Incidence and risk factors of food allergy after umbilical cord blood transplantation in children

Hernández-Ojeda, Alfonso; Rojas, Nicolás; Barriga, Francisco; Wietstruck, María Angélica; Morales, Pamela S.; Borzutzky, Arturo

doi:10.1016/j.jaip.2017.04.034

Cited by 5 publications

(3 citation statements)

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“…There were three pediatric cases with no report of either value, and one report with the total serum IgE value and the term elevated peripheral eosinophil counts. These reports were therefore not included for analysis 3,6…”

Section: Resultsmentioning

confidence: 99%

“…One frequently cited mechanism involves gut permeability and induction of Th2 inflammatory responses, as a result of the use of tacrolimus. The use of tacrolimus as a risk factor has been identified and among 10 of 12 patients studied, the drug was used prior to development of food allergy 3. In the same study, all cases were also diagnosed with GVHD.…”

Section: Discussionmentioning

confidence: 99%

“…Another literature study described an association between graft-versus-host disease (GVHD) and food allergies. Those patients who had received tacrolimus were more likely to develop food allergies (16.1% vs 3.2%, p =0.015) 3. There is a focus on tacrolimus because this is a commonly used transplant immunosuppressive medication, and thus one possible such effect may be considered among this specific cohort.…”

Section: Introductionmentioning

confidence: 99%

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<p>Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies</p>

Dosanjh¹,

Lew²

2019

JAA

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The use of immunosuppressive treatments and their related gastrointestinal adverse effects have been implicated in the development of food allergic responses following transplantation. There is limited information on the pathogenesis of the food allergic immune response among umbilical cord transplantation recipients. This study was conducted to identify a cohort of food allergic umbilical cord recipients in the literature. The literature was searched to systematically identify this cohort. Criteria for inclusion included umbilical cord transplantation, food allergic response, and reported laboratory data. Analysis of the laboratory data using the Pearson method revealed that there was a moderate negative correlation with a coefficient of r =−0.7016 and r 2 =−0.49 between peripheral eosinophilia and serum immunoglobulin E (IgE) levels. Future studies on a larger population are needed, but this study may help to elucidate possible cellular mechanisms involved in this response.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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