-CoV-2 2 . Esta prevalencia fue significativamente más baja en la población en diálisis peritoneal y trasplante renal, dado que son tratamientos instituidos de modo predominante en el domicilio 3 .…”

Section: Introductionunclassified

Recomendaciones sobre la vacunación contra SAR S-CoV-2/COVID-19 en pacientes con enfermedad renal crónica y trasplante renal

Silvariño¹,

Ferreiro²,

Seija³

et al. 2024

NEFRO

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Incidence, Characteristics, and Outcome of COVID-19 in Adults on Kidney Replacement Therapy: A Regionwide Registry Study

Cited by 125 publications

References 36 publications

Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Risks and Benefits of Kidney Transplantation during the COVID-19 Pandemic: Transplant or Not Transplant?

Recomendaciones sobre la vacunación contra SAR S-CoV-2/COVID-19 en pacientes con enfermedad renal crónica y trasplante renal

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