In vivo T<sub>2</sub>
-based MR thermometry in adipose tissue layers for high-intensity focused ultrasound near-field monitoring

Baron, Paul; Ries, Mario; Deckers, Roel; Greef, Martijn de; Tanttu, Jukka I.; Köhler, Max O.; Viergever, Max A.; Moonen, Chrit; Bartels, Lambertus W.

doi:10.1002/mrm.25025

Cited by 55 publications

(71 citation statements)

References 24 publications

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“…This includes but is not limited to proton density (32), T1 relaxation (33,34), T2 relaxation (35,36), apparent water diffusion (37,38) and magnetization transfer (39). The merits and limitations of MR thermometry based upon these MR parameters are surveyed in an excellent review (40).…”

Section: Overview Of Prf Thermometrymentioning

confidence: 99%

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Winter

Oberacker

Paul

et al. 2015

International Journal of Hyperthermia

176

165

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Clinically established thermal therapies like thermo ablative approaches or adjuvant hyperthermia treatment rely on accurate thermal dose information for the evaluation and adaptation of the thermal therapy. Intratumoral temperature measurements have been correlated successfully with clinical endpoints. Magnetic resonance imaging is the most suitable technique for non-invasive thermometry avoiding complications related to invasive temperature measurements. Since the advent of MR thermometry two decades ago, numerous MR thermometry techniques have been developed continuously increasing accuracy and robustness for in vivo applications. While this progress was primarily focused on relative temperature mapping, current and future efforts will likely close the gap towards quantitative temperature readings. These efforts are essential to benchmark thermal therapy efficiency, understand temperature related biophysical and physiological processes and to use these insights to set new landmarks for diagnostic and therapeutic applications. With that in mind, this review summarizes and discusses advances in MR thermometry providing practical considerations, pitfalls and technical obstacles constraining temperature measurement accuracy, spatial and temporal resolution in vivo. Established approaches and current trends in thermal therapy hardware are surveyed with respect to potential benefits for MR thermometry.3

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Section: Overview Of Prf Thermometrymentioning

confidence: 99%

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Winter

Oberacker

Paul

et al. 2015

International Journal of Hyperthermia

176

165

View full text Add to dashboard Cite

show abstract

“…A variety of MR parameters are indeed sensitive to temperature. These include proton density (1), longitudinal (2,3) and transverse (4) relaxation times, water diffusion constant (5,6) and water proton resonance frequency (PRF) (7). Among them, PRF is the preferred temperature sensor as the water resonance frequency shifts linearly with temperature by about −0.01 ppm/°C over a wide temperature range and in different tissue types (8–10).…”

Section: Introductionmentioning

confidence: 99%

Accurate MR thermometry by hyperpolarized ¹²⁹Xe

Zhang

Burant

McCallister

et al. 2016

Magnetic Resonance in Med

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Purpose To investigate the temperature dependence of the resonance frequency of Lipid-Dissolved Xenon (LDX) and to assess the accuracy of LDX-based MR thermometry. Methods The chemical shift temperature dependence of water protons, methylene protons, and LDX was measured from samples containing tissues with varying fat contents using a high-resolution NMR spectrometer. LDX results were then used to acquire relative and absolute temperature maps in vivo and the results were compared to PRF-based MR thermometry. Results The temperature dependence of PRF is strongly affected by the specific distribution of water and fat. A redistribution of water and fat compartments can reduce the apparent temperature dependence of the water chemical shift from −0.01ppm/°C to −0.006ppm, whereas the LDX chemical shift shows a consistent temperature dependence of −0.21ppm/°C. The use of the methylene protons resonance frequency as internal reference improves the accuracy of LDX-based MR thermometry but degrades that of PRF-based MR thermometry as microscopic susceptibility gradients affected lipid and water spins differently. Conclusion The LDX resonance frequency, with its higher temperature dependence, provides more accurate and precise temperature measurements, both in vitro and in vivo. More importantly, the resonance frequency of nearby methylene protons can be used to extract absolute temperature information.

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“…Although still under investigation, T 2 relaxation time is not particularly used in the context of thermometry, since its temperature dependence can be masked by other factors [15,16]. Similarly, variations in the proton density can be influenced not only by temperature but also by other parameters, such as the relaxation time T 1 .…”

Section: Monitoring Of Tissue Temperature Through T 1 -Weighted Imagesmentioning

confidence: 97%

Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver

Allegretti

Saccomandi

Giurazza

et al. 2015

Medical Engineering & Physics

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In vivo T₂ -based MR thermometry in adipose tissue layers for high-intensity focused ultrasound near-field monitoring

Abstract: The reversibility and linearity of the T2 -temperature dependence of adipose tissue allows for the monitoring of the temperature in the subcutaneous adipose tissue layers.

Cited by 55 publications

References 24 publications

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Accurate MR thermometry by hyperpolarized ¹²⁹Xe

Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver

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In vivo T2 -based MR thermometry in adipose tissue layers for high-intensity focused ultrasound near-field monitoring

Abstract: The reversibility and linearity of the T2 -temperature dependence of adipose tissue allows for the monitoring of the temperature in the subcutaneous adipose tissue layers.

Cited by 55 publications

References 24 publications

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Accurate MR thermometry by hyperpolarized 129Xe

Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver

Contact Info

Product

Resources

About

In vivo T₂ -based MR thermometry in adipose tissue layers for high-intensity focused ultrasound near-field monitoring

Accurate MR thermometry by hyperpolarized ¹²⁹Xe