In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters

Lai, Lanmei; Zhao, Chunqiu; Su, Meina; Li, Xiaoqi; Liu, Xiaoli; Jiang, Hui; Amatore, Christian; Wang, Xuemei

doi:10.1039/c6bm00233a

Cited by 44 publications

(32 citation statements)

References 41 publications

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“…Energy management, textiles, batteries, health care, catalysis, cosmetics, semiconductors, and chemical sensing are only a few of the applications for (Cu and Ni) NPs [16][17][18]. These metallic NPs are non-toxic, biocompatible, and have a wide range of medicinal uses, including anti-cancer [19], anti-inflammation [20], antimicrobial selective drug delivery [21], wound healing, and bio-imaging [22,23].…”

Section: Introductionmentioning

confidence: 99%

Curcuma longa Mediated Synthesis of Copper Oxide, Nickel Oxide and Cu-Ni Bimetallic Hybrid Nanoparticles: Characterization and Evaluation for Antimicrobial, Anti-Parasitic and Cytotoxic Potentials

et al. 2021

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Nanoparticles have long been known and their biomedical potent activities have proven that these can provide an alternative to other drugs. In the current study, copper oxide, nickel oxide and copper/nickel hybrid NPs were biosynthesized by using Curcuma longa root extracts as a reducing and capping agent, followed by characterization via UV-spectroscopy, Fourier transformed infrared spectroscopy (FTIR), energy dispersive X-ray (EDX), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo galvanometric analysis (TGA), and band gap. FTIR spectroscopy shows the availability of various functional groups and biomolecules such as carbohydrate, protein, polysaccharides, etc. The EDX peak confirmed that the elemental nickel and copper were present in large quantity in the analyzed sample. Scanning electron micrographs showed that the synthesized CuO-NPs and NiO-NPs were polyhedral uniform and homogeneous in morphology, while the copper/nickel hybrid NPs were well dispersed, spherical in shape, and uniform in size. TEM micrographs of CuO-NPs had 27.72 nm, NiO had 23.13 nm and, for their hybrid, the size was 17.38 nm, which was confirmed respectively. The CuO and NiO NPs possessed spherical- to multi-headed shapes, while their hybrid showed a complete spherical shape, small size, and polydispersed NPs. The XRD spectra revealed that the average particle size for CuO, NiO, and hybrid were 29.7 nm, 28 nm and 27 nm, respectively. Maximum anti-diabetic inhibition of (52.35 ± 0.76: CuO-NPs, 68.1 ± 0.93: NiO-NPs and 74.23 ± 0.42: Cu + Ni hybrids) for α-amylase and (39.25 ± 0.18 CuO-NPs, 52.35 ± 1.32: NiO-NPs and 62.32 ± 0.48: Cu + Ni hybrids) for α-glucosidase were calculated, respectively, at 400 µg/mL. The maximum antioxidants capacity was observed as 65.1 ± 0.83 μgAAE/mg for Cu-Ni hybrids, 58.39 ± 0.62 μgAAE/mg for NiO-NPs, and 52.2 ± 0.31 μgAAE/mg for CuO-NPs, respectively, at 400 μg/mL. The highest antibacterial activity of biosynthesized NPs was observed against P. aeuroginosa (28 ± 1.22) and P. vulgaris (25 ± 1.73) for Cu + Ni hybrids, respectively. Furthermore, the antibiotics were coated with NPs, and activity was noted. Significant anti-leishmanial activity of 60.5 ± 0.53 and 68.4 ± 0.59 for Cu + Ni hybrids; 53.2 ± 0.48 and 61.2 ± 0.44 for NiO-NPs; 49.1 ± 0.39 and 56.2 ± 0.45 for CuO-NPs at 400 μg/mL were recorded for promastigote and amastigotes, respectively. The biosynthesized NPs also showed significant anti-cancerous potential against HepG2 cell lines. It was concluded from the study that NPs are potential agents to be used as an alternative to antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Curcuma longa Mediated Synthesis of Copper Oxide, Nickel Oxide and Cu-Ni Bimetallic Hybrid Nanoparticles: Characterization and Evaluation for Antimicrobial, Anti-Parasitic and Cytotoxic Potentials

