Incidence and Epidemiology of Adhesive Capsulitis During the Covid-19 Pandemic

Mello, Danilo Passaro Pires de; CORBIN, JYOTIS NATACHA BRITO; HOLANDA, LETÍCIA SAKA; Pascarelli, Luciano; NISHIMURA, EDUARDO MISAO; ALMEIDA, THIAGO BERNARDO CARVALHO DE

doi:10.1590/1413-785220233101e261132

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…[ 18 ] A cross-sectional study found that the chance of developing FS in patients with Hypothyroidism was 2.69 times higher than that of the normal population [ 10 ] and this chance may increase to 5 times during the COVID-19 pandemic. [ 36 ] Kumar et al [ 37 ] proposed that diabetes and thyroid diseases are characterized by a pro-inflammatory state, elevated levels of inflammatory cytokines, and increased fibrosis, leading to an inflammatory response in the shoulder joint, promoting fibrosis in the muscles around the shoulder, and further increase the risk of developing FS.…”

Section: Discussionmentioning

confidence: 99%

“…Different studies have reported conflicting findings regarding this relationship. One study did not find a significant correlation between AIH and FS, [ 36 ] but another study suggested a 1.22 times higher risk of developing FS in AIH patients during a 7-year follow-up. [ 11 ] These discrepancies could be attributed to factors such as unmeasured confounders and variations in sample sizes among different studies.…”

Section: Discussionmentioning

confidence: 99%

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Gene association analysis to determine the causal relationship between immune-mediated inflammatory diseases and frozen shoulder

Zhou,

Yin,

Wang

et al. 2024

Medicine

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Multiple studies have indicated a potential correlation between immune-mediated inflammatory diseases (IMIDs) and Frozen shoulder (FS). To explore the genetic causal relationship between IMIDs and FS using 2-sample Mendelian randomization (MR) analysis. Genome-wide association study (GWAS) summary data for FS were obtained from Green’s study, while data for 10 IMIDs were sourced from the FinnGen Consortium. The MR analysis was performed using inverse variance weighting, MR Egger, and weighted median methods. IVW, as the primary MR analysis technique, was complemented with other sensitivity analyses to validate the robustness of the results. Additionally, reverse MR analysis was further conducted to investigate the presence of reverse causal relationships. In the forward MR analysis, genetically determined 4 IMIDs are causally associated with FS: rheumatoid arthritis (odds ratio [OR] (95% confidence interval [95% CI]) = 1.05 [1.02–1.09], P < .01); type 1 diabetes (OR [95% CI] = 1.06 [1.03–1.09], P < .01); hypothyroidism (OR [95% CI] = 1.07 [1.01–1.14], P = .02); and Celiac disease (OR [95% CI] = 1.02 [1.01–1.04], P = .01). However, no causal relationship was found between 6 IMIDs (autoimmune hyperthyroidism, Crohn disease, ulcerative colitis, psoriasis, sicca syndrome and systemic lupus erythematosus) and FS. Sensitivity analyses did not detect any heterogeneity or horizontal pleiotropy. In the reverse MR analysis, no causal relationship was observed between FS and IMIDs. In conclusion, this MR study suggests a potential causal relationship between rheumatoid arthritis, type 1 diabetes, hypothyroidism, and Celiac disease in the onset and development of FS. Nevertheless, more basic and clinical research will be needed in the future to support our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gene association analysis to determine the causal relationship between immune-mediated inflammatory diseases and frozen shoulder

Zhou,

Yin,

Wang

et al. 2024

Medicine

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“…Mello et al, through a retrospective analysis of 1,983 patients with shoulder disorders during the COVID-19 pandemic, identified a 2.41-fold surge in AC cases compared to the preceding year. Notably, patients with anxiety exhibited a substantially heightened 14-fold risk of developing AC during the pandemic (30). In a prospective study, Toprak et AC and 72 healthy controls, examining anxiety, depression, sleep quality, and quality of life in patients with AC relative to controls.…”

Section: Discussionmentioning

confidence: 99%

Anxiety disorders and adhesive capsulitis: a bidirectional Mendelian randomization study

Ouyang,

Dai

2024

Front. Immunol.

