Inappropriate rightward saccades after right hemisphere damage: Oculomotor analysis and anatomical correlates

Bourgeois, Alexia; Chica, Ana B.; Migliaccio, Raffaella; Bayle, Dimitri J.; Duret, Christophe; Pradat‐Diehl, Pascale; Lunven, Marine; Pouget, Pierre; Bartolomeo, Paolo

doi:10.1016/j.neuropsychologia.2015.04.013

Cited by 27 publications

(18 citation statements)

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“…Furthermore, slower response to left as well as right targets with increasing neglect severity (Bartolomeo and Chokron, 1999) and a bilateral shrinkage of the available visual field under increased attentional demands (Russell et al, 2004) have been reported. Also, neglect patients were reported to show inappropriate rightward saccades (Bourgeois et al, 2015) and impaired spatial remapping following exogenous attentional shifts toward the right (Saj et al, 2019). Furthermore, in a detailed study investigating the occurrence of distinct deficit components of visual neglect, subgroups of patients were identified with variable severity combinations of working memory deficits and magnetic attraction of attention and gaze (Toba et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Visual Exploration Area in Neglect: A New Analysis Method for Video-Oculography Data Based on Foveal Vision

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Visual Exploration Area in Neglect: A New Analysis Method for Video-Oculography Data Based on Foveal Vision

et al. 2020

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“…For example, when patients' visual fields are tested by using the confrontation method, as soon as the examiner unfolds his/her arms in the patients' visual fields, patients may immediately lose fixation and shift their gaze towards the right-sided hand, as if ipsilesional stimuli exerted a sort of "magnetic" attraction (MA) on their attention and gaze (Gainotti et al, 1991). More generally, patients tend to produce inappropriate right-directed saccades when they should look at left-sided targets (Bourgeois et al, 2015). Consistent with these observations, patients may show reduced neglect in cancellation tasks when they erase targets rather than drawing over them (Mark, Kooistra, & Heilman, 1988), presumably because removed rightsided targets have no possibility of capturing patients' attention, thus allowing patients to better explore the left portion of the sheet.…”

Section: Introductionmentioning

confidence: 99%

Component deficits of visual neglect: “Magnetic” attraction of attention vs. impaired spatial working memory

Toba

Rabuffetti

Duret³

et al. 2018

Neuropsychologia

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Visual neglect is a disabling consequence of right hemisphere damage, whereby patients fail to detect left-sided objects. Its precise mechanisms are debated, but there is some consensus that distinct component deficits may variously associate and interact in different patients. Here we used a touch-screen based procedure to study two putative component deficits of neglect, rightward "magnetic" attraction of attention and impaired spatial working memory, in a group of 47 right brain-damaged patients, of whom 33 had signs of left neglect. Patients performed a visual search task on three distinct conditions, whereby touched targets could (1) be tagged, (2) disappear or (3) show no change. Magnetic attraction of attention was defined as more left neglect on the tag condition than on the disappear condition, where right-sided disappeared targets could not capture patients' attention. Impaired spatial working memory should instead produce more neglect on the no change condition, where no external cue indicated that a target had already been explored, than on the tag condition. Using a specifically developed analysis algorithm, we identified significant differences of performance between the critical conditions. Neglect patients as a group performed better on the disappear condition than on the no change condition and also better in the tag condition comparing with the no change condition. No difference was found between the tag condition and the disappear condition. Some of our neglect patients had dissociated patterns of performance, with predominant magnetic attraction or impaired spatial working memory. Anatomical results issued from both grey matter analysis and fiber tracking were consistent with the typical patterns of fronto-parietal and occipito-frontal disconnection in neglect, but did not identify lesional patterns specifically associated with one or another deficit, thus suggesting the possible co-localization of attentional and working memory processes in fronto-parietal networks. These findings give support to the hypothesis of the co-occurrence of distinct cognitive deficits in visual neglect and stress the necessity of multi-component models of visuospatial disorders.

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“…While these biases will form the main subject of this article, it is important to note that it may be possible to elicit signs of neglect in patients with no deficit in ocular exploration. For example, in tasks requiring a manual response, it is possible that patients may exhibit a normal pattern of saccadic eye movements, but that they may be impaired in executing a response ( Ladavas et al 1997 ; Bourgeois et al 2015 ). In this article, we consider the control of eye movements, and the conditions that would have to be fulfilled in order to explain the saccadic patterns observed in visual neglect.…”

Section: Introductionmentioning

confidence: 99%

The Computational Anatomy of Visual Neglect

Parr

Friston

2017

Cerebral Cortex

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Visual neglect is a debilitating neuropsychological phenomenon that has many clinical implications and—in cognitive neuroscience—offers an important lesion deficit model. In this article, we describe a computational model of visual neglect based upon active inference. Our objective is to establish a computational and neurophysiological process theory that can be used to disambiguate among the various causes of this important syndrome; namely, a computational neuropsychology of visual neglect. We introduce a Bayes optimal model based upon Markov decision processes that reproduces the visual searches induced by the line cancellation task (used to characterize visual neglect at the bedside). We then consider 3 distinct ways in which the model could be lesioned to reproduce neuropsychological (visual search) deficits. Crucially, these 3 levels of pathology map nicely onto the neuroanatomy of saccadic eye movements and the systems implicated in visual neglect.

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Inappropriate rightward saccades after right hemisphere damage: Oculomotor analysis and anatomical correlates

Cited by 27 publications

References 76 publications

Visual Exploration Area in Neglect: A New Analysis Method for Video-Oculography Data Based on Foveal Vision

Visual Exploration Area in Neglect: A New Analysis Method for Video-Oculography Data Based on Foveal Vision

Component deficits of visual neglect: “Magnetic” attraction of attention vs. impaired spatial working memory

The Computational Anatomy of Visual Neglect

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