Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver

Allegretti, Greta; Saccomandi, Paola; Giurazza, Francesco; Caponero, M.; Frauenfelder, Giulia; Matteo, Francesco Maria Di; Zobel, Bruno Beomonte; Silvestri, Sergio; Schena, Emiliano

doi:10.1016/j.medengphy.2015.04.001

Cited by 33 publications

(14 citation statements)

References 31 publications

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“…After a series of experiments on phantoms, ex vivo tissues, and on in vivo animal models [99], MR thermometry has been employed during LA of HCC and liver tumors , prostate cancer, and metastases during the last decade [100,101,102]. Recent studies have shown the possibility of obtaining good spatial and temporal resolution and good precision [103].…”

Section: New Solutions To Guide Laser Ablationmentioning

confidence: 99%

Laser Ablation for Cancer: Past, Present and Future

Schena

Saccomandi

Fong

2017

JFB

138

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Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment.

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Section: New Solutions To Guide Laser Ablationmentioning

confidence: 99%

Laser Ablation for Cancer: Past, Present and Future

Schena

Saccomandi

Fong

2017

JFB

138

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“…FBGs sensor are a valid alternative to non-invasive procedure because by inserting only one fiber optic they are able to perform distributed measurements. Several studies have been monitored the effects of thermal treatments by FBGs either on ex vivo organs and phantoms or on small animals [12,13,15,17,28,29,30]. All these experiments do not take into account the effect of the respiratory movements on the FBGs' output.…”

Section: Correction Of the Artefact: Ex Vivo Analysismentioning

confidence: 99%

“…They can be split in two main categories [9]: i) invasive methods, which need the transducer to be in contact with the tissue. The most popular sensors used in this field are thermocouples [10,11], and fiber optic sensors [12,13]; ii) non-invasive methods based on the analysis of diagnostic imaging techniques, such as, Magnetic Resonance (MR) [14,15], Computed Tomography [16,17], and Ultrasound [18].…”

Section: Introductionmentioning

confidence: 99%

Error of a Temperature Probe for Cancer Ablation Monitoring Caused by Respiratory Movements: <italic>Ex Vivo</italic> and <italic>In Vivo</italic> Analysis

et al. 2016

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Hyperthermal techniques are spreading as an alternative to conventional surgery for cancer removal. A real-time temperature feedback can be used to adjust the treatment settings, in order to improve the clinical outcomes. In this paper, we experimentally assessed the feasibility for distributed temperature monitoring of a custom probe, which consists of a needle embedding six fiber Bragg gratings (FBGs). Since FBGs are also sensitive to strain, we focused on the analysis of the measurement error (artifact) caused by respiratory movements. We assessed the artifact both on ex vivo pig liver and lung (by mimicking the movement of these organs caused by respiration) and on in vivo trial on pig liver. Lastly, we proposed an algorithm to detect and minimize the artifact during ex vivo liver laser ablation. During both ex vivo and in vivo trials, the probe insertion within the organ was easy and safe. The artifact was significant (up to 3 °C), but the correction algorithm allows minimizing the error. The main advantages of the proposed probe are: 1) spatially resolved temperature monitoring (in six points of the tissue by inserting a single needle) and 2) the needle is magnetic resonance (MR)-compatible, hence can be used during MR-guided procedure. Even if the model is close to humans, further trials are required to investigate the feasibility of the probe for clinical applications.

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“…There were emerging animal studies focused on laser ablation for pancreas. [15–17] In swine model, laser ablation was used for normal pancreatic tissue, with an output power of 2 and 3 W and a total delivered energy of 500 and 1000 J. [18] The ablation area was between 49 and 80 mm 2 without major postoperative complications.…”

Section: Introductionmentioning

confidence: 99%

US-guided percutaneous laser ablation of refractory metastatic retroperitoneal lesions

Tian

2017

Medicine

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Rationale:Retroperitoneal metastatic lymph node is rare but severe, which has important structures like the gastrointestinal tract and large blood vessels around and may challenge excision, inducing serious complications like hemorrhage, intestinal adhesion, and even death after injury.Patient concerns:We described the case of a 60-year-old man with a history of right liver resection in 2010, pulmonary wedge resection in 2012, and transarterial chemoembolization twice in 2014, in which the postoperative pathology suggested the mixed liver cancer, and poorly differentiated lung cancer from liver metastasis.Diagnoses:Preoperative magnetic resonance (MR) imaging scan showed a refractory retroperitoneal metastatic lymph node.Interventions:Then this patient repeatedly received 4 ablations with US-guided laser ablation within a month.Outcomes:After 4 ablations due to residual tumor, MR, and CT images of 5-month follow-up showed the partial response. No obvious side effects were discovered in this case during these procedures.Lessons:This suggested US-guided laser ablation appears to be a useful technique for retroperitoneal metastatic lymph node with poor general condition or those refusing surgical therapy.

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Magnetic resonance-based thermometry during laser ablation on ex-vivo swine pancreas and liver

Cited by 33 publications

References 31 publications

Laser Ablation for Cancer: Past, Present and Future

Laser Ablation for Cancer: Past, Present and Future

Error of a Temperature Probe for Cancer Ablation Monitoring Caused by Respiratory Movements: <italic>Ex Vivo</italic> and <italic>In Vivo</italic> Analysis

US-guided percutaneous laser ablation of refractory metastatic retroperitoneal lesions

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