Incidence and long‐term survival of patients with de novo head and neck carcinoma after liver transplantation

Coordes, Annekatrin; Albers, Andreas E.; Lenarz, Minoo; Seehofer, Daniel; Puhl, Gero; Pascher, Andreas; Neuhaus, R.; Pratschke, Johann; Ανδρέου, Ανδρέας

doi:10.1002/hed.23943

Cited by 17 publications

(16 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Head and neck malignancies after SOT are inclined to affect younger recipients, and often have a more aggressive behavior, a worse prognosis [ 136 , 137 ]. Annekatrin et al reported that 33 out of 2040 liver recipients developed de novo head and neck malignancies, and the median age at liver transplantation was 51 years (17-64 years) and the median time of diagnosis of HNSCC after transplantation was 7 years (1-25 years), it suggested that solid organ transplantation is a possible risk factor of young-onset HNSCC [ 138 ].…”

Section: Immunocompromisementioning

confidence: 99%

The etiologic spectrum of head and neck squamous cell carcinoma in young patients

et al. 2016

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC), accounting for more than 80% in head and neck malignancies, kills thousands of people a year in the world. Despite most of the patients are more than 45, and the occurrences of head and neck cancer shows a decreasing trend; however, horribly, the incidences of the patients under 45 years old is steadily increasing. Hence, it's of vital importance to get more pathogen information about risk factors of HNSCC in children and young adults. This review outlines the etiologic spectrum of HNSCC, especially oral/oropharyngeal squamous cell carcinoma, in patients under 45 years of age.

show abstract

Section: Immunocompromisementioning

confidence: 99%

The etiologic spectrum of head and neck squamous cell carcinoma in young patients

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Most studies addressing head and neck cancers in transplant patients report data collected in countries outside the United States (U.S.), where tumor registries are more easily cross-matched. [7][8][9][10][11]13,14 The reported incidence of all head and neck cancers at most centers is 6-7%, while non-cutaneous head and neck cancers are 1%. U.S. reports show lower rates, but the identification of tumors is likely less complete.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Transplant patients are known to have an increased risk for many types of tumors, especially dermatologic cancers frequently found in the head and neck region. [7][8][9][10][11][12][13][14][15] One group of patients at particular risk for post-transplant cancer are liver transplant patients because of the high incidence of alcohol abuse and tobacco use among this population. 16 Chronic exposure to these noxious substances has led to several published reports.…”

Section: Introductionmentioning

confidence: 99%

“…16 Chronic exposure to these noxious substances has led to several published reports. 7,8,14 This study seeks to determine the incidence of head and neck cancer in a large population of liver transplant recipients who all received antibody-based immunosuppression induction.…”

Section: Introductionmentioning

confidence: 99%

“…For non-cutaneous cancers, there were 25 cases, most commonly found in the larynx(7), oral cavity (5), hypopharynx(5), and oropharynx (4). One patient was diagnosed simply with "throat cancer" at an outside facility, and died shortly thereafter with no other informationavailable.…”

mentioning

confidence: 99%

See 2 more Smart Citations

De Novo Head and Neck Cancer After Liver Transplant With Antibody-Based Immunosuppression Induction

Graham

Mella

Mangus

2018

Transplantation Proceedings

View full text Add to dashboard Cite

show abstract

High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue

et al. 2022

View full text Add to dashboard Cite

Objective(s) There has been a disproportionate increase in the incidence of young patients with squamous cell carcinoma of the oral tongue (SCCOT). The purpose of this study was to compare young patients to older patients with SCCOT without prior drinking or smoking history as this population is poorly characterized in the literature. Methods A retrospective review of patients presenting to our institution with SCCOT was performed. The clinical and pathologic characteristics, as well as, outcomes were compared between younger patients (age ≤45) and older patients (age >45). Outcome analysis was performed using Kaplan Meier method. Multivariable Cox proportional hazard models were performed for age and stage. Results Eighty‐two patients (38 young, 44 old) were included in this study. Median follow‐up was 29.4 months. When compared to the older cohort (age >45), the younger cohort (age ≤45) demonstrated lower rates of 5‐year locoregional control (LC) (79.6% vs. 52.5%, p = 0.043) and distant metastasis‐free survival (88.1% vs. 61.8%, p = 0.006). Both cohorts demonstrated similar overall survival rates (55.5% vs. 58.1%) and disease‐specific survival (66.2% vs. 58.1%). Of patients experiencing locoregional failure with available radiation therapy plans and PET scans in younger cohorts (n = 7), 100% demonstrated in‐field failures. Multivariable Cox proportional hazards demonstrated age was an independent predictor of DMFS (p = 0.004) and the advanced stage was a predictor of DSS (p = 0.03). Conclusions Young, nondrinker, nonsmokers with SCCOT demonstrate high rates of locoregional recurrence, distant metastasis, and in‐field failures. Future studies are warranted to determine underlying mechanisms driving pathogenesis in this unique cohort. Level of Evidence 3 Laryngoscope, 133:1110–1121, 2023

show abstract

Incidence and long‐term survival of patients with de novo head and neck carcinoma after liver transplantation

Abstract: Early diagnosis and surgical treatment of de novo HNSCC are crucial to the outcome. HNSCC risk should be taken into close consideration during posttransplantation follow-up examinations, especially among patients with a positive history of smoking and alcohol consumption.

Cited by 17 publications

References 49 publications

The etiologic spectrum of head and neck squamous cell carcinoma in young patients

The etiologic spectrum of head and neck squamous cell carcinoma in young patients

De Novo Head and Neck Cancer After Liver Transplant With Antibody-Based Immunosuppression Induction

High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue

Contact Info

Product

Resources

About