Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain)

Zumbado, Manuel; Goethals, M.; Álvarez-León, Eva E.; Luzardo, Octavio P.; Cabrera, F.; Serra-Majem, Lluís; Boada, Luís D.

doi:10.1016/j.scitotenv.2004.07.022

Cited by 134 publications

(76 citation statements)

References 37 publications

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“…In several ways, Canary population seems to have special characteristics: it is a closed population with less exchange of genetic information (2), dietary habits are enriched by fat and carbohydrates (Nutrition Survey of Canary, ENCA. http: //www.gobiernodecanarias.org/sanidad/scs/1/plansalud/ enca/ppal_enca.htm) and there is an inadvertent exposure to persistent pesticides (3). These factors must be related with others, such as genetic factors, to explain the rates of BC in our population.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: A case-control study

Henríquez-Hernández

Murias-Rosales²,

González³

et al. 2009

Oncol Rep

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Abstract. Breast cancer (BC) is a complex disease influenced by environmental and genetic factors. The disease has important genetic and environmental components, most of them are still unknown. An important role of gene polymorphisms related to the risk of developing BC has been reported. However, the results have been controversial. We investigated the association of TSER, MTHFR C677T, p53 codon 72 and MDR1 C3435T gene polymorphisms with breast carcinoma in women from Canary Islands (Spain). Blood samples collected from 135 patients with BC and 304 healthy controls all of them Caucasian, were analyzed through polymerase chain reaction-restriction fragment length polymorphism. Subsequently, a structured questionnaire including patient history and risk factors in relation to BC development was filled out. Allelic frequencies of these genetic variations were: TSER, (2) 0.55 and (3) 0.45 in cases, 0.49 and 0.51 respectively in controls (P=0.240); MTHFR C677T, (C) 0.63 and (T) 0.37 in cases, 0.60 and 0.40 respectively in controls (P=0.568); p53 Arg72Pro, (Arg) 0.74 and (Pro) 0.26 in cases and controls (P=0.910); MDR1 C3435T, (C) 0.52 and (T) 0.48 in cases, 0.55 and 0.45 respectively in controls (P=0.523). We did not observe any gene polymorphism as a risk factor to develop BC. A statistical association was observed between p53 codon 72 polymorphism and family history of breast cancer in both groups, as well as between MDR1 C3435T and smoking habits in cases (P<0.05). Gene polymorphisms vary by regions. The present study contributes to the characterization of the genetic pattern of the Canary population.

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Section: Introductionmentioning

confidence: 99%

Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: A case-control study

Henríquez-Hernández

Murias-Rosales²,

González³

et al. 2009

Oncol Rep

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“…The 682 serum samples of the Spanish population from the Canary Islands was collected in 1998 (Zumbado et al, 2005). The study subjects aged between 6 and 75 years and lived in the Canary Islands, where are extensive farming areas and compose of seven islands.…”

Section: Spainmentioning

confidence: 99%

Organochlorine Pesticides in Human Serum

Kang¹,

Chang²

2011

Pesticides - Strategies for Pesticides Analysis

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“…Thus, in 1960s the mean concentration of DDT in fat tissue from USA population was 5 ppm, while in 1990s this value decreased one hundred times. However, 35 years after the banned of DDT, is possible to measure residues of this product and DDE in serum from different populations (Jakszyn et al, 2009;Zumbado et al, 2005). Organochlorine pesticides can be classified in order to the chemical structure, the manufacture system, and other factors (O'Neil, 2006).…”

Section: Environmentally Persistent Pesticidesmentioning

confidence: 99%

“…Although its use is banned several decades ago, studies have found residues of DDT and its metabolites also in cheese. Again, the relationship between food waste and waste in the population has been established, this time for the case of DDT (Zumbado et al, 2005).…”

Section: The Potentially Hazardous Foods: Milk and Dairy Productsmentioning

confidence: 99%

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

Almeida-González¹,

Boada²,

Zumbado³

et al. 2011

Pesticides - The Impacts of Pesticides Exposure

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Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain)

Cited by 134 publications

References 37 publications

Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: A case-control study

Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: A case-control study

Organochlorine Pesticides in Human Serum

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

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