In-vivo waveguide cardiac magnetic resonance elastography

Mazumder, Ria; Clymer, Bradley D.; White, Richard D.; Romano, Anthony J.; Kolipaka, Arunark

doi:10.1186/1532-429x-17-s1-p35

Cited by 8 publications

(5 citation statements)

References 2 publications

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“…In addition, although attempts were made to ensure image quality was consistent and above a certain threshold using an OSS-SNR metric, SNR variations between participants could still have an impact on stiffness estimates. In future studies, it may be beneficial to account for anisotropy ( 5 , 37 ) to obtain the full stiffness tensor ( 38 ), improve inversion algorithms to make them more robust to noise, and potentially improve the effectiveness of the curl operator for stiffness calculation ( 39 , 40 ). Second, a 5-mm isotropic acquisition resolution was used, which provided suboptimal spatial resolution and limited interrogation of tissue waves across the myocardium but was necessary to ensure high SNR and good shear wave detectability.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography

Arani,

Murphy,

Bhopalwala

et al. 2024

Radiology: Cardiothoracic Imaging

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Purpose To investigate the feasibility of using quantitative MR elastography (MRE) to characterize the influence of aging and sex on left ventricular (LV) shear stiffness. Materials and Methods In this prospective study, LV myocardial shear stiffness was measured in 109 healthy volunteers (age range: 18–84 years; mean age, 40 years ± 18 [SD]; 57 women, 52 men) enrolled between November 2018 and September 2019, using a 5-minute MRE acquisition added to a clinical MRI protocol. Linear regression models were used to estimate the association of cardiac MRI and MRE characteristics with age and sex; models were also fit to assess potential age-sex interaction. Results Myocardial shear stiffness significantly increased with age in female (age slope = 0.03 kPa/year ± 0.01, P = .009) but not male (age slope = 0.008 kPa/year ± 0.009, P = .38) volunteers. LV ejection fraction (LVEF) increased significantly with age in female volunteers (0.23% ± 0.08 per year, P = .005). LV end-systolic volume (LVESV) decreased with age in female volunteers (−0.20 mL/m 2 ± 0.07, P = .003). MRI parameters, including T1, strain, and LV mass, did not demonstrate this interaction ( P > .05). Myocardial shear stiffness was not significantly correlated with LVEF, LV stroke volume, body mass index, or any MRI strain metrics ( P > .05) but showed significant correlations with LV end-diastolic volume/body surface area (BSA) (slope = −3 kPa/mL/m 2 ± 1, P = .004, r 2 = 0.08) and LVESV/BSA (−1.6 kPa/mL/m 2 ± 0.5, P = .003, r 2 = 0.08). Conclusion This study demonstrates that female, but not male, individuals experience disproportionate LV stiffening with natural aging, and these changes can be noninvasively measured with MRE. Keywords: Cardiac, Elastography, Biological Effects, Experimental Investigations, Sexual Dimorphisms, MR Elastography, Myocardial Shear Stiffness, Quantitative Stiffness Imaging, Aging Heart, Myocardial Biomechanics, Cardiac MRE Supplemental material is available for this article . Published under a CC BY 4.0 license.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography

Arani,

Murphy,

Bhopalwala

et al. 2024

Radiology: Cardiothoracic Imaging

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“…Romano et al and Mazumder et al used waveguide MRE to assess the anisotropic stiffness of myocardium 94,95 . Mazumder et al demonstrated the anisotropy of the myocardium, indicating higher stiffness coefficients in systole compared to diastole and that longitudinal coefficients have significantly higher stiffness compared to shear stiffness coefficients 95 . In the future, estimating anisotropic stiffness of the myocardium might play an important role in diagnosing and developing different therapeutic agents for treating systolic- and diastolic dysfunction-based diseases.…”

Section: Future Mre Applicationsmentioning

confidence: 99%

Advances and Future Direction of Magnetic Resonance Elastography

Dong

White

Kolipaka

2018

Topics in Magnetic Resonance Imaging

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The mechanical properties of soft tissues are closely associated with a variety of diseases. This motivates the development of elastography techniques in which tissue mechanical properties are quantitatively estimated through imaging. Magnetic resonance elastography (MRE) is a non-invasive phase-contrast MR technique where shear modulus of soft tissue can be spatially and temporally estimated. MRE has recently received significant attention due to its capability in non-invasively estimating tissue mechanical properties, which can offer considerable diagnostic potential. In this work, recent technology advances of MRE, its future clinical applications, and the related limitations will be discussed.

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“…However, all the measurements are assumed to be isotropic and termed ‘effective’ as they do not consider anisotropy or the complex geometry of the heart. Mazumder et al developed wave‐guide CMRE, in which diffusion tensor imaging (DTI) is performed in conjunction with CMRE at the same spatial resolution to estimate the anisotropic stiffness of the myocardium. DTI is performed to obtain the fiber orientation.…”

Section: Applications Of Cardiovascular Mrementioning

confidence: 99%

Cardiovascular magnetic resonance elastography: A review

2017

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Cardiovascular diseases are the leading cause of death worldwide. These cardiovascular diseases are associated with mechanical changes in the myocardium and aorta. It is known that stiffness is altered in many diseases, including the spectrum of ischemia, diastolic dysfunction, hypertension and hypertrophic cardiomyopathy. In addition, the stiffness of the aortic wall is altered in multiple diseases, including hypertension, coronary artery disease and aortic aneurysm formation. For example, in diastolic dysfunction in which the ejection fraction is preserved, stiffness can potentially be an important biomarker. Similarly, in aortic aneurysms, stiffness can provide valuable information with regard to rupture potential. A number of studies have addressed invasive and non-invasive approaches to test and measure the mechanical properties of the myocardium and aorta. One of the non-invasive approaches is magnetic resonance elastography (MRE). MRE is a phase-contrast magnetic resonance imaging technique that measures tissue stiffness non-invasively. This review article highlights the technical details and application of MRE in the quantification of myocardial and aortic stiffness in different disease states.

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In-vivo waveguide cardiac magnetic resonance elastography

Cited by 8 publications

References 2 publications

Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography

Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography

Advances and Future Direction of Magnetic Resonance Elastography

Cardiovascular magnetic resonance elastography: A review

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