Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of  Syndrome of Inappropriate ADH

Carmona-Calero, Emilia M.; González-Toledo, Juan M.; Castañeyra-Ruiz, Leandro; González-Marrero, Ibrahim; Castañeyra-Ruiz, María; Paz-Carmona, Héctor de; Castañeyra-Ruiz, Agustín; Rancel-Torres, Nélida; Castañeyra-Perdomo, Agustín

doi:10.1155/2014/179795

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…The SFO is one of seven circumventricular organs in the brain that lack a traditional blood-brain barrier (BBB) in both humans and rodents (16,17,22,37). The permeability provided by this BBB deficiency makes it possible for the SFO to sense circulating factors (e.g., ANG II or prorenin) and electrolytes (e.g., salts) as well as interact with factors generated locally in the brain, allowing it to play a key role in blood pressure (BP) regulation and body fluid homeostasis (9,39,49,59,66). The SFO is also a major site of RAS activity (15,32,55,62).…”

Section: Introductionmentioning

confidence: 99%

Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans

Cooper

Trivedi

Yamamoto

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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The central nervous system plays an important role in essential hypertension in humans and in animal models of hypertension through modulation of sympathetic activity and Na and body fluid homeostasis. Data from animal models of hypertension suggest that the renin-angiotensin system in the subfornical organ (SFO) of the brain is critical for hypertension development. We recently reported that the brain (pro)renin receptor (PRR) is a novel component of the brain renin-angiotensin system and could be a key initiator of the pathogenesis of hypertension. Here, we examined the expression level and cellular distribution of PRR in the SFO of postmortem human brains to assess its association with the pathogenesis of human hypertension. Postmortem SFO tissues were collected from hypertensive and normotensive human subjects. Immunolabeling for the PRR and a retrospective analysis of clinical data were performed. We found that human PRR was prominently expressed in most neurons and microglia, but not in astrocytes, in the SFO. Importantly, PRR levels in the SFO were elevated in hypertensive subjects. Moreover, PRR immunoreactivity was significantly correlated with systolic blood pressure but not body weight, age, or diastolic blood pressure. Interestingly, this correlation was independent of antihypertensive drug therapy. Our data indicate that PRR in the SFO may be a key molecular player in the pathogenesis of human hypertension and, as such, could be an important focus of efforts to understand the neurogenic origin of hypertension. NEW & NOTEWORTHY This study provides evidence that, in the subfornical organ of the human brain, the (pro)renin receptor is expressed in neurons and microglia cells but not in astrocytes. More importantly, (pro)renin receptor immunoreactivity in the subfornical organ is increased in hypertensive humans and is significantly correlated with systolic blood pressure.

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Section: Introductionmentioning

confidence: 99%

Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans

Cooper

Trivedi

Yamamoto

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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Correlation between Urinary Angiotensinogen (AGT) and Albuminuria in Chronic Kidney Disease (CKD)

Muhammad Ali,

Zhen,

Sadia Hassan

et al. 2024

International Journal of Innovative Science and Research Techno

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Chronic kidney disease (CKD) is a global health concern associated with significant morbidity and mortality. Albuminuria, a hallmark of kidney damage, is a strong predictor of CKD progression and adverse outcomes. Recent research has focused on understanding the correlation between urinary angiotensinogen (AGT) levels, a component of the renin-angiotensin system (RAS), and albuminuria in CKD patients. This review article synthesizes evidence from various studies exploring this correlation and elucidates its mechanistic insights and clinical implications. Clinical studies consistently demonstrate a positive correlation between urinary AGT levels and albuminuria in CKD patients. Elevated urinary AGT levels are associated with increased albuminuria, independent of traditional risk factors, suggesting a potential role for AGT in the pathogenesis of kidney damage and proteinuria in CKD. Mechanistic insights suggest that increased intrarenal RAS activity may lead to enhanced AGT production and secretion, contributing to glomerular hypertension, inflammation, and fibrosis, ultimately promoting albuminuria and CKD progression. The clinical implications of this correlation are profound. Elevated urinary AGT levels may serve as a non-invasive biomarker for assessing intrarenal RAS activity and predicting CKD progression and adverse outcomes. Furthermore, interventions targeting the RAS pathway, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), may help reduce urinary AGT levels and mitigate albuminuria, offering promising therapeutic opportunities for improving patient outcomes in CKD. In conclusion, the correlation between urinary AGT and albuminuria in CKD represents a complex interplay between renal physiology, RAS activation, and kidney damage. By elucidating this correlation, we gain valuable insights into the pathogenesis of CKD and identify urinary AGT as a potential biomarker and therapeutic target for personalized CKD management. Further research is warranted to validate these findings, explore the clinical utility of urinary AGT measurement, and develop targeted interventions aimed at mitigating albuminuria and slowing CKD progression. Through continued investigation, we can strive to improve outcomes and quality of life for patients living with CKD.

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Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH

Cited by 2 publications

References 18 publications

Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans

Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans

Correlation between Urinary Angiotensinogen (AGT) and Albuminuria in Chronic Kidney Disease (CKD)

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