Incidence and Risk Factors for Developing Glaucoma Among Patients with Uveitis in a University-based Tertiary Referral Center in Riyadh, Saudi Arabia

Rubaie, Khalid Al; Dhahri, Huda Al; Fawaz, Abdullah Al; Hemachandran, Suhail; Mousa, Ahmed; Mohamed, Ashry Gad; Al-Obeidan, Saleh A.; El‐Asrar, Ahmed M. Abu

doi:10.3109/09273948.2015.1047036

Cited by 16 publications

(8 citation statements)

References 27 publications

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“…This is in line with previous report on the anatomic distribution of uveitis in Saudi Arabia. 9,24,25 Nevertheless, some studies reported no difference in incidence of uveitic glaucoma in relation to anatomic classi cation and etiology while others found anterior uveitis as the main cause of uveitic glaucoma. 2,8,[26][27][28][29] The presence of anterior segment in ammation contributes to the development of glaucoma in anterior uveitis and panuveitis by directly affecting the trabecular meshwork, while aqueous out ow pathway is less in uenced by posterior segment in ammation.…”

Section: Discussionmentioning

confidence: 99%

“…2,8,[26][27][28][29] The presence of anterior segment in ammation contributes to the development of glaucoma in anterior uveitis and panuveitis by directly affecting the trabecular meshwork, while aqueous out ow pathway is less in uenced by posterior segment in ammation. Alrubaie et al 9 reported that glaucoma surgery was most frequent in anterior uveitis and panuveitis in 1220 eyes with uveitis in Saudi Arabia. In the current study, the most common etiologic diagnosis was VKH and idiopathic uveitis, while most patients were females and males in the granulomatous and non-granulomatous uveitis groups, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Granulomatous uveitis carries a greater risk of developing uveitic glaucoma 8 , and there is need for glaucoma surgery compared with non-granulomatous uveitis. 9 Several studies reported a favorable outcome of Mitomycin C (MMC) enhanced trabeculectomy in uveitic glaucoma, but few have looked at the outcome in glaucoma associated with major uveitis entities such as granulomatous and non-granulomatous uveitis. [10][11][12][13][14][15] Therefore, the aim of our study was to evaluate the outcomes of MMC enhanced trabeculectomy as a rst procedure in patients with glaucoma associated with granulomatous and non-granulomatous uveitis.…”

Section: Introductionmentioning

confidence: 99%

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Long-term outcomes of initial trabeculectomy in glaucoma associated with granulomatous and non-granulomatous uveitis

et al. 2021

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To evaluate the outcomes of initial trabeculectomy in granulomatous and non-granulomatous uveitis. MethodsRetrospective comparative study of 68 eyes that underwent an initial trabeculectomy. ResultsThe mean follow-up was 74.18 and 74.86 months in both groups (p = 0.95). The intraocular pressure decreased from 40.03 mmHg (± 7.2) and 36.48 mmHg (± 11.3) to 14.00 mmHg (± 6.2) and 13.48 mmHg (± 5.7), the number of medications decreased from 3.73 (± 0.7) and 3.58 (± 0.9) to 1.00 (± 1.4) and 1.13 (± 1.4) on the last follow-up (p < 0.01) in the granulomatous and non-granulomatous groups, respectively.More eyes in the granulomatous uveitis group developed delayed postoperative complications like cataract, transient hypotony and glaucoma progression. Success rates were 64.9 and 71.0%, while failure rates were 35.1 and 29.0% in both groups (p = 0.84). ConclusionsTrabeculectomy seems to have comparable IOP control and survival in granulomatous and nongranulomatous uveitis. Nevertheless, more eyes in the granulomatous uveitis group developed late onset complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term outcomes of initial trabeculectomy in glaucoma associated with granulomatous and non-granulomatous uveitis

et al. 2021

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“…5 The incidence of the major types of uveitis such as sarcoidosis, VKH disease, and infectious uveitis was lower in our study compared with previously published studies in Germany, 16 Italy, 5 Japan, 8,20 and Saudi Arabia. 21 The pattern of uveitis in various geographic regions is influenced by various combinations of geographic, environmental, and genetic factors. Sarcoidosis is more common in people of Northern European descent rather than Mediterranean descent, and Vogt-Koyanagi-Harada disease occurs more commonly in patients with HLA associations seen in Asian and Middle Eastern populations.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of uveitic glaucoma in Turkish patients

