Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review

Saadati, Hossein Mozafar; Okhovat, Batool; Khodamoradi, Farzad

doi:10.1007/s12029-020-00574-x

Cited by 9 publications

(10 citation statements)

References 23 publications

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“…Due to much sedentary work and less fiber intake instead of more daily activities like walking in rural populations, obesity and a high body mass index (BMI) 24 was associated with the higher risk of CRC. The World Health Organization also pointed out that high-fat diet and excessive intake of animal protein, especially red meat, 25 were risk factors for colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Sun¹,

Liu²,

Huang³

et al. 2021

IJGM

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Purpose This study aimed to analyze incidence and mortality trends and risk factors of colorectal cancer (CRC) in China during 2005–2015. Materials and Methods Patient cases were extracted from the Chinese Cancer Registry Annual Report. Joinpoint regression and Poisson regression were applied to analyze incidence and mortality trends and risk factors of CRC. Age-period-cohort model was used to evaluate the age, period and cohort effects on CRC. Results The standardized incidence and mortality rate of CRC in China showed a decreasing trend during 2005–2015. The incidence in men (APC=−1.22%, P<0.05) decreased from 2005 to 2015 and decreased in women (APC =−3.55%, P<0.05) from 2005 to 2013, then increased during 2013–2015 (APC =18.77%, P<0.05). The incidence and mortality in urban areas were higher than those in rural (The incidence in urban: APC =−0.97%, P<0.05; rural: APC =1.94%, P<0.05; the mortality in urban: APC =−0.67%, P<0.05; rural: APC =0.29%). For age-specific rates, the incidence begins to increase significantly at 40–45 age group and reached a peak at 75; the mortality increased significantly at 45–50. The age effect increased with age in general. The 1920 birth cohort had the highest risk of colorectal cancer incidence and death. Poisson regression showed region, gender and age were independent risk factors of CRC. Conclusion The age-adjusted standardized incidence rate (ASIR) and age-adjusted standardized mortality rate (ASMR) of CRC in China during 2005–2015 were decreasing. A great concern on men, rural areas and people aged over 75 should be aroused to prevent colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Sun¹,

Liu²,

Huang³

et al. 2021

IJGM

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“…Wong et al (20) referred to genetic, family history, ethnicity, and age, as well as lifestyle factors such as diet, physical activity, alcohol consumption, smoking, weight, and chronic diseases as CRC risk factors among Asian populations (20). Based on the results of a systematic review, high consumption of red meat and convenience foods, low consumption of fruits and vegetables, as well as diabetes, obesity, positive CRC family history were among the most important CRC risk factors (10). More precise planning is required to control CRC in the future due to the difference in CRC incidence and risk factors in the various areas of Iran (10).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the results of a systematic review, high consumption of red meat and convenience foods, low consumption of fruits and vegetables, as well as diabetes, obesity, positive CRC family history were among the most important CRC risk factors (10). More precise planning is required to control CRC in the future due to the difference in CRC incidence and risk factors in the various areas of Iran (10).…”

Section: Discussionmentioning

confidence: 99%

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Participation Rate, Risk Factors, and Incidence of Colorectal Cancer in the Screening Program Among the Population Covered by the Health Centers in Arak, Iran

et al. 2021

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Background: Colorectal cancer (CRC) is among the most common and preventable cancers, the incidence and risk factors of which are different in various populations. Objectives: The present study aims at assessing incidence rate, risk factors, and symptoms of CRC among the populations aged 50 to 70 years old covered by the health centers in Arak, as well as evaluating participation rate in the CRC screening program. Methods: The present cross-sectional study was conducted from 2016 to 2019 among all of the individuals aged 50 to 70 years old, who were referred to rural, urban, and suburban health centers in Arak for CRC screening, and their data were recorded in the Sib system. The participation rate, risk factors (family and individual history of CRC, colorectal adenoma, and inflammatory bowel disease), symptoms (lower gastrointestinal bleeding, constipation with or without diarrhea, and weight loss), and crude incidence rate of CRC were calculated in the age range. Results: The mean (SD) age of the CRC was 59.72 (5.56) years. In addition, the individuals’ participation rate in the program was about 44.2%, which was more among women (55.5%) and villagers (93.7%). Most subjects complained of constipation in the last month and CRC family history. The CRC crude incidence rates were 35.93 (95% CI: 25.55 - 50.54), 40.96 (95% CI: 29.81 - 56.29), 43.76 (95% CI: 32.22 - 59.43), and 52.84 (95% CI: 40.05 - 69.71) per 100000 individuals during 2016, 2017, 2018, and 2019, respectively. Conclusions: The participation rate in the CRC screening program was low, and the trend of the cancer crude incidence rate increased among the populations aged 50 to 70 years. Finally, informing about the recognition of the risk factors and symptoms of cancer, as well as the timely referral for screening was considered essential.

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“…Most recent studies implicate a diet high in fat, especially saturated fatty acids, red meat, and low in fiber, vitamin D, or dairy products. 46 The risk of development of CRC due to a high-fat diet is thought to be due to exposure of gut mucosa to carcinogenic heterocyclic amines, polycyclic aromatic hydrocarbons, 47 and nitroso compounds. 48,49 Unlike the current study that did not find a strong relationship between diet and CRC, two previous studies demonstrated a significant relationship between plasma phospholipids and CRC.…”

Section: Dovepressmentioning

confidence: 99%

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

Wekha

Ssewante

Iradukunda

et al. 2021

CMAR

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Introduction:Colorectal cancer (CRC) is the most common type of gastrointestinal malignancies and the third leading cause of cancer-related deaths for both sexes worldwide. Although the burden of CRC is highest in developed countries, reports are indicating a rise in the incidence of early-onset CRC in developing countries. In this study, we aimed to determine the prevalence of CRC among patients hospitalized with lower gastrointestinal complaints at a tertiary health facility in Uganda. Methods: We conducted a 10-year retrospective chart review of patients admitted to Mulago National Referral Hospital in Kampala, Uganda, between 1st January 2010 and 31st December 2020. We reviewed all charts of patients admitted to the lower gastrointestinal tract (GIT) ward. Charts with grossly missing data, pediatric patients, and those from other non-lower GIT specialties were excluded. Results: Data of 1476 unique eligible patients were analyzed. Of these,138 had a diagnosis of CRC (prevalence: 9.3%, 95% confidence interval (95% CI): 6.5-11.7%). Among patients with CRC, the female:male ratio was 1:1. The most common site for CRC was the rectum (59.8%, n= 79). For the 138 participants with CRC, 44 had staging data with 72.8% (n=32) having advanced disease, that is, stage 3 or 4. Factors independently associated with CRC were age ≥50 years (adjusted odds ratio (aOR): 4.3, 95% CI: 2.6-7.1, p < 0.001), female sex (aOR: 1.8, 95% CI: 1.2 −2.8, p = 0.005), being widowed (aOR: 2.5, 95% CI: 1.3-5.0, p = 0.006), and presence of any risk factor for CRC (aOR: 5.3, 95% CI: 2.9-9.9, p < 0.001). Conclusion: CRC is relatively common among patients hospitalized with lower GIT complaints, particularly among women and those with known risk factors for CRC. Awareness creation and screening programs should be instituted to allow early diagnosis of CRC in our setting.

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Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review

Cited by 9 publications

References 23 publications

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Participation Rate, Risk Factors, and Incidence of Colorectal Cancer in the Screening Program Among the Population Covered by the Health Centers in Arak, Iran

Colorectal Cancer in Uganda: A 10-Year, Facility-Based, Retrospective Study

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