Inadequate fat diet

Levitsky, А. P.; Egorov, B. V.; Lapinskaya, A. P.; Selivanskaya, I. A.

doi:10.12775/jehs.2020.10.07.029

Cited by 3 publications

(4 citation statements)

References 14 publications

(9 reference statements)

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“…It has been established that excessive consumption of fats causes the activation of free radical oxidation of unsaturated fatty acids with the formation of toxic peroxidation products (Levitsky, Egorov, Lapinskaya et al, 2020).…”

Section: медицинаmentioning

confidence: 99%

Comparative Assessment of the Effect of Consumption of Vegetable Oils With Different Fatty Acid Composition on Lipoperoxidation and the Development of Liver Steatosis

LEVYTSKY,

VELYCHKO,

SELIVANSKA

et al. 2023

Fitoterapia

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Section: медицинаmentioning

confidence: 99%

Comparative Assessment of the Effect of Consumption of Vegetable Oils With Different Fatty Acid Composition on Lipoperoxidation and the Development of Liver Steatosis

LEVYTSKY,

VELYCHKO,

SELIVANSKA

et al. 2023

Fitoterapia

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“…In our previous works [11,12], it was shown that in the composition of lipids of an animal organism in the conditions of keeping animals on a fat-free diet, such fatty acids (for example, PUFA) are also determined, which, as a rule, are not formed in the cells of the body according to the above scheme formation of energy fatty acids [13,[20][21][22].…”

Section: Synthase Fatty Acidsmentioning

confidence: 99%

Effect of dietary fats on endogenous oleic acid biosynthesis in rat liver

Levitsky¹,

Velichko

Selivanskaya³

et al. 2022

J Educ Health Sport

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Aim: Determine the effect of dietary fats with different fatty acid composition on the biosynthesis of oleic acid and its metabolic precursors in the liver . Methods: High linoleic sunflower oil (HLSO), high oleic sunflower oil (HOSO) and palm oil (PO) were used. Rats were fed a semi-synthetic fat-free diet (FFD) and fat diets containing 5 % of the above oils (instead of starch) for 30 days. Liver lipids were divided into 3 fractions: neutral lipids (NL), phospholipids (PL) and free fatty acids (FFA). The fatty acid composition of the fractions was determined by gas chromatography. The “activity” of fatty acid synthase was determined from the total content of the products of this reaction (C16:0 and C16:1). The “activity” of palmitic acid elongase was determined by the ratio С18:0/С16:0, as well as by the formula (С18:0+С18:1)/(С16:0–С16:1). The “activity” of stearic acid desaturase (SCD1) was determined by the ratio C16:1/C16:0 (SCD16) and by the ratio C18:1/C18:0 (SCD18). Results: In rats treated with fat diets, the content of palmitic and oleic acids is reduced only in the NL fraction, and to the greatest extent when consuming the diet with HLSO. The “activity” of palmitic acid elongase increases significantly with the consumption of a diet with HLSO. SCD16 desaturase “activity” decreases with fat diet, while SCD18 desaturase “activity” increases. The level of SCD18 is significantly higher than the level of SCD16. Consumption of HLSO reduces the content of ω-3 PUFA in rat liver lipids, while the intake of HOSO increases it. Conclusions: HLSO diet reduces the endogenous biosynthesis of oleic and palmitic acids, as determined by the analysis of the rat liver NL fraction. A fat diet reduces SCD16 “activity” but increases SCD18 “activity”, especially when fed a diet with HOSO. The diet with HLSO reduces the content of ω-3 PUFA in liver lipids.

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“…First, the presence of two double bonds (С18:2, ω-6) in the linoleic acid molecule determines its instability during storage and thermal cooking due to peroxidation processes [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…And finally, fifthly, linoleic acid in the body is transformed into arachidonic acid (C20:4, ω-6), from which pro-inflammatory eicosanoids are formed [1,3].…”

Section: Introductionmentioning

confidence: 99%

Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil

Levitsky

Pupin

О.

et al. 2022

J Educ Health Sport

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More than 20 % of people over the age of 50 suffer from osteoporosis. Lipids play an important role in the pathogenesis of osteoporosis. Background. To investigate the effect of ordinary (high-linoleic) sunflower oil (OSO) on the state of periodontal bone tissue. Methods. In 5 series of experiments, determine the mineralization activity of the alveolar appendix of the mandible rats that were obtained with feed 5 or 15 percent of OSO for from 22 to 75 days. Mineralizing activity was determined by the ratio of activity of alkaline and acid phosphatase. In liver lipids (fractions of phospholipids and free fatty acids) were determined by the content of long-chain polyunsaturated fatty acids (LCPUFA) by the gas chromatographic method. Results. A decrease in mineralizing activity in OSO consumption, especially when using a feed with 15 % of OSO against a dysbiosis or metabolic syndrome. A significant (almost 10 times) is shown to reduce the content of ω-3 PUFA in fraction of phospholipids of the liver of rats receiving a diet with a content of OSO. Conclusion. Sunflower oil reduces the mineralizing activity of periodontal bone tissue by reducing the endogenous biosynthesis of ω-3 PUFA.

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Inadequate fat diet

Cited by 3 publications

References 14 publications

Comparative Assessment of the Effect of Consumption of Vegetable Oils With Different Fatty Acid Composition on Lipoperoxidation and the Development of Liver Steatosis

Comparative Assessment of the Effect of Consumption of Vegetable Oils With Different Fatty Acid Composition on Lipoperoxidation and the Development of Liver Steatosis

Effect of dietary fats on endogenous oleic acid biosynthesis in rat liver

Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil

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