Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults

Annertz, Karin; Anderson, Harald; Biörklund, Anders; Möller, Torgil; Kantola, Saara; Mork, Jon; Olsen, Jørgen H.; Wennerberg, Johan

doi:10.1002/ijc.10577

Cited by 215 publications

(156 citation statements)

References 30 publications

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“…In the present study, as shown in Table 1, the male/female ratio was approximately 1:1; females predominated among the patients with cancer of the mobile tongue, whereas hypopharyngeal cancer is more common among males. This is in accordance with other recent reports (22). Interestingly, the majority (68%) of the females who reported smoking habits were nonsmokers, with the highest figure among tongue cancer patients, which is the fastest increasing group in Finland (5).…”

Section: Discussionsupporting

confidence: 43%

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

et al. 2003

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Section: Discussionsupporting

confidence: 43%

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

et al. 2003

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“…The incidence of OSCC in patients younger than 45 years has been reported to ranging from 0.4%-6.7% of all cases (Llewellyn et al, 2001). However, epidemiologic studies demonstrate an increasing incidence of OSCC young patients worldwide especially among young females (Myers et al, 2000;Annertz et al, 2002;Warnakulasuriya, 2009;Patel et al, 2011).…”

Section: Introductionsupporting

confidence: 46%

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

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“…[2][3][4] As already suggested in 1983, these OPSCC are characterized by human papilloma virus (HPV) infection. 5 Viral DNA of high risk HPV 16 can be detected in nuclei of tonsillar cancer cells, 6 and is responsible for the vast majority of HPV positive tumors.…”

mentioning

confidence: 43%

Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?

Fischer

Zlobec

Green

et al. 2009

Intl Journal of Cancer

154

128

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The incidence of human papilloma virus (HPV) induced oropharyngeal squamous cell carcinoma (OPSCC) increases in the western countries. These OPSCC show distinct molecular characteristics and are characterized by an overexpression of p16, considered a surrogate marker for HPV infection. When compared to patients with p16 negative OPSCC, patients with HPV induced p16 positive OPSCC show a significantly better prognosis, which is reported to be caused by increased radiosensitivity. The objective of the present study was to analyze the impact of p16 expression status on the prognosis of OPSCC treated by either radiotherapy (RT) or primary surgery. Results are based upon a tissue microarray (TMA) of 365 head neck squamous cell carcinomas (HNSCC) including 85 OPSCC with clinico-pathological and follow-up data. p16 positivity correlated significantly with oropharyngeal tumor localization (p < 0.001). Patients with p16 positive OPSCC exhibited a significantly better overall survival than those with p16 negative tumors (p 5 0.007). In a multivariate analysis, survival benefit of patients with p16 positive OPSCC was independent of clinico-pathological parameters such as cT and cN classification and treatment modality. The improved prognosis of p16 positive OPSCC is found after RT as well as after surgery.Although incidence of head and neck squamous cell carcinoma (HNSCC) in general has decreased progressively during the last two decades, 1 an increased incidence of oral and oropharyngeal squamous cell carcinoma (OPSCC) was reported in the United States as well as in Europe. [2][3][4] As already suggested in 1983, these OPSCC are characterized by human papilloma virus (HPV) infection. 5 Viral DNA of high risk HPV 16 can be detected in nuclei of tonsillar cancer cells, 6 and is responsible for the vast majority of HPV positive tumors. 7 These tumors arise mainly in the lingual and palatal tonsils and are characterized as being a type of HNSCC with different distinct epidemiological, molecular, and clinical characteristics. 8 The main risk factor for these HPV positive OPSCC is sexual behavior with a high number of vaginal or oral sex partners. 8,9 HPV-induced OPSCC show distinct molecular characteristics suggesting a different pathway in carcinogenesis compared to HPV negative HNSCC. 10 One particular molecular difference among others concerns p16 expression. p16 functions as a cell-cycle checkpoint regulator, a tumor suppressor gene located on chromosome 9p21.In HPV negative HNSCC p16 is frequently inactivated by deletions, mutations or promoter methylation. 11 In HPV positive OPSCC, overexpressed viral oncoprotein E7 degrades pRb, 12 which otherwise inhibits p16 transcription. 13 The resulting nuclear and cytoplasmic p16 overexpression correlates precisely to HPV positivity and is suggested to be specific for HPV positive OPSCC. 14,15 As p16 overexpression is very rarely seen in HPV negative HNSCC it is considered a surrogate marker for HPV positive OPSCC. Direct diagnosis of HPV in HNSCC is only reliably possible by in s...

show abstract

Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults

Cited by 215 publications

References 30 publications

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

Treatment of Squamous Cell Carcinoma of the Oral Cavity, Oropharynx and Hypopharynx An Analysis of 174 Patients in South Western Finland

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?

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