Incidence and Antimicrobial Sensitivity Profiles of Normal Conjunctiva Bacterial Flora in the Central Area of China: A Hospital-Based Study

Tao, Hua; Wang, Juan; Li, Lei; Zhang, Hui Zhi; Chen, Meng Ping; Le, Li

doi:10.3389/fphys.2017.00363

Cited by 33 publications

(44 citation statements)

References 16 publications

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“…S. aureus exhibited significantly lower susceptibility (P≤0.05) to tetracycline, erythromycin, azithromycin, clindamycin, mupirocin, and fusidic acid than CONS. However, the latter demonstrated higher resistant rate to the remaining antibiotics consistently with Tao et al reported outcomes [56]. Comparing to CONS with resistance rate average, 20.3%, S. aureus showed lower resistance rate with 0.0-10 % to quinolone.…”

Section: Discussionsupporting

confidence: 67%

Incidence and susceptibility patterns of urine bacterial flora in young females

Shami¹,

Al-Mijalli²,

Somily

et al. 2020

Preprint

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Background: It has been established that the urinary tract is not sterile, however, research related to the study of urine bacteria are limited. Our work aims to study the frequency and patterns of resistance of normal urinary aerobic bacterial flora.Methods: Clean catch midstream urine specimens were collected from 120 young healthy females, and then cultured. Identification of bacteria and antimicrobial susceptibility were done by means of Biomérieux VITEK® 2 automated systems.Subjects who have undergone antimicrobial treatment in one month weren't included.Results: The incidence of positive bacterial cultures was 54.2%, of which 21.5% were ploymicrobial. 107 bacterial isolates that encompass 12 genera and 27 species that were predominated by Gram-positive bacteria (72%) were cultivated. Staphylococcaceae (46.1%) and Enterobacteriaceae (17.8%) were the most frequently isolates among Gram positive and Gram negative bacteria respectively, from them 36 species have been identified as b lactamase producers. The top four frequently isolated bacteria are Micrococcus species (16%), Staphylococcus haemolyticus (13.2%), Staphylococcus aureus (10%), and Klebsiella pneumoniae (10%). Twenty two bacterial species weresubjected to antimicrobial susceptibility testing by using broad and narrow spectrum antibiotics and antimicrobials. Ampicillin showed the lowest susceptibility rate against Gram positives, followed by erythromycin and azithromycin. The lesser antimicrobial susceptibility potential among Gram negative bacteria was exhibited against ampicillin, followed by piperacillin and cefotaxime. Conclusion:Our findings emphasize the importance of highlighting urine bacterial flora in research especially those related to susceptibility patterns, employing more advanced culture methods as multiple drug resistant bacteria were isolated.

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Section: Discussionsupporting

confidence: 67%

Incidence and susceptibility patterns of urine bacterial flora in young females

Shami¹,

Al-Mijalli²,

Somily

et al. 2020

Preprint

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“…and S. pneumoniae. This bacterial profile is very different from that of adult, where Streptococcus is less frequently found in the conjunctival sac [20], suggesting that Streptococcus is not only common in the nasopharynx of children, but also in the conjunctival sac, especially in infants under 6 years old. In addition, the difference in bacterial profiles between children and adults may be attributed to their difference in the immunity, tear composition, tear fluid hydrodynamics, exposing environment, antibiotics use, bacterial flora in the skin and upper respiratory tract [21,22].…”

Section: Discussionmentioning

confidence: 58%

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Zhang

Zhou

et al. 2020

BMC Pediatr

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Background: To investigate bacterial flora and antibiotics susceptibility of Streptococcus pneumoniae isolated from the conjunctival sac of heathy children. Methods: Bacteria were isolated from the secretions of conjunctival sac of healthy children between 2015 and 2018. Antimicrobial susceptibility of isolated S. pneumoniae strains were determined using microbroth dilution method. Results: The sac secretions were collected from a total of 6440 children. 1409 samples presented bacterial growth, accounting for 21.8% of the samples. Among the 22 bacterial species isolated, 528 samples presented Grampositive Staphylococcus spp. growth, accounting for 37.4% of the isolates, followed by Corynebacterium spp., counting for 30% of the isolates and Streptococcus pneumoniae, counting for 21.4% of the isolates. Antibiotics susceptibility tests showed that the majority of S. pneumoniae isolates were sensitive to most antibiotics tested. However, 72.8 and 81.2% of the isolates were resistant to erythromycin and tetracycline, respectively, and over 10% of them were resistant to gentamicin, tobramycin and rifampicin. Conclusions: The bacterial flora of healthy children is mainly consisted of Gram-positive bacteria belonging to Corynebacterium spp. and Streptococcus spp.; most of S. pneumoniae isolates were sensitive to antibiotics except erythromycin and tetracycline.

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“…Acute bacterial conjunctivitis accounts for approximately 50–75% of all conjunctivitis cases 4 , 5 . Streptococcus pneumoniae is one of the top three most commonly isolated microorganisms from normal conjunctival flora 6 . The reported prevalence of S. pneumoniae in healthy conjunctiva ranges from 0 to 4.2% 6 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Streptococcus pneumoniae in conjunctival flora and association with nasopharyngeal carriage among children in a Vietnamese community

Mohamed

Toizumi

Uematsu

et al. 2021

Sci Rep

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Conjunctival pneumococcal serotypes among members of a community have not been investigated well. We determined the prevalence and association of Streptococcus pneumoniae in the nasopharynx and conjunctiva among children in a community before pneumococcal conjugate vaccine introduction. In October 2016, conjunctival and nasopharyngeal swabs were collected from children (< 24 months old) and nasopharyngeal swabs from mothers in Nha Trang, Vietnam. Quantitative lytA PCR and DNA microarray were performed to detect and serotype S. pneumoniae. The association between S. pneumoniae in the nasopharynx and conjunctiva was evaluated using multivariable logistic regression model. Among 698 children, 62 (8.9%, 95% CI 6.9–11.2%) were positive for S. pneumoniae in the conjunctiva. Non-encapsulated S. pneumoniae were most commonly identified, followed by serotypes 6A, 6B, and 14. Nasopharyngeal and conjunctival detection were positively associated (aOR 47.30, 95% CI 24.07–92.97). Low birth-weight, day-care attendance, and recent eye symptoms were independently associated with S. pneumoniae detection in the conjunctiva (aOR 11.14, 95% CI 3.76–32.98, aOR 2.19, 95% CI 1.45–3.31, and aOR 3.59, 95% CI 2.21–5.84, respectively). Serotypes and genotypes in the conjunctiva and nasopharynx matched in 87% of the children. Three mothers’ nasopharyngeal pneumococcal samples had matched serotype and genotype with their child’s in the conjunctiva and nasopharynx. S. pneumoniae presence in nasopharynx and conjunctiva were strongly associated. The high concordance of serotypes suggests nasopharyngeal carriage may be a source of transmission to the conjunctiva.

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Incidence and Antimicrobial Sensitivity Profiles of Normal Conjunctiva Bacterial Flora in the Central Area of China: A Hospital-Based Study

Cited by 33 publications

References 16 publications

Incidence and susceptibility patterns of urine bacterial flora in young females

Incidence and susceptibility patterns of urine bacterial flora in young females

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Prevalence of Streptococcus pneumoniae in conjunctival flora and association with nasopharyngeal carriage among children in a Vietnamese community

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