In vivo tissue response to resorbable silica xerogels as controlled-release materials

Radin, S.; El‐Bassyouni, Gehan T.; Vresilovic, Edward J.; Schepers, Evert; Ducheyne, Paul

doi:10.1016/j.biomaterials.2004.04.004

Cited by 206 publications

(139 citation statements)

References 30 publications

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“…The agents are embedded in the matrix of the gel, which after condensation and drying becomes a porous, glassy solid [2,3,[9][10][11][12][13]. Data show that controlled release of antibiotics, proteins, and growth factors is possible from this porous material [2,[9][10][11][12][13]. These studies also demonstrate that the release is dependent on synthesis parameters such as the molar ratio of silica precursor to water, type of precursor and the concentration of bioactive drugs [2,10,11].…”

Section: Q3mentioning

confidence: 99%

“…Due to the mild processing conditions, high concentrations of many types of biologically active agents can be incorporated in the liquid sol. The agents are embedded in the matrix of the gel, which after condensation and drying becomes a porous, glassy solid [2,3,[9][10][11][12][13]. Data show that controlled release of antibiotics, proteins, and growth factors is possible from this porous material [2,[9][10][11][12][13].…”

Section: Q3mentioning

confidence: 99%

“…Room temperature processed, silica based sol gels are resorbable materials with a favorable tissue response [2,9]. They have been studied for biomedical applications that include tissue, cell and enzyme encapsulation and controlled release of drugs [2,3,[6][7][8][9][10][11][12][13].…”

Section: Q3mentioning

confidence: 99%

“…They have been studied for biomedical applications that include tissue, cell and enzyme encapsulation and controlled release of drugs [2,3,[6][7][8][9][10][11][12][13]. Derived from a metal alkoxide precursor, the sol is produced through a hydrolysis and polycondensation reaction [14].…”

Section: Q3mentioning

confidence: 99%

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The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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Controlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspheres were remarkably different from those of sol gel granules produced by grinding and sieving. In contrast to a fast, short-term release from granules, the release from microspheres was slower and of longer duration. In addition, the degradation rate of microspheres was significantly slower than that of the granules. Using various mathematical models, the data reveal that the release from sol gel powder is governed by two distinct phases of release. In addition, the release from emulsified microspheres is delayed, a finding that can be attributed to differences in surface properties of the particles produced by emulsification and those produced by casting and grinding. The presented results represent an excellent data set for designing and implementing preclinical studies. t r a c tControlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspher...

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Section: Q3mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

Section: Q3mentioning

confidence: 99%

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The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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“…The silica sol-gel composites are novel controlled-release materials that are resorbable and biocompatible. 49 Thin sol-gel films coating vancomycin on a Ti-alloy substrate were synthesized for the prevention and treatment of bone infections. The vancomycin-containing sol-gel film decreased profoundly the number of Staphylococcus aureus when evaluated in a rat osteomyelitis model.…”

Section: Coating Materialsmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Nanocomposites for Tissue Engineering

Gelinsky

Heinemann

2010

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Requirements for Successful Tissue Engineering Composites and Nanocomposites Composites Nanocomposites Hybrids Biological Nanocomposites Bone Biological Nanocomposites as Scaffolds Organic–Organic Nanocomposites Inorganic–Inorganic Nanocomposites Organic–Inorganic Composites Mineralized Collagen: Nanocomposites that Mimic the ECM of Bone Silica‐Based Nanocomposites for Tissue Engineering Organic–Inorganic Nanocomposites Containing Fibers Nanocomposites Containing Carbon Nanotubes ( CNTs ) Summary and Outlook

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In vivo tissue response to resorbable silica xerogels as controlled-release materials

Cited by 206 publications

References 30 publications

The controlled release of drugs from emulsified, sol gel processed silica microspheres

The controlled release of drugs from emulsified, sol gel processed silica microspheres

Recent advances in materials for extended-release antibiotic delivery system

Nanocomposites for Tissue Engineering

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