2017
DOI: 10.3389/fphys.2017.00363
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Incidence and Antimicrobial Sensitivity Profiles of Normal Conjunctiva Bacterial Flora in the Central Area of China: A Hospital-Based Study

Abstract: Objective: To study the distribution and patterns of resistance to antimicrobial agents of normal conjunctival bacteria. Materials and Methods:Conjunctival specimens were collected from 8,224 patients and then cultured, which underwent antimicrobial susceptibility test following standard methods. Patients with infectious symptoms such as erythema or oedema and those using systemic or topical antibiotics within 1 month were excluded.Results: In this study, the incidence of isolated bacteria was 24.2%. The middl… Show more

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Cited by 26 publications
(25 citation statements)
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“…S. aureus exhibited significantly lower susceptibility (P≤0.05) to tetracycline, erythromycin, azithromycin, clindamycin, mupirocin, and fusidic acid than CONS. However, the latter demonstrated higher resistant rate to the remaining antibiotics consistently with Tao et al reported outcomes [56]. Comparing to CONS with resistance rate average, 20.3%, S. aureus showed lower resistance rate with 0.0-10 % to quinolone.…”
Section: Discussionsupporting
confidence: 67%
“…S. aureus exhibited significantly lower susceptibility (P≤0.05) to tetracycline, erythromycin, azithromycin, clindamycin, mupirocin, and fusidic acid than CONS. However, the latter demonstrated higher resistant rate to the remaining antibiotics consistently with Tao et al reported outcomes [56]. Comparing to CONS with resistance rate average, 20.3%, S. aureus showed lower resistance rate with 0.0-10 % to quinolone.…”
Section: Discussionsupporting
confidence: 67%
“…and S. pneumoniae. This bacterial profile is very different from that of adult, where Streptococcus is less frequently found in the conjunctival sac [20], suggesting that Streptococcus is not only common in the nasopharynx of children, but also in the conjunctival sac, especially in infants under 6 years old. In addition, the difference in bacterial profiles between children and adults may be attributed to their difference in the immunity, tear composition, tear fluid hydrodynamics, exposing environment, antibiotics use, bacterial flora in the skin and upper respiratory tract [21,22].…”
Section: Discussionmentioning
confidence: 58%
“…Previous studies have reported positive detection rates for bacteria in lacrimal secretion samples from chronic dacryocystitis patients of 48.3-96% [5][6][7][8][9][10][11][12][13][14][15], with rates of 20.6-87.0% in normal conjunctival sac secretion samples [16][17][18]. Gram-negative bacteria were found in 12.1-48.6% of lacrimal secretion samples from chronic dacryocystitis patients and 1.7-8.9% of normal conjunctival sac secretions.…”
Section: Discussionmentioning
confidence: 99%
“…Gram-negative bacteria were found in 12.1-48.6% of lacrimal secretion samples from chronic dacryocystitis patients and 1.7-8.9% of normal conjunctival sac secretions. Similarly, anaerobic bacteria were found in 10.7-18.6% and 0-16.5% of the two types of samples, respectively [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Therefore, the results of the current study are fairly consistent with previous findings, with bacteria detected in 61.9% of the lacrimal duct secretion samples from chronic dacryocystitis patients and 50.9% of the non-infectious eye disease patients (P \ 0.05).…”
Section: Discussionmentioning
confidence: 99%