Inactivation of Human Kidney Cells by High-Energy Monoenergetic Heavy-Ion Beams

Blakely, Eleanor A.; Tobias, Cornelius A.; Yang, T. C.; Smith, Kendric C.; Lyman, John

doi:10.2307/3575121

Cited by 193 publications

(74 citation statements)

References 44 publications

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“…Dose mean lineal energy density measurements were also variable depending on the counter size and site diameter used. The trend of the data agree with calculations of LET values published in Blakely et al (1979), but large quantitative differences are noted. Additional microdosimetric spectra have been obtained with the 557 MeV/u neon beam by Zaider et al…”

Section: B Depth Modulation: Range Filterssupporting

confidence: 80%

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

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198

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Section: B Depth Modulation: Range Filterssupporting

confidence: 80%

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

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198

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“…about one-tenth that of diagnostic X-ray and 0.4 that of gamma rays from 137 Cs. The main energy transfer was due to heavy ions and alpha particles due to fragment reaction of 12 C (7) , which is consistent with previous knowledge about the specificity of radical production of these particles (11) . Therefore, for detecting higher LET radiation exposure, EPR dosimetry has disadvantages regardless of its having a higher response to neutron exposure (12) .…”

Section: Induced Radioactivitysupporting

confidence: 79%

L Band EPR Tooth Dosimetry for Heavy Ion Irradiation

Yamaguchi

Sato

Kawamura

et al. 2016

Radiat Prot Dosimetry

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Electron Paramagnetic Resonance (EPR) tooth dosimetry is being developed as a device to rapidly assess large populations that were potentially exposed to radiation during a major radiation accident or terrorist event. While most exposures are likely to be due to fallout and therefore involve low linear energy transfer (LET) radiation, there is also a potential for exposures to high LET radiation, for which the effect on teeth has been less well characterized by EPR. Therefore, the aim of this paper is to acquire fundamental response curves for high LET radiation in tooth dosimetry using L band EPR. For this purpose, we exposed human teeth to high energy carbon ions using the heavy ion medical accelerator in Chiba at the National Institute of Radiological Sciences. The primary findings were that EPR signals for carbon ion irradiation were about onetenth the amplitude of the response to the same dose of 150 kVp X-rays.

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“…Brandt and Ritchie [19] have considered an ansatz for the excitation term, D exc (t), as (3) with d = β/2 ω r with ω r = 13 eV for water. In Eq.…”

Section: Model For Radial Electron Spectrummentioning

confidence: 99%

“…The response of physical detectors and biological systems to heavy particle irradiation is of interest in space radiation protection [1,2] and studies of cancer therapy with proton and heavy ion beams [3]. For over 30 years, the average or amorphous track model has successfully described the response of a wide variety of physical detectors and biological systems to heavy particle irradiation using the radial dose distribution from delta-rays about the path of the ion as the key physical descriptor [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Radial distribution of electron spectra from high-energy ions

Cucinotta

Katz

Wilson

1998

Radiation and Environmental Biophysics

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The average track model describes the response of physical and biological systems using radial dose distribution as the key physical descriptor. We report on an extension of this model to describe the average distribution of electron spectra as a function of radial distance from an ion. We present calculations of these spectra for ions of identical linear energy transfer (LET), but dissimilar charge and velocity to evaluate the differences in electron spectra from these ions. To illustrate the usefulness of the radial electron spectra for describing effects that are not described by electron dose, we consider the evaluation of the indirect events in microdosimetric distributions for ions. We show that folding our average electron spectra model with experimentally determined frequency distributions for photons or electrons provides a good representation of radial event spectra from high-energy ions in 0.5-2 µm sites.

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Inactivation of Human Kidney Cells by High-Energy Monoenergetic Heavy-Ion Beams

Cited by 193 publications

References 44 publications

Heavy-Ion Radiobiology: Cellular Studies

Heavy-Ion Radiobiology: Cellular Studies

L Band EPR Tooth Dosimetry for Heavy Ion Irradiation

Radial distribution of electron spectra from high-energy ions

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