Incidence and Clinical Impact of Stroke Complicating Transcatheter Aortic Valve Implantation: Results From the <scp>G</scp>erman <scp>TAVI</scp><scp>R</scp>egistry

Werner, Nicolas; Zeymer, Uwe; Schneider, Steffen; Bauer, Timm; Gerckens, Ulrich; Linke, Axel; Hamm, Christian W.; Sievert, Horst; Eggebrecht, Holger; Zahn, Ralf

doi:10.1002/ccd.26612

Cited by 61 publications

(43 citation statements)

References 42 publications

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“…Eggebrecht et al showed in a meta-analysis of around 10,000 patients an increased mortality after stroke (>3.5-fold) 19 . Similar results could be found in the German TAVI Registry with a fivefold increase in the in-hospital mortality rate 20 . Differences between first- and new-generation devices have prompted a decrease in CVE appearance.…”

Section: Current Advancessupporting

confidence: 87%

Recent advances in understanding and managing aortic stenosis

Hemelrijck¹,

Taramasso²,

Carlo³

et al. 2018

F1000Res

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Over the last few years, treatment of severe symptomatic aortic stenosis in high-risk patients has drastically changed to adopt a less-invasive approach. Transcatheter aortic valve implantation (TAVI) has been developed as a very reproducible and safe procedure, as shown in many trials. When compared to surgery, TAVI has produced superior, or at least comparable, results, and thus a trend to broaden treatment indications to lower-risk patients has erupted as a natural consequence, even though there is a lack of long-term evidence. In this review, we summarize and underline aspects that still remain unanswered that are compulsory if we want to enhance our understanding of this disease.

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Section: Current Advancessupporting

confidence: 87%

Recent advances in understanding and managing aortic stenosis

Hemelrijck¹,

Taramasso²,

Carlo³

et al. 2018

F1000Res

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“…Patients with an early CVE (within 30-day) after TAVI had significantly higher mortality at 30-day and 1-year as compared to those without CVE, as shown in several studies ( 5 , 9 , 20 , 21 , 48 – 50 ). Eggebrecht et al also reported a 3.5 times higher 30-day mortality after stroke in a large meta-analysis.…”

Section: Prognosis Value On Mortality Morbidity and Neurocognitive Fsupporting

confidence: 55%

Cerebrovascular Events After Transcatheter Aortic Valve Implantation

Armijo

Nombela‐Franco

Tirado‐Conte

2018

Front. Cardiovasc. Med.

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Transcatheter aortic valve implantation (TAVI) has emerged as an alternative less invasive treatment for patients with symptomatic severe aortic stenosis. Despite the technological development and knowledge improvement in recent years, neurological complications remain a concern, especially with the expansion of the technique toward younger and lower risk patients. Clinical cerebrovascular events have an important impact on patients' morbidity and mortality with a multifactorial origin. While cerebral microembolizations during TAVI is a universal phenomenon and embolic protection devices have been developed in an attempt to reduce them, their clinical utility remains unclear. We review the current evidence on cerebrovascular events associated with TAVI and potential preventive strategies.

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“…Stroke is a feared complication that has been linked to worse clinical outcomes after TAVR . In fact, embolic stroke is more commonly encountered after TAVR procedures than after conventional surgical AVR, especially comparing outcomes among high‐risk patients .…”

Section: Discussionmentioning

confidence: 99%

Alternative access for transcatheter aortic valve replacement in older adults: A collaborative study from France and United States

Damluji

Murman

Byun

et al. 2018

Cathet Cardio Intervent

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Although regional differences exist in the choice of alternative access techniques, centers with high technical expertise can provide a safe alternative to traditional TF TAVR. TAo TAVR was associated with higher in-hospital mortality than other non-TF approaches, and this may have reflected patient rather than procedural factors. All alternative access techniques had similar mortality rates and clinical outcomes at one-year follow-up. Trans-carotid access is safe and feasible compared to other non-TF access techniques.

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Incidence and Clinical Impact of Stroke Complicating Transcatheter Aortic Valve Implantation: Results From the German TAVIRegistry

Cited by 61 publications

References 42 publications

Recent advances in understanding and managing aortic stenosis

Recent advances in understanding and managing aortic stenosis

Cerebrovascular Events After Transcatheter Aortic Valve Implantation

Alternative access for transcatheter aortic valve replacement in older adults: A collaborative study from France and United States

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