Incidence and Survival Patterns of Sinonasal Undifferentiated Carcinoma in the United States

Chambers, Kyle J.; Lehmann, Ashton E.; Remenschneider, Aaron K.; Dedmon, Matthew M.; Yarlagadda, Bharat B.; Gray, Stacey T.; Lin, Derrrick

doi:10.1055/s-0034-1370472

Cited by 38 publications

(74 citation statements)

References 9 publications

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“…SNUCs are uncommon head and neck tumors with an estimated incidence of 0.02 per 100 000 persons . Due to the rarity of this malignancy, only a few small retrospective series have been reported.…”

Section: Discussionmentioning

confidence: 99%

Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience

et al. 2017

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“…Thus, it is a tumor of exclusion, comprising 3-5% of all sinonasal tract carcinomas. [45][46][47] Clinical. Affecting a wide age range, the tumor is most common in 50-60 year olds, with men affected much more frequently than women.…”

Section: Mesenchymal Chondrosarcomamentioning

confidence: 99%

“…Affecting a wide age range, the tumor is most common in 50-60 year olds, with men affected much more frequently than women. [45][46][47][48][49] Often with a rapid clinical presentation, obstructive symptoms are related to tumor presentation as large, midline widely destructive masses, starting in the nasal cavity, but rapidly expanding into adjacent sites (60% have orbit or skull base extension). [48][49][50] Histopathology.…”

Section: Mesenchymal Chondrosarcomamentioning

confidence: 99%

“…The overall prognosis is poor, but with aggressive multimodality therapy, including primary surgical resection, 5-year survival rates or 35-63% are achieved, but with a median overall survival of about 2 years. [46][47][48][49]53,60,[62][63][64][65][66] Local recurrence is common, but nodal metastases are relatively uncommon, although distant metastases are frequent.…”

Section: Mesenchymal Chondrosarcomamentioning

confidence: 99%

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Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Thompson

2017

Modern Pathology

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One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached. Discrimination between neoplasms is critical as there are significant differences in therapy and overall outcome. It is important to have a well developed differential diagnosis for this category of tumors, where each of the diagnoses is considered, evaluated, and either confirmed or excluded from further consideration. In an undifferentiated tumor, showing a small round blue cell morphology, using the mnemonic 'MR SLEEP' helps to highlight tumors to consider: melanoma, mesenchymal chondrosarcoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, squamous cell carcinoma (including NUT carcinoma), small cell osteosarcoma, lymphoma, esthesioneuroblastoma (olfactory neuroblastoma), Ewing sarcoma/primitive neuroectodermal tumor, pituitary adenoma, and plasmacytoma. A panel of pertinent immunohistochemistry studies, histochemistries and/or molecular tests should aid in reaching a diagnosis, especially when taking the pattern and intensity of reactions into consideration.

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“…Median survival from 1973 to 1986 and 1986 to 2010 was 14.5 and 23.5 months, respectively; thereby confirming the survival benefit of surgery and radiation therapy and identifying a trend toward improvement in survival in recent decades. 16 Despite advances in anterior skull base surgery and chemoradiation therapy, the cure-rate for SNUC remains dismally low. Recurrence rate is very high and many patients die of disease within months of diagnosis.…”

mentioning

confidence: 99%

Sinonasal Undifferentiated Carcinoma: A Case Report and Review of Literature

Chitguppi¹

2015

An International Journal Clinical Rhinology

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Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor of the nasal cavity and paranasal sinuses. It can be differentiated from other neoplasms by correlating clinical, light microscopic, immunohistochemical and ultrastructural characteristics. Due to the small number of reported cases, the ideal treatment regimen has not been systematically evaluated. The treatment of SNUC includes aggressive multimodality therapy, including surgical resection and adjuvant treatment (i.e. radiotherapy, chemotherapy) because of high rate of both loco-regional recurrence and distant metastasis.

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Incidence and Survival Patterns of Sinonasal Undifferentiated Carcinoma in the United States

Cited by 38 publications

References 9 publications

Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience

Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Sinonasal Undifferentiated Carcinoma: A Case Report and Review of Literature

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