Advances and Future Direction of Magnetic Resonance Elastography

Dong, Haitao; White, Richard D.; Kolipaka, Arunark

doi:10.1097/rmr.0000000000000179

Cited by 10 publications

(15 citation statements)

References 114 publications

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“…Phase-contrast Magnetic Resonance Imaging (PC-MRI) is a well-established method for measuring flow velocities [1,2,3] or tissue displacements due to harmonic excitation as used in Magnetic Resonance Elastography (MRE) [4,5,6,7,8,9,10]. MRE is used for the non-invasive characterization of the mechanical properties of a specific tissue or organ of interest and has been used for many different applications in pre-clinical animal [11,12,13] and in vivo human studies (e.g.…”

Section: Introductionmentioning

confidence: 99%

Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging

Herthum

Carrillo

Osses

et al. 2022

Medical Image Analysis

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Section: Introductionmentioning

confidence: 99%

Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging

Herthum

Carrillo

Osses

et al. 2022

Medical Image Analysis

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“…4 These encouraging results and the versatility of MRE have stimulated considerable research advancing this novel technique towards more clinical applications. 5 To date, MRE has been used to measure the stiffness in various organs, including the brain, [6][7][8] breast, 9,10 skeletal muscle, 11,12 heart, 13,14 kidney 15 and lung. 16,17 Aortic stiffness is known to be closely associated with a variety of cardiovascular comorbidities, such as systemic arterial hypertension 18 and abdominal aortic aneurysm (AAA).…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, MRE‐derived hepatic stiffness has excellent diagnostic accuracy in grading liver fibrosis 4 . These encouraging results and the versatility of MRE have stimulated considerable research advancing this novel technique towards more clinical applications 5 . To date, MRE has been used to measure the stiffness in various organs, including the brain, 6–8 breast, 9,10 skeletal muscle, 11,12 heart, 13,14 kidney 15 and lung.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance elastography for estimating in vivo stiffness of the abdominal aorta using cardiac‐gated spin‐echo echo‐planar imaging: a feasibility study

et al. 2020

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Introduction: Magnetic resonance elastography (MRE)-derived aortic stiffness is a potential biomarker for multiple cardiovascular diseases. Currently, gradient-recalled echo (GRE) MRE is a widely accepted technique to estimate aortic stiffness. However, multi-slice GRE MRE requires multiple breath-holds (BHs), which can be challenging for patients who cannot consistently hold their breath. The aim of this study was to investigate the feasibility of a multi-slice spin-echo echo-planar imaging (SE-EPI) MRE sequence for quantifying in vivo aortic stiffness using a free-breathing (FB) protocol and a single-BH protocol. Method: On Scanner 1, 25 healthy subjects participated in the validation of FB SE-EPI against FB GRE. On Scanner 2, another 15 healthy subjects were recruited to compare FB SE-EPI with single-BH SE-EPI. Among all volunteers, five participants were studied on both scanners to investigate the inter-scanner reproducibility of FB SE-EPI aortic MRE. Bland-Altman analysis, Lin's concordance correlation coefficient (LCCC) and coefficient of variation (COV) were evaluated. The phase-difference signal-to-noise ratios (PD SNR) were compared. Results: Aortic MRE using FB SE-EPI and FB GRE yielded similar stiffnesses (paired t-test, P = 0.19), with LCCC = 0.97. The FB SE-EPI measurements were reproducible (intra-scanner LCCC = 0.96) and highly repeatable (LCCC = 0.99). The FB SE-EPI MRE was also reproducible across different scanners (inter-scanner LCCC = 0.96). Single-BH SE-EPI scans yielded similar stiffness to FB SE-EPI scans (LCCC = 0.99) and demonstrated a low COV of 2.67% across five repeated measurements. Conclusion: Multi-slice SE-EPI aortic MRE using an FB protocol or a single-BH protocol is reproducible and repeatable with advantage over multi-slice FB GRE in reducing acquisition time. Additionally, FB SE-EPI MRE provides a potential alternative to BH scans for patients who have challenges in holding their breath.

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“…First, the resolution of the temporally resolved scan can be increased further. Although the resolution used in the experiments here are fast relative to typical MRI scans, a 5–10‐fold improvement is necessary to image shear waves on the same frequencies used in conventional MRE and ultrasound elastography methods 1–3,10,33 . Currently, the resolution is 14 ms in the phantom scans and 22 ms in the in vivo scans, whereas cardiac MRE typically uses frequencies exceeding 100 Hz that require a resolution of 5 ms or better to image the waves.…”

Section: Discussionmentioning

confidence: 99%

Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves

Nguyen

Bonner

Foster

et al. 2022

Magnetic Resonance in Med

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Purpose The noninvasive measurement of biological tissue elasticity is an evolving technology that enables the robust characterization of soft tissue mechanics for a wide array of biomedical engineering and clinical applications. We propose, design, and implement here a new MRI technique termed asynchronous magnetic resonance elastography (aMRE) that pushes the measurement technology toward a driverless implementation. This technique can be added to clinical MRI scanners without any additional specialized hardware. Theory Asynchronous MRE is founded on the theory of diffuse wavefields and noise correlation previously developed in ultrasound to reconstruct shear wave speeds using seemingly incoherent wavefields. Unlike conventional elastography methods that solve an inverse problem, aMRE directly reconstructs a pixel‐wise mapping of wave speed using the spatial–temporal statistics of the measured wavefield. Methods Incoherent finger tapping served as the wave‐generating source for all aMRE measurements. Asynchronous MRE was performed on a phantom using a Siemens Prismafit as an experimental validation of the theory. It was further performed on thigh muscles as a proof‐of‐concept implementation of in vivo imaging using a Siemens Skyra scanner. Results Numerical and phantom experiments show an accurate reconstruction of wave speeds from seemingly noisy wavefields. The proof‐of‐concept thigh experiments also show that the aMRE protocol can reconstruct a pixel‐wise mapping of wave speeds. Conclusion Asynchronous MRE is shown to accurately reconstruct shear wave speeds in phantom experiments and remains at the proof‐of‐concept stage for in vivo imaging. After further validation and improvements, it has the potential to lower both the technical and monetary barriers of entry to measuring tissue elasticity.

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Advances and Future Direction of Magnetic Resonance Elastography

Cited by 10 publications

References 114 publications

Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging

Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging

Magnetic resonance elastography for estimating in vivo stiffness of the abdominal aorta using cardiac‐gated spin‐echo echo‐planar imaging: a feasibility study

Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves

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