Tekeli

Elgin

Takmaz

et al. 2020

European Journal of Ophthalmology

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Purpose: To evaluate the prevalence of uveitic glaucoma (UG) in the Turkish population and investigate the primary underlying diseases. Methods: This multicenter, cross-sectional, prospective study included patients who presented to the glaucoma units of 10 tertiary ophthalmology departments in Ankara, Turkey from 15th March to 16th May 2015 and fulfilled the criteria of UG. Patients were inspected for age, sex, medical history, best corrected visual acuity, biomicroscopic findings, intraocular pressure values, and visual field results. Results: During the study period, 4604 eyes of 2541 patients with glaucoma were screened and 145 eyes of 104 patients (4.1%) were identified as having UG. One hundred and thirty-four eyes (92.4%) had open-angle glaucoma and 11 eyes (7.6%) had closed-angle glaucoma. The mean patient age was 47 ± 16 (6–90) years. Idiopathic uveitis (54 eyes), Behçet’s disease (26 eyes), Fuchs heterochromic cyclitis (21 eyes), Herpes Simplex virus infectious uveitis (14 eyes), and ankylosing spondylitis (six eyes) were the leading types of uveitis associated with glaucoma. Acute anterior uveitis was the most common type of uveitis diagnosed in 72 patients (105 eyes), whereas 21 patients (27 eyes) had panuveitis, eight patients (nine eyes) had intermediate uveitis, and three patients (four eyes) had posterior uveitis. The need for surgical intervention was 37.2% among all cases and the most common surgery was trabeculectomy in 45 eyes. Conclusion: UG is a vision-threatening complication commonly seen in patients with uveitis. This study demonstrates the epidemiological features and underlying etiologies of UG in the Turkish population. The most common primary causes of UG were Behçet’s disease and Fuchs heterochromic cyclitis.

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“…When considering eyes that had angle-closure glaucoma, 69.1% had the chronic VKH disease associated with recurring episodes of anterior segment in ammation. The chronic recurrent form is signi cantly associated with secondary glaucoma [6,12,14,16,19,20]. Arevalo et al reported that 58.4% and 20.7% of the eyes that developed glaucoma had the chronic recurrent and acute form of VKH disease, respectively (p ≤ 0.0001) [12].…”

Section: Management Of Secondary Glaucomamentioning

confidence: 99%

Prevalence of Angle Closure Glaucoma in Vogt-Koyanagi-Harada Disease

Alvarez-Guzman

Valdez-García

Ruiz-Lozano

et al. 2021

Preprint

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Background: This study aims to determine the prevalence, clinical characteristics, and mechanisms of secondary glaucoma in Vogt-Koyanagi-Harada (VKH) disease. We performed a retrospective, observational, and longitudinal study in VKH patients seen from 2001 to 2019. Demographic data, disease stage, glaucoma development, visual outcome, and management were analyzed. Results: A total of 305 eyes from 155 VKH patients, including 114 (74.4%) females and 39 (25.6%) males with a mean age of 38.8± 12.8 years, were analyzed. The median follow-up time was 22 months (range 7-60 months). Secondary glaucoma developed in 67 (22.0%) eyes, most of which had chronic recurrent VKH disease at presentation 43 eyes (62.4 %). Angle-closure was the most observed mechanism of glaucoma in 55 (82.1%) eyes, as shown by the development of peripheral anterior synechiae in 58 (86.6%) eyes and posterior synechiae in 51 eyes (76.1%). The combination of pupillary block and posterior synechiae resulted in iris bombé in 17 (25.4%) eyes with glaucoma. Forty-one (61.2%) eyes with glaucoma required either a laser or surgical procedure to control the intraocular pressure. At the last visit, visual acuity was significantly worse in eyes with glaucoma (p<0.001).Conclusions: As evidenced by the development of anterior and posterior synechiae, the angle-closure disease is a significant cause of secondary glaucoma in eyes with VKH. Eyes with glaucoma are more likely to present in the chronic recurrent stage of the disease. Most of the eyes with glaucoma required a surgical procedure to control intraocular pressure.

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Incidence and Risk Factors for Developing Glaucoma Among Patients with Uveitis in a University-based Tertiary Referral Center in Riyadh, Saudi Arabia

Abstract: Incidence of glaucoma differed depending on anatomic and etiologic diagnoses of uveitis. There is a significant association between severity of inflammation at presentation and development of glaucoma.

Cited by 16 publications

References 27 publications

Long-term outcomes of initial trabeculectomy in glaucoma associated with granulomatous and non-granulomatous uveitis

Long-term outcomes of initial trabeculectomy in glaucoma associated with granulomatous and non-granulomatous uveitis

Characteristics of uveitic glaucoma in Turkish patients

Prevalence of Angle Closure Glaucoma in Vogt-Koyanagi-Harada Disease

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