Inappropriate Secretion of Antidiuretic Hormone and Transient Hypertension Associated with Guillain-Barré Syndrome

Kaneko, Kazunari; Shioya, T.; Yabuta, Keijiro

doi:10.1159/000120477

Cited by 11 publications

(11 citation statements)

References 8 publications

(9 reference statements)

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“…Robertson divided the SIADH into three types of abnormal vasopressin (VAS) release during hypertonic saline infusion [14,18]: type A, high, inconsistent fluctuations unrelated to increases in plasma sodium; type B, a slow regular release, which is also unaltered by increases in plasma sodium; type C, a quick progressive increase in plasma VAS that closely correlates with plasma sodium as it rises towards the normal range; there is also another kind, type D, that appears in a low percentage of patients, where there is no demonstrable defect in the osmoregulation of VAS and the cause of inappropriate antidiuresis is unclear [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the presence of VAS, AGII, and TH and their implication in cardiovascular, salt water balance and blood pressure regulation have long been described in the hypothalamus in man and different animal species [7][8][9][10]. Several authors have also described the detection of tyrosine hydroxylase-immunoreactivity and vasopressin mRNA and ANGII in the hypothalamus that could be related to hypertension and SIADH [11][12][13][14]. Furthermore, the subfornical organ (SFO) is a circumventricular organ located in the medial plane, below the commissure of fornix (Figures 1(a) and 1(b)), which contains neurons, glia, and a dense plexus of highly fenestrated capillaries, and is covered by an ependymal layer [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH

Carmona-Calero

González-Toledo

Castañeyra-Ruiz

et al. 2014

Advances in Endocrinology

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The syndrome of inappropriate antidiuretic hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolarity of urine where vasopressin and angiotensin II are implicated in the alteration of salt water balance and cardiovascular and blood pressure regulation. The aim of this study is to analyse the expression of substances related with cardiovascular and salt water regulation in the subfornical organ in a case of SIADH. Two brains, one taken from a 66-year-old man with SIADH and the other from a 63-year-old man without SIADH, were used. Immunohistochemical study was performed using anti-angiotensin II, antivasopressin, and anti-collagen-VI as primary antibodies. Angiotensin and vasopressin immunoreaction were found in neurons, in perivascular spaces, and in the ependymal layer in the subfornical organ in both cases. However, in the SIADH case, the angiotensin II and collagen-IV expression in the SFO were different suggesting this organ's possible participation in the physiopathology of SIADH.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH

Carmona-Calero

González-Toledo

Castañeyra-Ruiz

et al. 2014

Advances in Endocrinology

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“…Clinical reports of elevation in blood pressure in association with SIADH also exist. 27,28) Conivaptan is a combined V 1A /V 2 receptor antagonist 16,17) and the use of the dual antagonist has the theoretical advantage of reducing blood pressure elevated by excessive AVP.…”

Section: Discussionmentioning

confidence: 99%

A Novel Vasopressin Dual V1A/V2 Receptor Antagonist, Conivaptan Hydrochloride, Improves Hyponatremia in Rats with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

