Incidence and Costs of Adverse Drug Reactions During Hospitalisation

Dormann, Harald; Muth-Selbach, Uta; Krebs, Sabine; Criegee-Rieck, Manfred; Tegeder, Irmgard; Schneider, H. T.; Hahn, Eckhart G.; Levy, Micha; Brune, Kay; Geißlinger, Gerd

doi:10.2165/00002018-200022020-00007

Cited by 141 publications

(55 citation statements)

References 27 publications

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“…Considering the severity of the ADRs, majority were moderate similar to the results of some studies [3,5,28] but different from the results of certain other studies [36,37] in which reported ADRs were more often mild. Only a small percentage of the reactions were severe in nature.…”

Section: Discussioncontrasting

confidence: 66%

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Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

et al. 2010

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AbstractThe aim of the present study was to characterize the pattern of adverse drug reactions (ADRs) reported in a university teaching hospital in south-east Serbia. The study was conducted based on ADRs reported during a six-month period to the ADR reporting unit of the university clinical center. Evaluation of data was done for various parameters, such as patient demographics, drug and reaction characteristics, and outcome of reactions. Assessment was also done for causality, severity and predisposing factors. During the 6-month study period, 44 ADRs were reported, with an overall incidence of 0.33%. No significant difference was seen in the overall incidence of ADRs observed in males and females. Incidence of ADRs among elderly (43.2%) and older (25%) adults was significantly higher than in other age groups. Type A reactions (66.7%) accounted for majority of the reports. The most commonly affected organ system was the renal system, (22.7%) with hyperkalemia as the only reported reaction. ACE inhibitors (48.6%) were the drug class most commonly involved, where fosinopril (25.7%) was the individual drug most frequently reported. Additional treatment was pursued for management of ADRs in majority (52.3%) of the reports. In 52.3 % of the reports, the patient had recovered from the reaction by the time of evaluation. Upon causality assessment, the majority of the reports were rated as probable (43.2%). Mild and moderate reactions accounted for 43.2% and 54.6%, respectively. In 36.3% of the reports, the reaction was considered to be preventable. The most common predisposing factors were polypharmacy and multiple disease state. The pattern of ADRs reported in our hospital is comparable to the results of studies conducted in hospital set up elsewhere. Our evaluations revealed opportunities for intervention to ensure safer drug use.

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Section: Discussioncontrasting

confidence: 66%

“…ADRs are a frequent cause of hospitalization, and occur often in hospitalized patients [3][4][5][6][7]. Around 6% of hospital admissions are estimated to be due to ADRs and about 6-15% of hospitalized patients experience a serious ADR [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

et al. 2010

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“…(6,8) Furthermore, ADRs may occur in 6-20% of patients admitted to hospitals, increasing the hospitalization period, thus increasing the costs associated with health care. (9) ADRs have a direct impact on National Health Services (SNS) costs and even an indirect impact on patients and family in economic, social and psychological way.…”

Section: Introduction In Pharmacovigilancementioning

confidence: 99%

“…ADRs can have a significantly impact on hospitals' budget and, consequently, can lead to important charges to healthcare systems. (9) Because not all adverse drug reactions of a product are known once it's granted marketing authorization, pharmacovigilance is needed to learn more about possible harmful effects of a drug. According to WHO, (1) pharmacovigilance plays a vital role in ensuring that healthcare professionals, such as physicians and pharmacy professionals, together with the patient, have enough information to make an educated decision when it comes to choosing a drug for treatment.…”

Section: Introduction In Pharmacovigilancementioning

confidence: 99%

Are patients ready to take part in the Pharmacovigilance system? a portuguese preliminary study concerning adr reporting

Matos

Hunsel

Joaquim

2015

Clinical Therapeutics

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“…Data are usually collected by hospital pharmacies, quality improvement and risk management departments, and physician peer review systems, although underreporting is common. Medication errors and adverse drug reactions are common and costly [3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Position Statement: Medical Toxicologist Participation in Medication Management and Safety Systems

2015

J. Med. Toxicol.

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Incidence and Costs of Adverse Drug Reactions During Hospitalisation

Abstract: Computer monitoring is an effective method for improving the detection of adverse drug reactions in inpatients. The excess length of stay and costs caused by adverse drug reactions are substantial and might be considerably reduced by earlier detection.

Cited by 141 publications

References 27 publications

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

Are patients ready to take part in the Pharmacovigilance system? a portuguese preliminary study concerning adr reporting

Position Statement: Medical Toxicologist Participation in Medication Management and Safety Systems

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