Incidence and Outcomes of Acute Kidney Injury in Critically Ill Patients with Coronavirus Disease 2019

Abdallah, Emad; Helal, Bassam Al; Asad, Reem; Hemida, Mohamed; Nawar, Ehab; Kamal, Mohammad Amjad; Reda, M.; Baharia, Ahmed; Galal, Ahmed; Hassan, Ali; Awaga, Ahmed; Salam, Mostafa; Shama, A

doi:10.4103/1319-2442.318551

Cited by 5 publications

(3 citation statements)

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“…Chatrath et al reported that COVID-19 patients with HF developed AKI up to 45% vs. 24% in patients without HF [ 37 ]. Similarly, Tomasoni et al and Emad et al reported the incidence of AKI in COVID-19 patients as 28% and 30%, respectively [ 38 , 39 ]. We report the incidence of AKI as 5.56% in the AHF-COVID+ group vs. 2.9% in the AHF-COVID− group.…”

Section: Discussionmentioning

confidence: 94%

COVID-19 and Heart Failure with Preserved and Reduced Ejection Fraction Clinical Outcomes among Hospitalized Patients in the United States

Nasrullah

Gangu

Cannon

et al. 2023

Viruses

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Heart failure exacerbations impart significant morbidity and mortality, however, large- scale studies assessing outcomes in the setting of concurrent coronavirus disease-19 (COVID-19) are limited. We utilized National Inpatient Sample (NIS) database to compare clinical outcomes in patients admitted with acute congestive heart failure exacerbation (CHF) with and without COVID-19 infection. A total of 2,101,980 patients (Acute CHF without COVID-19 (n = 2,026,765 (96.4%) and acute CHF with COVID-19 (n = 75,215, 3.6%)) were identified. Multivariate logistic regression analysis was utilized to compared outcomes and were adjusted for age, sex, race, income level, insurance status, discharge quarter, Elixhauser co-morbidities, hospital location, teaching status and bed size. Patients with acute CHF and COVID-19 had higher in-hospital mortality compared to patients with acute CHF alone (25.78% vs. 5.47%, adjust OR (aOR) 6.3 (95% CI 6.05–6.62, p < 0.001)) and higher rates of vasopressor use (4.87% vs. 2.54%, aOR 2.06 (95% CI 1.86–2.27, p < 0.001), mechanical ventilation (31.26% vs. 17.14%, aOR 2.3 (95% CI 2.25–2.44, p < 0.001)), sudden cardiac arrest (5.73% vs. 2.88%, aOR 1.95 (95% CI 1.79–2.12, p < 0.001)), and acute kidney injury requiring hemodialysis (5.56% vs. 2.94%, aOR 1.92 (95% CI 1.77–2.09, p < 0.001)). Moreover, patients with heart failure with reduced ejection fraction had higher rates of in-hospital mortality (26.87% vs. 24.5%, adjusted OR 1.26 (95% CI 1.16–1.36, p < 0.001)) with increased incidence of vasopressor use, sudden cardiac arrest, and cardiogenic shock as compared to patients with heart failure with preserved ejection fraction. Furthermore, elderly patients and patients with African-American and Hispanic descents had higher in-hospital mortality. Acute CHF with COVID-19 is associated with higher in-hospital mortality, vasopressor use, mechanical ventilation, and end organ dysfunction such as kidney failure and cardiac arrest.

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Section: Discussionmentioning

confidence: 94%

COVID-19 and Heart Failure with Preserved and Reduced Ejection Fraction Clinical Outcomes among Hospitalized Patients in the United States

Nasrullah

Gangu

Cannon

et al. 2023

Viruses

View full text Add to dashboard Cite

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“…A high BAR value may be associated with a high urea value, which may be a consequence of acute kidney injury, a frequent complication in patients with COVID-19 [78]. In patients with acute kidney injury, it is possible to find fluid overload from the initial stages [79], which means that in severe cases that do not respond to fluid restriction and the use of diuretics, renal replacement therapy is indicated [80,81]. For this reason, the association between high urea values and higher mortality in patients with acute kidney injury [82,83] could explain our findings.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis

et al. 2022

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Fibrinogen-to-albumin ratio (FAR) and blood urea nitrogen-to-albumin ratio (BAR) are inflammatory biomarkers that have been associated with clinical outcomes of multiple diseases. The objective of this study is to evaluate the association of these biomarkers with the severity and mortality of COVID-19 patients. A systematic search was performed in five databases. Observational studies that reported the association between FAR and BAR values with the severity and mortality of COVID-19 patients were included. Random-effects models were used for meta-analyses, and effects were expressed as Odds Ratio (OR) and their 95% confidence intervals (CI). Publication bias was assessed using the Begg test, while the quality assessment was assessed using the Newcastle Ottawa Scale. A total of 21 studies (n = 7949) were included. High FAR values were associated with a higher risk of severity (OR: 2.41; 95% CI 1.41–4.12; p < 0.001) and mortality (OR: 2.05; 95% CI 1.66–2.54; p < 0.001). High BAR values were associated with higher risk of mortality (OR: 4.63; 95% CI 2.11–10.15; p < 0.001). However, no statistically significant association was found between BAR values and the risk of severity (OR: 1.16; 95% CI 0.83–1.63; p = 0.38). High FAR and BAR values were associated with poor clinical outcomes.

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“…AKI is associated with a higher mortality rate, with ICU admission and the need for mechanical ventilation 63 , 64 . The incidence of AKI is variable, ranging between 4.2% to 71.2% 65 , 66 , 67 , 68 , 69 , 70 . Two recent systematic reviews reported a pooled incidence rate of 6% and 11% respectively, with subgroup analysis indicating that US population suffered from more cases than Chinese 71 , 72 .…”

Section: Discussionmentioning

confidence: 99%

The Provision of Dental Care to COVID-19 Survivors: A Concise Review

Ngeow

Liszen

Yang

et al. 2022

International Dental Journal

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Incidence and Outcomes of Acute Kidney Injury in Critically Ill Patients with Coronavirus Disease 2019

Cited by 5 publications

References 0 publications

COVID-19 and Heart Failure with Preserved and Reduced Ejection Fraction Clinical Outcomes among Hospitalized Patients in the United States

COVID-19 and Heart Failure with Preserved and Reduced Ejection Fraction Clinical Outcomes among Hospitalized Patients in the United States

Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis

The Provision of Dental Care to COVID-19 Survivors: A Concise Review

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