Wada

Matsukawa

Fujimori

et al. 2007

Biological & Pharmaceutical Bulletin

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The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a clinical state in which the secretion of antidiuretic hormone (ADH), also called arginine vasopressin (AVP), is not suppressed appropriately when plasma osmolality falls below the osmotic threshold and may lead to impaired renal water excretion, increased total body water, and hyponatremia. 1) SIADH is associated with a number of underlying clinical conditions, such as malignancy, lung disease, and central nervous system and hormonal disorders. 2)AVP is a peptide hormone that is released from the posterior pituitary gland in response to an increase in plasma osmolality and volume depletion. Three classes of specific receptor have been identified in the periphery. The vasopressin V 1A receptor, which has been identified in vascular smooth muscle cells, hepatocytes and platelets, and the vasopressin V 1B receptor, which is found predominantly in the anterior pituitary, are coupled to the phosphoinositide pathway and elevation of intracellular Ca 2ϩ . The vasopressin V 2 receptor, which is located in the kidney and the vascular endothelium, is coupled to the adenylate cyclase pathway, causing an increase in c-AMP.3) AVP elicits a potent water reabsorption effect in the collecting ducts of the kidney via the vasopressin V 2 receptors, as well as systemic vasoconstriction via the vasopressin V 1A receptors. [4][5][6] The facilitation of renal water reabsorption via the vasopressin V 2 receptor results in an increase in total body water, which in turn causes a decrease in blood sodium concentration and plasma osmolality. The increased total body water causes inhibition of sodium reabsorption in the proximal tubule via inhibition of the renin-angiotensin-aldosterone system, as well as elevation of glomerular filtration rate and facilitation of the secretion of atrial natriuretic peptide (ANP) from the atrium.7) These stimuli produce sustained urinary sodium excretion, and result in hyponatremia, the most common electrolyte disorder associated with SIADH. Clinical manifestations of hyponatremia range from mild symptoms, such as headache, nausea, and vomiting, to severe symptoms, such as disorientation, disturbed consciousness and seizures. 8) Although the treatment of hyponatremia should be directed at the primary underlying etiology of disorder, this is not always entirely possible. Thus, the general approach to the management of hyponatremia is normalization of blood sodium concentration by the prevention of water retention in the body. 9)One treatment used for acute severe hyponatremia is the intravenous administration of furosemide concomitantly with hypertonic saline. Diuretics are used in the treatment of chronic hyponatremia, however, resistance to loop diuretics such as furosemide is a common problem in hyponatremia patients.10) Further, loop diuretics may worsen hyponatremia and induce hypokalemia, a potentially serious electrolyte disorder that can result in the prolongation of QT interval and the subsequent risk of ventricular arrhyt...

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“…On the other hand, the presence of VAS, AGII and TH and their implication in cardiovascular, salt water balance and blood pressure regulation have long been described in the hypothalamus in man and different animal species [5][6][7][8]. Several author have also described the detection of tyrosine hydroxylase-immunoreactivity and vasopressin mRNA and ANGII in the hypothalamus that could be related with the hypertension and SIADH [9][10][11][12]. The aim of the present work is to analyze the hypothalamic distribution of vasopressin (VAS), AGII and Tyrosinehydroxylase (TH) in a case of SIADH.…”

Section: Introductionmentioning

confidence: 99%

Vasopressin, Angiotensin II and Tyrosine-Hydroxylase Expression in the Hypothalamus of the Syndrome of Inappropriate ADH: A Case Report

Carmona-Calero¹,

Castañeyra-Ruiz²,

González-Marrero³

et al. 2012

TOPATJ

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Abstract:The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolality of urine, and where vasopressin, angiotensin II and catecholamines are implicated in salt water balance, cardiovascular and blood pressure regulation. Therefore, the aim of this study is to analyze the hypothalamic distribution of vasopressin (VAS) Angiotensin II (AGII) and tyrosine-hydroxylase (TH) in a case of SIADH and compare it with a case without SIADH. Two hypothalamus taken from a 66 year-old man with SIADH, and the other from a 63 year-old man without SIADH, were used. An immunohistochemical study was performed using anti-VAS, anti-AGII and anti-TH as primary antibodies. The vasopressin immunoreactive material was mainly found in the supraoptic nucleus (SON) and paraventricular nucleus (PVN), but VAS was also shown in the periventricular nucleus, preoptic medial area, perifornical nucleus and hypothalamic lateral area. The AGII was also mainly found in the SON and PVN. The TH was found in the SON, PVN, arcuate nucleus, periventricular nucleus, perifornical nucleus, preoptic medial and lateral area. VAS was less intensive and in a lesser number of cells and fibres in the case of SIADH, as opposed to the AGII and TH which were similar in both cases.

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Inappropriate Secretion of Antidiuretic Hormone and Transient Hypertension Associated with Guillain-Barré Syndrome

Cited by 11 publications

References 8 publications

Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH

Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH

A Novel Vasopressin Dual V1A/V2 Receptor Antagonist, Conivaptan Hydrochloride, Improves Hyponatremia in Rats with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

Vasopressin, Angiotensin II and Tyrosine-Hydroxylase Expression in the Hypothalamus of the Syndrome of Inappropriate ADH: A Case Report

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