Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Aoun, Mabel; Khalil, Rabab; Mahfoud, Walid; Fatfat, Haytham; Khalil, Line Bou; Alameddine, Rashad; Afiouni, N; Ibrahim, Issam; Hassan, Mohamad Ghozali; Zarzour, Haytham; Jebai, Ali; Khalil, Nina Mourad; Tawil, Luay; Mechref, Zeina; Imad, Zuhair El; Chamma, Fadia; Khalil, Ayman; Zeidan, Sandy; Ghoul, Balsam El; Dahdah, Georges; Mouawad, Sarah; Azar, Hiba; Chahine, Kamal Abou; Kallab, Siba; Moawad, Bashir; Fawaz, Ahmad; Homsi, Joseph; Tabaja, Carmen; Delbany, Maya; Kallab, Rami; Hoballah, Hassan; Haykal, W.J.; Fares, Najat; Rahal, Walid; Mroueh, Wael; Youssef, Mohamad; Rizkallah, Jamale; Sebaaly, Ziad; Dfouni, Antoine; Ghosn, Norma; Nawfal, Nagi; Jaoude, Walid Abou; Maroun, T; Bassil, Nabil; Beaini, Chadia; Haddad, Boutros; Moubarak, Elie; Rabah, Houssam; Attieh, Amer; Finianos, Serge; Chelala, Dania

doi:10.21203/rs.3.rs-125343/v1

Cited by 4 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The selection process is illustrated in Figure 1. The 22 included studies 16–37 were from 17 countries, with a total of 13,191 patients. Meta-analysis of epidemiological, clinical, and radiological data from COVID-19 patients undergoing MHD are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis

Guan²,

Zhou

et al. 2022

Science Progress

View full text Add to dashboard Cite

Introduction: The present study systematically reviewed the clinical features and risk factors in patients undergoing maintenance hemodialysis (MHD) who also acquired coronavirus disease 2019 (COVID-19). More specifically, clinical manifestations, prognosis, and risk factors for death among this population were explored. Method: A literature search using the PubMed, Web of Science, and Embase databases, for articles involving patients with laboratory-confirmed COVID-19 and undergoing MHD published between January 1, 2020, and March 13, 2022, was performed. Random-effects meta-analyses were performed to calculate the weighted mean prevalence and corresponding 95% confidence interval (CI) or weighted means and 95% CI. Heterogeneity among studies was assessed using I2 statistics. Results: Twenty-two studies including 13,191 patients with COVID-19 undergoing MHD were selected. The most common symptoms included fever (53% [95% CI 41%–65%]) and cough (54% [95% CI 48%-60%]); however, 17% (95% CI 11%–22%) of the cases were asymptomatic. In subgroup analysis, the proportion of male patients (65% [95% CI 58%–71%]), and patients with coronary artery disease (30% [95% CI 17%–44%) and chronic obstructive pulmonary disease (9% [95% CI 4%–15%]) was greater in the non-survivor group compared with the survivor group. Furthermore, patients undergoing MHD, who were also positive for COVID-19, exhibited a high mortality rate (24% [95% CI 19%–28%]). Conclusions: MHD patients with COVID-19 may initially present as asymptomatic or with mild symptoms; nevertheless, in this study, these patients exhibited a higher risk for death compared with COVID-19 patients not undergoing MHD. Moreover, male sex and underlying cardiovascular and respiratory diseases increased the mortality risk.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies 16–17,21–23,25,27–33,35 reported data regarding treatment(s). Almost all patients underwent symptomatic treatment.…”

Section: Resultsmentioning

confidence: 99%

Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis

Guan²,

Zhou

et al. 2022

Science Progress

View full text Add to dashboard Cite

show abstract

“…Trata-se de um segmento da população com elevada vulnerabilidade, 4 não passível de confinamento restrito, devido à necessidade de receber tratamento regular pelo menos três vezes por semana. Existe, por isso, a necessidade de deslocação em transporte maioritariamente partilhado o que, apesar do esforço realizado pelas autoridades de saúde e por todos os operadores envolvidos em garantir as condições de segurança ideais, representa um risco acrescido.…”

Section: Introductionunclassified

Vacinação Contra a COVID-19 numa Rede de Clínicas de Hemodiálise em Portugal: Uma Experiência Promissora