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BackgroundPrevious epidemiological investigations and related research efforts consistently have outlined an observable association between anxiety disorders and adhesive capsulitis (AC). However, the intricate nature of the causal connection between these entities has yet to be fully clarified. Therefore, this investigative study aims to thoroughly examine and delineate the causal interrelationship between anxiety disorders and AC using a bidirectional, two-sample Mendelian randomization (MR) approach.MethodsTo pursue this inquiry, datasets related to anxiety disorders and AC were meticulously obtained from a publicly accessible genomewide association study. Instrumental variables, in the form of single nucleotide polymorphisms, were subsequently identified, undergoing a rigorous screening process that included intensity adjustment and the amelioration of linkage disequilibrium. The primary analytical tool for scrutinizing causal ramifications was the inverse variance weighting (IVW) methodology, complemented by supplementary analytical techniques such as weighted median, MR-Egger, simple mode, and weighted mode. Additionally, evaluations of heterogeneity and pleiotropy were meticulously conducted. Heterogeneity was assessed using Cochran’s Q-test in conjunction with the IVW and MR-Egger methods, while pleiotropy was appraised through the MR-Egger intercept and MR-PRESSO analysis methods. A leave-one-out analysis was undertaken to enhance the reliability of our findings. Finally, AC was utilized to infer reverse causality concerning the risk of anxiety disorders.ResultsThe random effects IVW analysis results yielded statistical significance (P = 9.362 × 10-6), demonstrating a causal link between anxiety disorders and elevated susceptibility to AC, reflected in an odds ratio of 1.267 (95% confidence interval: 1.141–1.407). Conversely, the inverse MR analysis predominantly produced null findings. Furthermore, sensitivity analyses underscored the robustness of our conclusions.ConclusionIn summary, our meticulously conducted study unequivocally supports the presence of a causal connection between anxiety disorders and an increased propensity for AC. Unfortunately, the reverse MR analysis failed to provide compelling evidence indicative of a reciprocal genetic causative relationship between AC and anxiety disorders.

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“…[24] By retrospectively analyzing 1983 patients with frozen shoulder during the novel coronavirus epidemic, Mello et al found a significantly increased risk of 8.8-fold (P < .001) of developing frozen shoulder in depressed patients. [25] However, Floren et al prospectively included 77 patients who underwent arthroscopic rotator cuff repair. At 6-month follow-up, eight patients were diagnosed with frozen shoulder (group A) and 65 patients had a satisfactory range of motion of the joint (group B), and by comparing the 2 groups depression was found not to be a risk factor for the development of frozen shoulder after rotator cuff repair.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The causal relationship between depression and frozen shoulder: A two-sample Mendelian randomization

Deng,

Wei

2023

Medicine

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To investigate the causal relationship between depression and frozen shoulder using a Mendelian randomization (MR) approach. Pooled data from a large-scale genome-wide association study were used. Genetic loci that were independent of each other and associated with depression and frozen shoulder in populations of European ancestry were selected as instrumental variables. Inverse variance weighting was used as the primary analysis method. Weighted median and MR-Egger were used as complementary analysis methods to assess causal effects. To explore the causal relationship between depression and frozen shoulder. Sensitivity test analysis was performed using heterogeneity test, multiple validity test, and leave-one-out analysis to explore the robustness of the results. Inverse variance weighting results showed an odds ratio (95% confidence interval) of 1.18 (0.91–1.53), P = .204, indicating that depression was not causally related to the development of frozen shoulder. And the test revealed no heterogeneity and pleiotropy, and the sensitivity analysis also showed robust results. In this study, genetic data were analyzed and explored using a two-sample MR analysis, and the results showed no causal relationship between depression and the occurrence of frozen shoulder, requiring the inclusion of a larger sample for the study.

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Incidence and Epidemiology of Adhesive Capsulitis During the Covid-19 Pandemic

Cited by 6 publications

References 13 publications

Gene association analysis to determine the causal relationship between immune-mediated inflammatory diseases and frozen shoulder

Gene association analysis to determine the causal relationship between immune-mediated inflammatory diseases and frozen shoulder

Anxiety disorders and adhesive capsulitis: a bidirectional Mendelian randomization study

The causal relationship between depression and frozen shoulder: A two-sample Mendelian randomization

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