Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders

Vissers, Caroline; Ming, Guo‐li; Song, Hongjun

doi:10.1016/j.addr.2019.02.007

Cited by 91 publications

(72 citation statements)

References 153 publications

(186 reference statements)

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“…The possibility of using the NWs as MRI contrast agents opens the door for theranostics in diseases such as cancer, where different strategies can be combined for targeting (magnetic guiding and targeting agents) and for treatment, while following the process in a non-invasive manner. Specifically, MRI cell tracking with NWs can be applied for cell therapy in diverse pathologies including degenerative disorders, where pluripotent cells labeled with NWs can be magnetically guided and concentrated into the target site and their differentiation induced by photothermal, magnetic or mechanical responses of the NWs, as suggested in different publications [77][78][79][80].…”

Section: Magnetic Resonance Imaging Of Nanowires Internalized In Breamentioning

confidence: 99%

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

et al. 2020

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Background: Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents. Results: This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core-shell nanowires were evaluated at 1.5 T, revealing a high performance as T 2 contrast agents. Different levels of oxidation and various surface coatings were tested at 7 T. Their effects on the T 2 contrast were reflected in the tailored transverse relaxivities. Finally, the detection of nanowire-labeled breast cancer cells was demonstrated in T 2-weighted images of cells implanted in both, in vitro in tissue-mimicking phantoms and in vivo in mouse brain. Labeling the cells with a nanowire concentration of 0.8 μg of Fe/mL allowed the detection of 25 cells/µL in vitro, diminishing the possibility of side effects. This performance enabled an efficient labelling for high-resolution cell detection after in vivo implantation (~ 10 nanowire-labeled cells) over a minimum of 40 days. Conclusions: Iron-iron oxide core-shell nanowires enabled the efficient and longitudinal cellular detection through magnetic resonance imaging acting as T 2 contrast agents. Combined with the possibility of magnetic guidance as well as triggering of cellular responses, for instance by the recently discovered strong photothermal response, opens the door to new horizons in cell therapy and make iron-iron oxide core-shell nanowires a promising theranostic platform.

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Section: Magnetic Resonance Imaging Of Nanowires Internalized In Breamentioning

confidence: 99%

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

et al. 2020

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“…Currently, NDs can affect about hundreds of millions of people worldwide. Among NDs, more than 50 million people have epilepsy worldwide [1].…”

Section: Neurological Disorders In Peoplementioning

confidence: 99%

Combined Application Therapies of Stem Cells and Drugs in the Neurological Disorder Attenuation

Chen¹,

Hung²,

Lin³

et al. 2021

Novel Perspectives of Stem Cell Manufacturing and Therapies

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Neurological disorders (NDs) are diseases of the central and peripheral nervous system that affected the hundreds of millions of people worldwide. Temporal lobe epilepsy (TLE) is a common NDs with hallucinations and disturbance of consciousness that cause the abnormal neurological activity in any part of brain. Neuroinflammation (NI) has been identified in epilepsy-related tissue from both experimental and clinical evidence and suspected to participate in the formation of neuronal cell death, reactive gliosis and neuroplastic changes in the hippocampus, may contribute to epileptogenesis. The NI is tightly regulated by microglia, but it is thought that excessive or chronic microglial activation can contribute to neurodegenerative processes. Therefore, the modulation of microglia responses may provide a therapeutic target for the treatment of severe or chronic NI conditions. Although the condition responds well to antiepileptic drugs (AEDs), there are still unresponsive to AEDs in about 1/3 of cases. Neural stem cells are the origin of various types of neural cells during embryonic development. Currently, many results of stem cell therapies in the animal experiments and clinical trials were demonstrated the efficacious therapeutic effects in the attenuated symptoms of ND. Therefore, the combined application therapies of stem cells and drugs may be a promising candidate for the therapeutic strategies of NDs, especially TLE.

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“…Among nanoparticles, different biomaterials were investigated in depth for their advantages and disadvantages [ 8 ]. Differentiated by monomer source, researchers worked on metal nanoparticles, metalloid nanoparticles, solid lipid nanoparticles (SLNs), polymeric nanoparticles, liposomes, and extracellular vesicles (EVs) [ 9 ]. There are many misunderstandings regarding nanoparticle nomenclature.…”

Section: Challenges and Implications Of Biomaterials-based Drug Dementioning

confidence: 99%

Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

Kumar

Zhou

Zhi

et al. 2020

IJMS

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Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases.

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Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders

Cited by 91 publications

References 153 publications

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

Combined Application Therapies of Stem Cells and Drugs in the Neurological Disorder Attenuation

Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

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