Matos¹,

Peralta²,

Felix³

et al. 2022

Acta Med Port

View full text Add to dashboard Cite

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) seriously affected Portugal, particularly in the elderly population with a high number of comorbidities, including patients with chronic kidney disease in stage 5 (CKD-5D) undergoing a regular dialysis program. The aims of this study were to identify the impact of vaccination on the incidence of new daily cases and mortality in the CKD-5D population.Material and Methods: Prospective, observational study, involving patients with CKD-5D from 38 NephroCare clinics, Portugal. Daily SARS-CoV-2 infections and mortality among these patients was compared with the incidence in the general population. Three periods were analysed: before vaccination, during the vaccination process, and a third period after complete vaccination with the Pfizer-BioNTech’ Comirnaty® vaccine. The primary outcome was infection by the SARS-CoV-2 virus and the secondary outcome was death associated with the infection.Results: A total of 4617 patients (average of 69.37 years of age) were analysed. During the first period, there was a significantly higher COVID-19 incidence of 14.9% in patients with CKD-5D compared with the general population (7.9%; p < 0.001). During the fifteen days after the complete vaccination, results reverted to a significant decrease in COVID-19 cases was observed (p < 0.001). The mortality rate among CKD-5D was significantly higher than in the general population (p < 0.001).Discussion: A high incidence rate of infection was observed in CKD-5D patients, probably due to several factors such as advanced age, number of comorbidities, inability to remain in confinement, among others. After vaccination there was a significant reduction of new cases.Conclusion: Vaccination significantly reduced SARS-CoV-2 infection in patients with CKD-5D.

show abstract

“…■ Alrededor del 40% de los pacientes pasaron por una enfermedad leve controlada desde su domicilio, según dos artículos revisados Por lo tanto, la presentación grave de la enfermedad se presentó al menos en la mitad de la población de estudio. La principal causa de hospitalización y enfermedad grave fue la hipoxia 17 . Además, se relacionó la hospitalización con pacientes de mayor edad, fumadores, con arritmias o con dependencia 25 .…”

Section: Se Analizaron 8 Artículos Para Determinar El Curso Clínico D...unclassified

“…■ Edad avanzada. La edad mayor a 65 años es un potente predictor de mortalidad 17,23 , aunque la mayor tasa de fallecimientos por COVID-19 en la población en diálisis se registra en el grupo de edad de entre 75-80 años 22,25 .…”

Section: Los Factores De Riesgo De Mortalidad Más Mencionados En Los ...unclassified

COVID-19 en el paciente en diálisis. Una revisión sistemática

2021

View full text Add to dashboard Cite

Introducción: La pandemia por COVID-19 acaecida en 2019 afectó con mayor gravedad a la población de mayor edad y con enfermedades subyacentes, siendo estos factores de riesgo de mortalidad. Estas características son propias del paciente renal en diálisis, por lo que es importante conocer cuál fue el impacto del COVID-19 en este grupo poblacional.Objetivo: El objetivo principal fue conocer y sintetizar la evidencia científica existente sobre las características clínicas de la enfermedad COVID-19 en el paciente con enfermedad renal crónica en diálisis.Metodología: Se realizó una revisión sistemática basada en la declaración PRISMA, en la que se analizaron 23 artículos procedentes de las bases de datos PubMed y Scopus. Se incluyeron artículos originales en inglés y español que excluyeran la población pediátrica.Resultados: Se incluyeron 23 artículos de diseño observacional. Principalmente los resultados se centraron en incidencia, características clínicas, como sintomatología o evolución, mortalidad y medidas preventivas en las unidades de diálisis.Conclusiones: La incidencia de la COVID-19 fue mayor en unidades de diálisis que en los pacientes que recibían diálisis domiciliaria. La sintomatología más leve fue la común a la población general. En los casos más graves, cerca del 50% de los pacientes necesitaron hospitalización y/o ingreso en una Unidad de Cuidados Intensivos. La mortalidad fue bastante elevada y se relacionó con la edad avanzada, comorbilidad, sexo masculino o fragilidad clínica. Además, en las unidades de diálisis se implementaron medidas de prevención de la enfermedad, al ser espacios físicos cerrados donde se concentra un gran número de pacientes.

show abstract

Age and Multimorbidities as Poor Prognostic Factors for COVID-19 in Hemodialysis: a Lebanese National Study

Cited by 4 publications

References 27 publications

Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis

Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis

Vacinação Contra a COVID-19 numa Rede de Clínicas de Hemodiálise em Portugal: Uma Experiência Promissora

COVID-19 en el paciente en diálisis. Una revisión sistemática

Contact Info

Product

Resources

About