Sinonasal Undifferentiated Carcinoma: A Case Report and Review of Literature

Chitguppi, Chandala

doi:10.5005/jp-journals-10013-1234

Cited by 2 publications

(1 citation statement)

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“…Radical craniofacial resection may be required with maxillectomy and orbital exenteration. Craniofacial resection with a tumorfree margin is positively related to tumor-free survival status [17]. However, SNUC may not be completely treated by surgery or radiation therapy and it has a high rate of both local-regional recurrence and distant metastases [3].…”

Section: Discussionmentioning

confidence: 99%

Compressive Optic Neuropathy Secondary to Sinonasal Undifferentiated Carcinoma in a Young Male

Hassan

Hitam

Masnon

et al. 2021

Cureus

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Sinonasal undifferentiated carcinoma (SNUC) is an extremely aggressive malignancy. Extension to the orbit and adjacent structures is common, but isolated visual loss as a presenting symptom is rare. We report a rare case of SNUC with bilateral visual loss as the initial manifestation. A 34-year-old gentleman was presented with acute onset loss of vision in both eyes for one week. It was followed by recurrent headaches and epistaxis. Visual acuity in the right eye was 2/60 and 3/60 in the left eye. Funduscopy showed a bilateral swollen disc. Neuroimaging revealed a large mass in the ethmoidal sinus extended laterally causing compression to recti muscles and the optic nerves. The histopathological examination of nasal tissue biopsy showed features of SNUC with bone and perineural invasion. A diagnosis of SNUC with bilateral compressive optic neuropathy was established. The patient underwent tumor debulking and base of skull reconstruction by the neurosurgical team. This was then followed by chemotherapy and radiotherapy. The patient's right eye visual acuity initially improved to 6/9. However, his both eye vision developed into no light perception during treatment. In conclusion, SNUC is a highly aggressive tumor that may present with acute blindness. Early treatment may save a life, but the visual prognosis is guarded due to extensive optic nerve damage caused by tumor compression.

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Section: Discussionmentioning

confidence: 99%