In Vivo Testing of a Completely Implanted Total Artificial Heart System

Aj, Snyder; Rosenberg, G; Wj, Weiss; Sk, Ford; Ra, Nazarian; Dl, Hicks; Ja, Marlotte; Kawaguchi, Osamu; Ga, Prophet; Js, Sapirstein

doi:10.1097/00002480-199307000-00006

Cited by 7 publications

(3 citation statements)

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“…A completely implantable version of the 70cc LVAD, dubbed the “LionHeart,” has since been developed. This device removed the external leads present in the pneumatic device and relied on an electrically driven pusher plate to achieve the compression [2, 3]. The 70 cc device was designed by in vitro and in vivo techniques without using computational fluid dynamics (CFD).…”

Section: Introductionmentioning

confidence: 99%

Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data

Medvitz

Reddy

Deutsch

et al. 2009

Journal of Biomechanical Engineering

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Computational fluid dynamics (CFD) is used to asses the hydrodynamic performance of a positive displacement left ventricular assist device. The computational model uses implicit large eddy simulation direct resolution of the chamber compression and modeled valve closure to reproduce the in vitro results. The computations are validated through comparisons with experimental particle image velocimetry (PIV) data. Qualitative comparisons of flow patterns, velocity fields, and wall-shear rates demonstrate a high level of agreement between the computations and experiments. Quantitatively, the PIV and CFD show similar probed velocity histories, closely matching jet velocities and comparable wall-strain rates. Overall, it has been shown that CFD can provide detailed flow field and wall-strain rate data, which is important in evaluating blood pump performance.

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Section: Introductionmentioning

confidence: 99%

Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data

Medvitz

Reddy

Deutsch

et al. 2009

Journal of Biomechanical Engineering

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“…For example, the Arrow International LionHeart and Abiomed’s AbioCor cardiac assist devices utilized PUU elastomers in the blood pump. 11 Our group at Penn State has investigated ventricular assist systems including implantable left ventricular assist devices 12 and total artificial hearts 13 for adults and a pediatric ventricular assist device for infants 14 for many decades. The PUU material Biospan MS/0.4 (former Polymer Technology Group, now DSM Biomedical Inc. Exton, PA) was used in parts of these devices such as blood sacs and catheters due its high durability and low degradation during long term performance.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers

Nguyen

Yeager

et al. 2023

J Biomater Appl

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Segmented polyurethane (PU) block copolymers are widely used in implantable cardiovascular medical devices due to their good biocompatibility and excellent mechanical properties. More specifically, PU Biospan MS/0.4 was used in ventricular assist devices over the past decades. However, this product is being discontinued and it has become necessary to find an alternative PU biomaterial for application in cardiovascular devices. One important criterion for assessing cardiac biomaterials is blood compatibility. In this study, we characterized the surface properties of four medical-grade PU biomaterials: Biospan MS/0.4, BioSpan S, BioSpan 2F, and CarboSil 20 80A, including surface chemistry, topography, microphase separation structure and wettability, and then measured the blood plasma coagulation responses using bovine and human blood plasma. Results showed that BioSpan 2F contains high amounts of fluorine and has the lowest surface free energy while the other materials have surfaces with silicone present. An in vitro coagulation assay shows that these materials demonstrated improved blood coagulation responses compared to the polystyrene control and there were no significant differences in coagulation time among all PU biomaterials. The chromogenic assay showed all PU materials led to low FXII contact activation, and there were no significant differences in FXII contact activation, consistent with plasma coagulation responses.

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“…Recent efforts in TAH development, therefore, have been directed toward a totally implantable system which can reduce the chance of infection and provide patients with an acceptable quality of life by eliminating an external tether. Considerable progress has been made in developing such a system during the last decade, especially in the United States where it is being accelerated by NIH sponsored contracts, with chronic animal survivors for over 5 months ( 1, 2). Nevertheless, all the systems under development in the United States seem too bulky to be implanted into the pericardial space of oriental patients of standard physique.…”

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confidence: 99%

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

et al. 1999

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We have been developing an electrohydraulic total artificial heart system. The system comprises an intrathoracic pumping unit composed of diaphragm type ellipsoidal blood pumps and an energy converter in addition to an electronics unit. The in vivo performance of the pumping unit was evaluated in a series of animal implantations with 3 calves weighing 62-85 kg. An interatrial shunt 4.5 mm in diameter was made in the atrial septum to compensate left-right imbalance. Two calves died early postoperatively, one of external controller power failure and the other of interatrial shunt stenosis due to thrombus formation. One calf, however, survived over 10 days under stable circulatory conditions. No abnormality was found in the oxygen metabolic condition or in major organ functions. The generation and dissipation of heat from the device was acceptable. This animal died of device malfunction caused by energy converter bearing breakdown. The device demonstrated a good anatomic fit without compromising the great vessels and adjacent tissues. It is concluded that the pumping unit has a sufficient in vivo basic performance although appropriate countermeasures are to be implemented against the detected problems concerning mechanical durability and interatrial shunt patency.

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In Vivo Testing of a Completely Implanted Total Artificial Heart System

Cited by 7 publications

References 0 publications

Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data

Validation of a CFD Methodology for Positive Displacement LVAD Analysis Using PIV Data

In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

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