In Vivo X-Ray Imaging of Phosphor-Doped PDMS and Phosphor-Doped Aerogel Biomaterials

Allison, S. W.; Baker, Ethan S.; Lynch, Kyle J.; Sabri, Firouzeh

doi:10.1080/00914037.2015.1030652

Cited by 24 publications

(10 citation statements)

References 24 publications

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“…Also, more recently, simple silica-based aerogels has aided the in-vivo tracking of aerogel-based implants in a rat model by using X-ray imaging modalities [58]. In fact, the porous matrix of aerogel has acted as a versatile carrier to encapsulate various amounts of La 2 O 2 S: Eu (0 to 50%) as a thermographic X-ray phosphor dopant.…”

Section: Aerogel For Biomedical Imagingmentioning

confidence: 99%

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

296

192

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Section: Aerogel For Biomedical Imagingmentioning

confidence: 99%

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

296

192

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“…Aerogels are gaining attention as biomaterials because of their low bulk density, high surface area to volume ratio, high mechanical strength and ability to serve as a “host” to therapeutic molecules and cells [ 1 , 2 ]. Recent investigations of polymer-crosslinked silica aerogels (PCSA) have established their biocompatibility and biostability [ 3 , 4 ], the ability to detect them within the body using standard clinical imaging techniques [ 5 , 6 , 7 ], and their capacity to enhance the extension of neurites by PC-12 neural cells and dorsal root ganglia neurons when compared to conventional cell culture substrates [ 8 , 9 , 10 ]. The latter results suggest that crosslinked silica aerogels have the potential to enhance regeneration after nerve injury.…”

Section: Introductionmentioning

confidence: 99%

Growing Neural PC-12 Cell on Crosslinked Silica Aerogels Increases Neurite Extension in the Presence of an Electric Field

Lynch

Skalli

Sabri

2018

JFB

Self Cite

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Externally applied electrical stimulation (ES) has been shown to enhance the nerve regeneration process and to influence the directionality of neurite outgrowth. In addition, the physical and chemical properties of the substrate used for nerve-cell regeneration is critical in fostering regeneration. Previously, we have shown that polyurea-crosslinked silica aerogels (PCSA) exert a positive influence on the extension of neurites by PC-12 cells, a cell-line model widely used to study neurite extension and electrical excitability. In this work, we have examined how an externally applied electric field (EF) influences the extension of neurites in PC-12 cells grown on two substrates: collagen-coated dishes versus collagen-coated crosslinked silica aerogels. The externally applied direct current (DC) bias was applied in vitro using a custom-designed chamber containing polydimethysiloxane (PDMS) embedded copper electrodes to create an electric field across the substrate for the cultured PC-12 cells. Results suggest orientation preference towards the anode, and, on average, longer neurites in the presence of the applied DC bias than with 0 V DC bias. In addition, neurite length was increased in cells grown on silica-crosslinked aerogel when compared to cells grown on regular petri-dishes. These results further support the notion that PCSA is a promising material for nerve regeneration.

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“…This material is scalable to large flexible substrates [ 38 ] due to its liquid phase, low-temperature, and low-cost deposition techniques. In addition, PDMS is a flexible and environmentally friendly polymer with tunable chemical, physical, and electrical properties and it is usually used in biomedical and in vivo applications [ 39 , 40 ]. There are also active layers of some electronic devices that use a combination of nanomaterials and PDMS.…”

Section: Introductionmentioning

confidence: 99%

A High-Sensitivity Flexible Direct X-ray Detector Based on Bi2O3/PDMS Nanocomposite Thin Film

Mao

Chen

et al. 2021

Nanomaterials

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The characteristics of mechanical flexibility, low health risk, and simple processing of polymer nanocomposite materials make them potentially applicable as flexible X-ray detectors. In this study, we report on a high sensitivity, environmentally friendly, and flexible direct X-ray detector using polymer nanocomposite material consisting of bismuth oxide (Bi2O3) nanoparticles and polydimethylsiloxane (PDMS). This detector was realized by printing patterned Ag electrodes on the polymer nanocomposite material. The response of PDMS to X-rays was verified for the first time, and the effect of doping different contents of Bi2O3 nanoparticles on the performance of the device was tested. The optoelectronic performance of the optimized detector indicated a high sensitivity (203.58 μC Gyair−1 cm−2) to low dose rate (23.90 μGyair s−1) at a 150 V bias voltage and the X-ray current density (JX-ray) was 10,000-fold higher than the dark current density (Jdark). The flexible direct X-ray detector could be curled for 10,000 cycles with slight performance degradation. The device exhibited outstanding stability after storage for over one month in air. Finally, this device provides new guidance for the design of high-performance flexible direct X-ray detectors.

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In Vivo X-Ray Imaging of Phosphor-Doped PDMS and Phosphor-Doped Aerogel Biomaterials

Cited by 24 publications

References 24 publications

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Growing Neural PC-12 Cell on Crosslinked Silica Aerogels Increases Neurite Extension in the Presence of an Electric Field

A High-Sensitivity Flexible Direct X-ray Detector Based on Bi2O3/PDMS Nanocomposite Thin Film

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