et al. 2021

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“…Zn-based ceramic materials, including zinc oxide (ZnO), zinc sulphide (ZnS), zinc selenide (ZnSe), zinc phosphate (Zn 3 (PO 4 ) 2 ), and zinc aluminate (ZnAl 2 O 4 ), have been extensively explored in a variety of biomedical applications [7,56]. The major methods, characteristics, and biomedical applications of Zn based ceramic biomaterials are summarized (Table 1) and discussed in the following sections [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75].…”

Section: Zinc-based Ceramic Biomaterialsmentioning

confidence: 99%

Zinc-Based Biomaterials for Regeneration and Therapy

Cockerill

Wang

et al. 2019

Trends in Biotechnology

280

181

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Zinc has been described as the "calcium of the twenty-first century." Zinc-based degradable biomaterials have recently emerged thanks to their intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. Zinc-based biomaterials mainly include metallic zinc alloys, zinc ceramic nanomaterials, and zinc metal-organic frameworks (MOFs). Metallic zinc implants degrade at a desirable rate, matching the healing pace of local tissues, and stimulating remodeling and formation of new tissues. Zinc ceramic nanomaterials are also beneficial for tissue engineering and therapy thanks to their nanostructures and antibacterial properties. MOFs have large surface areas and are easily functionalized, making them ideal for drug delivery and cancer therapy. This review highlights recent developments in zinc-based biomaterials, discusses obstacles to overcome, and pinpoints directions for future research.

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“…Cerium oxide nanoparticles, also called nanoceria, can reduce superoxide anions, hydrogen peroxide, and peroxynitrite by converting between Ce 4+ and Ce 3+ [51]. Similarly, zinc oxide nanoparticles can be used to reduce ROS, and can be engineered for diagnosis and treatment of Alzheimer's Disease [52,53]. Iron, cerium, and zinc all still pose risks for neurotoxic metal buildup, meaning dosage needs to be very carefully controlled in any treatment for neurodegenerative disease [54,55].…”

Section: Current Nanotechnologiesmentioning

confidence: 99%

Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders

Vissers

Ming

Song

2019

Advanced Drug Delivery Reviews

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The convergence of nanoparticles and stem cell therapy holds great promise for the study, diagnosis, and treatment of neurodegenerative disorders. Researchers aim to harness the power of nanoparticles to regulate cellular microenvironment, improve the efficiency of cell and drug delivery to the brain, and enhance the survival of stem cell transplants. Understanding the various properties of different nanoparticles is key to applying them to clinical therapies; the many distinct types of nanoparticles offer unique capacities for medical imaging, diagnosis, and treatment of neurodegeneration disorders. In this review we introduce the biology of Alzheimer's, Parkinson's Disease, and amyotrophic lateral sclerosis, and discuss the potentials and shortcomings of metal, silica, lipid-based, polymeric, and hydrogel nanoparticles for diagnosis and treatment of neurodegenerative disorders. We then provide an overview of current strategies in stem cell therapies and how they can be combined with nanotechnology to improve clinical outcomes.

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In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters

Cited by 44 publications

References 41 publications

Curcuma longa Mediated Synthesis of Copper Oxide, Nickel Oxide and Cu-Ni Bimetallic Hybrid Nanoparticles: Characterization and Evaluation for Antimicrobial, Anti-Parasitic and Cytotoxic Potentials

Curcuma longa Mediated Synthesis of Copper Oxide, Nickel Oxide and Cu-Ni Bimetallic Hybrid Nanoparticles: Characterization and Evaluation for Antimicrobial, Anti-Parasitic and Cytotoxic Potentials

Zinc-Based Biomaterials for Regeneration and Therapy

Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders

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