Incidence and behaviour of Tn916‐like elements within tetracycline‐resistant bacteria isolated from root canals

Abstract

The tet(M) gene is present in the majority of tetracycline-resistant bacteria isolated in this study and the conjugative transposon Tn916 has been shown to be responsible for the support and transfer of this gene in some of the bacteria isolated.

Antibiotic Resistance Gene Transfer between Streptococcus gordonii and Enterococcus faecalis in Root Canals of Teeth Ex Vivo

“…Transfer of a mobile Tn916-like transposon element encoding tetracycline resistance from a Neisseria sp endodontic isolate to the laboratory strain E. faecalis JH2-2 was recently shown using filter mating (37). In the present study, confirmation of bidirectional transfer of an erythromycin resistance determinant on the conjugative plasmid pAM81 between S. gordonii and E. faecalis supports the hypothesis that horizontal exchange of antibiotic resistance can occur between different bacterial species in root canals.…”

Distribution of Tetracycline and Erythromycin Resistance Genes Among Human Oral and Fecal Metagenomic DNA

“…9,20,22,23,31,51 The wide-spread distribution of tet(M) can be explained in part by its presence on Tn916-like elements. 13 Tn916-like elements have been found in many oral species, 6,27,28,34,38,42 and they have been shown to readily transfer to and among oral streptococci 28,34,52 and enterococci, 6 and have been shown to transfer in microcosm dental plaques. 38,41 These elements have also been detected in human gut isolates 2 and have been shown to transfer in the guts of gnotobiotic rats and mice.…”

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

“…Evidence suggests that ribosome protection does not confer resistance to tigecycline (301). To date, two ribosome protection protein genes, otr(A) and tet(M), have been described for tetracycline-resistant mycobacteria (279,328), although their role in tetracycline resistance in these organisms has yet to be confirmed. Efflux pumps (or putative efflux pumps) that are associated with increased resistance to tetracyclines appear to be common in mycobacteria.…”