Incidence and prevalence of epilepsy in Denmark

Christensen, Jakob; Vestergaard, Mogens; Pedersen, Marianne Giørtz; Pedersen, Carsten Bøcker; Olsen, Jørn; Sidenius, Per

doi:10.1016/j.eplepsyres.2007.06.012

Cited by 165 publications

(145 citation statements)

References 18 publications

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“…The use of computerized databases has already proven to be relevant in prevalence studies conducted in large populations [19,20] or nationwide [21], in which, however, the clinical classification of epilepsies could not be performed. …”

Section: Discussionmentioning

confidence: 99%

Epilepsy in Sardinia, Insular Italy: A Population-Based Prevalence Study

Cossu

Deriu²,

Casetta³

et al. 2012

Neuroepidemiology

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Background: Sardinia, insular Italy, represents a particular epidemiological setting to investigate polyfactorial diseases, by virtue of its phylogeny and geographic isolation over time and of a well-established network of health operators and information systems. We present the first prevalence study of epilepsy conducted on a large Sardinian population by means of multiple source ascertainment. Methods: Cases were ascertained in the province of Sassari (population of 333,576) for the period between January 1, 2000 and December 31, 2008 based on records from (a) the District Center for Epilepsy, (b) the District Health Information System Unit, and (c) the neurologists practicing within the National Health System. Results: The total crude prevalence of active epilepsy on December 31, 2007 was 6.62 per 1,000 (95% CI 5.3–7.9), 6.51 in men (95% CI 5.4–7.6), and 6.73 in women (95% CI 5.7–7.7). The highest prevalence (8.78 per 1,000) was estimated in the elderly (≥65 years). 50.5% were symptomatic epilepsies. Of these, over 50% were secondary to cerebrovascular disorders in the elderly. Conclusions: The epidemiological behavior of prevalence of active epilepsy in Sardinia appears to be in line with that of other developed countries, despite the role that population-specific genetic and environmental factors exert in modulating the risk for other neurological diseases. The action of (exogenous) factors commonly distributed in western populations, also influencing, at least partially, the epidemiological patterns of epilepsy in Sardinians, should not be ruled out.

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Section: Discussionmentioning

confidence: 99%

Epilepsy in Sardinia, Insular Italy: A Population-Based Prevalence Study

Cossu

Deriu²,

Casetta³

et al. 2012

Neuroepidemiology

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“…1 Low gestational age, birth weight, 2 and Apgar score 3 are associated with an increased risk of epilepsy and febrile seizures. 4 These risk factors have also been associated with an increased risk of attentiondeficit/hyperactivity disorder (ADHD).…”

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confidence: 99%

Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD

et al. 2016

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OBJECTIVES: Epilepsy, febrile seizures, and attention-deficit/hyperactivity disorder (ADHD) are disorders of the central nervous system and share common risk factors. Our goal was to examine the association in a nationwide cohort study with prospective follow-up and adjustment for selected confounders. We hypothesized that epilepsy and febrile seizures were associated with subsequent ADHD. METHODS:A population-based cohort of all children born in Denmark from 1990 through 2007 was followed up until 2012. Incidence rate ratios (IRRs) and 95% confidence intervals (95% CIs) for ADHD were estimated by using Cox regression analysis, comparing children with epilepsy and febrile seizure with those without these disorders, adjusted for socioeconomic and perinatal risk factors, as well as family history of neurologic and psychiatric disorders. RESULTS:A total of 906 379 individuals were followed up for 22 years (∼10 million personyears of observation); 21 079 individuals developed ADHD. Children with epilepsy had a fully adjusted IRR of ADHD of 2.72 (95% CI, 2.53-2.91) compared with children without epilepsy. Similarly, in children with febrile seizure, the fully adjusted IRR of ADHD was 1.28 (95% CI, 1.20-1.35). In individuals with both epilepsy and febrile seizure, the fully adjusted IRR of ADHD was 3.22 (95% CI, 2.72-3.83). CONCLUSIONS:Our findings indicate a strong association between epilepsy in childhood and, to a lesser extent, febrile seizure and subsequent development of ADHD, even after adjusting for socioeconomic and perinatal risk factors, and family history of epilepsy, febrile seizures, or psychiatric disorders. Ms Bertelsen conceptualized and designed the study, conducted the initial analyses, and drafted the initial manuscript; Ms Larsen conducted the initial analyses and critically reviewed the manuscript; Dr Petersen supervised the initial analyses and critically reviewed the manuscript; Dr Christensen conceptualized and designed the study, helped draft the initial manuscript, and critically reviewed the manuscript; Dr Dalsgaard conceptualized and designed the study, helped draft the initial manuscript, and critically reviewed the manuscript; and all authors approved the fi nal manuscript as submitted. WHAT'S KNOWN ON THIS SUBJECT:Several studies have demonstrated an association between seizure disorders and attention-defi cit/hyperactivity disorder in childhood. Genetic and environmental risk factors infl uence this association, but former studies on this subject have been limited by retrospective designs and small sample sizes. WHAT THIS STUDY ADDS:This prospective population-based study found a strong association between childhood epilepsy and febrile seizures and subsequent attention-defi cit/hyperactivity disorder, even after adjusting for perinatal and socioeconomic risk factors, as well as family history of neurologic and psychiatric disorders.by guest on May 9, 2018 http://pediatrics.aappublications.org/ Downloaded from BERTELSEN et alThe population prevalence of epilepsy has been esti...

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“…Epilepsy is one of the most common neurological disorders and occurs with an incidence of 68.8/100,000 person per years [1]. Despite proper medical treatment, on average one third of patient continues to have seizure [2].…”

Section: Introductionmentioning

confidence: 99%