Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ

Que, Yumei; Shu, Xi; Wang, Langtao; Wang, Sai; Hu, Pengcheng; Tong, Xiaoyong

doi:10.22541/au.159863375.55073751

Cited by 1 publication

(1 citation statement)

References 35 publications

(46 reference statements)

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“…Que et al discovered that pioglitazone activates PPARg and antagonizes the nuclear factor of activated T-lymphocytes (NFAT)/NF-kB, thus decreasing the protein expression of SMC phenotypic modulation markers. Downregulation of these modulation markers prevents cell proliferation, migration, and macrophage adhesion to SMCs, which ameliorates angiotensin II-induced aortic aneurysms (70). The expression of PPARg in bone marrow mesenchymal stem cells of AAA patients was found notably upregulated after the administration of pioglitazone (71).…”

Section: Thiazolidinedionementioning

confidence: 99%

Double-edged sword of diabetes mellitus for abdominal aortic aneurysm

Huang

Zhang

2022

Front. Endocrinol.

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IntroductionDiabetes mellitus (DM) has been proved to contribute to multiple comorbidities that are risk factors for abdominal aortic aneurysm (AAA). Remarkably, evidences from epidemiologic studies have demonstrated a negative association between the two disease states. On the other hand, hyperglycemic state was linked to post-operative morbidities following AAA repair. This review aims to provide a thorough picture on the double-edged nature of DM and major hypoglycemic medications on prevalence, growth rate and rupture of AAA, as well as DM-associated prognosis post AAA repair.MethodsWe performed a comprehensive search in electronic databases to look for literatures demonstrating the association between DM and AAA. The primary focus of the literature search was on the impact of DM on the morbidity, enlargement and rupture rate, as well as post-operative complications of AAA. The role of antidiabetic medications was also explored.ResultsRetrospective epidemiological studies and large database researches associated the presence of DM with decreased prevalence, slower expansion and limited rupture rate of AAA. Major hypoglycemic drugs exert similar protective effect as DM against AAA by targeting pathological hallmarks involved in AAA formation and progression, which were demonstrated predominantly by animal studies. Nevertheless, presence of DM or postoperative hyperglycemia was linked to poorer short-term and long-term prognosis, primarily due to greater risk of infection, longer duration of hospital stays and death.ConclusionWhile DM is a positive factor in the formation and progression of AAA, it is also associated with higher risk of negative outcomes following AAA repair. Concomitant use of antidiabetic medications may contribute to the protective mechanism of DM in AAA, but further studies are still warranted to explore their role following AAA repair.

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Section: Thiazolidinedionementioning

confidence: 99%