In vivo transthoracic measurements of acoustic radiation force induced displacements in the heart over the cardiac cycle

Kakkad, Vaibhav; Kuo, Lily; Bradway, David; Trahey, Gregg E.; Sivak, Joseph; Kisslo, Joseph

doi:10.1109/ultsym.2015.0155

Cited by 3 publications

(7 citation statements)

References 14 publications

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“…These results are consistent with the result of our previous publication regarding the linear relationship between ARFI and SWEI measurements . Because of technical limitations, ARFI might be the first cardiac stiffness measurement technique to become practical transthoracically …”

Section: Discussionsupporting

confidence: 92%

“…It has been shown that shear wave measurements can be recorded transthoracically in human and porcine models . A number of researchers have reported feasibility of ARFI measurement transthoracically during the cardiac cycle in clinical subjects . Moreover, transthoracic SWEI measurements have been demonstrated in the clinic .…”

Section: Discussionmentioning

confidence: 99%

“…19 Because of technical limitations, ARFI might be the first cardiac stiffness measurement technique to become practical transthoracically. 20 There has been an effort in the field to correlate the IVP and the intramyocardial pressure. A review paper by Westerhof shows that the relationship between these two is poor.…”

Section: Discussionmentioning

confidence: 99%

“…24,25 A number of researchers have reported feasibility of ARFI measurement transthoracically during the cardiac cycle in clinical subjects. 20,26 Moreover, transthoracic SWEI measurements have been demonstrated in the clinic. 24,27 While the feasibility of these measurements is shown, understanding the physiologic meaning of these measurements and their clinical value needs to be studied and that is the major goal of this paper.…”

Section: Vejdani-jahromi Et Al-intraventricular Pressure By Ultrasounmentioning

confidence: 99%

See 3 more Smart Citations

Measuring Intraventricular Pressure Using Ultrasound Elastography

Vejdani‐Jahromi

Freedman

Trahey

et al. 2018

J of Ultrasound Medicine

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Vejdani-jahromi Et Al-intraventricular Pressure By Ultrasounmentioning

confidence: 99%

See 2 more Smart Citations

Measuring Intraventricular Pressure Using Ultrasound Elastography

Vejdani‐Jahromi

Freedman

Trahey

et al. 2018

J of Ultrasound Medicine

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“…Background tissue motion was suppressed by applying a 3 rd -order high-pass Butterworth filter with a cutoff frequency of 75 Hz through time (Kakkad et al, 2015). The filter was applied in the forward and reverse directions to minimize phase distortions.…”

Section: Data Processingmentioning

confidence: 99%

Non-invasive Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force Impulse Imaging

Kakkad

LeFevre

Hollender

et al. 2019

Ultrasound in Medicine & Biology

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Myocardial stiffness exhibits cyclic variations over the course of the cardiac cycle. These trends are closely tied to the electro-mechanical and hemodynamic changes in the heart. Characterization of dynamic myocardial stiffness can provide insights into the functional state of the myocardium as well as allow for differentiation between the underlying physiological mechanisms that lead to congestive heart failure. Previous work has demonstrated the potential of acoustic radiation force impulse (ARFI) imaging to capture temporal trends of myocardial stiffness in experimental preparations such as the Langendorff heart as well as on animals in open-chest and intracardiac settings. This study aims to investigate the potential of ARFI to measure dynamic myocardial stiffness on human subjects, in a noninvasive manner through transthoracic imaging windows. ARFI imaging was performed on twelve healthy volunteers to track stiffness changes within the interventricular septum (IVS) in the parasternal long-axis (PLAX) and short-axis (PSAX) views. Myocardial stiffness dynamics over the cardiac cycle were quantified using five indices: stiffness ratio, rates of relaxation and contraction, and time constants of relaxation and contraction. Yield of ARFI acquisitions was evaluated based on metrics of signal strength and tracking fidelity such as displacement signal-to-noise, signal-to-clutter level, temporal coherence of speckle, and spatial similarity within the region-of-excitation (ROE). These were quantified using the mean ARFinduced displacements over the cardiac cycle, the contrast between the myocardium and the cardiac chambers, the minimum correlation coefficients of RF signals, and the correlation between displacement traces across simultaneously-acquired azimuthal beams, respectively.

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Assessment of Diastolic Function Using Ultrasound Elastography

Vejdani‐Jahromi

Freedman

Kim

et al. 2018

Ultrasound in Medicine & Biology

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Shear wave elasticity imaging (SWEI) is a novel ultrasound elastography technique for assessing tissue stiffness. In this study, we investigate the potential of SWEI for providing diastolic functional assessment. In 11 isolated rabbit hearts, pressure-volume (PV) measurements were recorded simultaneously with SWEI recordings from the left ventricle free wall before and after induction of global ischemia. PV-based end diastolic stiffness increased by 100% after ischemia (p <0.05), and SWEI stiffness showed an increase of 103% (p <0.05). The relaxation time constant (τ) before and after ischemia derived from pressure and SWEI curves showed increases of 79% and 76%, respectively (p <0.05). A linear regression between pressure-derived and SWEI-based (τ) showed a slope of 1.164 with R = 0.80, indicating the near equivalence of the two assessments. SWEI can be used to derive (τ) values and myocardial end diastolic stiffness. In global conditions, these measurements are consistent with PV measurements of diastolic function.

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In vivo transthoracic measurements of acoustic radiation force induced displacements in the heart over the cardiac cycle

Cited by 3 publications

References 14 publications

Measuring Intraventricular Pressure Using Ultrasound Elastography

Measuring Intraventricular Pressure Using Ultrasound Elastography

Non-invasive Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force Impulse Imaging

Assessment of Diastolic Function Using Ultrasound Elastography

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