In vivo sup 1 H MRS of brain abscesses versus necrotic brain tumors

Abstract

References 1. Dancis J, Cox RP. Errors of lysine metabolism. In: Scriver CR, Beaudet AL, Sly WS, Vale D, eds. The metabolic basis of inherited disease, vol 1. McGraw-Hill Inc, 1989:665-670. 2. Dancis J, Hutzler J, Ampola M, et al. The prognosis of hyperlysinaemia: an interim report. Am J Hum Genet 1983;35:438-442, 3. Gregory JW, Beal N, Boyle NA, Dobrowski C, Jackson P. Dietary treatment of hyperlysinaemia. Arch Dis Child 1989;64:716-720. 4. Heiden C, Brink M, de Bree PK, et al. Familial hyperlysinaemia due to L-lysine alpha-ketoglutarate reductase deficiency: results of attempted treatment. J Inherit Metab Dis 1978;1:89-94.

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…These enzymes hydrolyze the proteins into AAs, which are detected at 0.9 ppm on in vivo 1 H-MR spectroscopy in pyogenic brain abscesses. [15][16][17][18][19] However; we could not find AAs at 0.9 ppm in some of the patients having aerobes, anaerobes, facultative anaerobes, and sterile cultures. The absence of AAs in sterile abscesses was probably due to the fact that these patients were undergoing treatment with antibiotics 20-24 before the in vivo 1 H-MR spectroscopy, probably resulting in the lack of bacterial growth on the culture.…”

In Vivo Differentiation of Aerobic Brain Abscesses and Necrotic Glioblastomas Multiforme Using Proton MR Spectroscopic Imaging

“…[21][22][23][24] Typical features of MR spectra from anaerobic bacterial abscesses, such as succinate or acetate or increased amino acid resonances, were not detectable in Staphylococcal aureus (facultative aerobic bacteria) abscesses in rats or humans. 17,18,[21][22][23][24] Acetate, which is often referred to as a "marker" metabolite for in vivo diagnosis of bacterial abscesses at MR spectroscopy, [17][18][19][20][21][22] was usually absent in aerobic bacteria abscesses. Thus, interpretation of in vivo MR spectra by resonance assignment could allow us to distinguish between abscesses due to aerobic bacteria and those where anaerobic bacteria are present.…”

“…A TE of 136 ms was used to confirm the phase inversion associated with J-coupled metabolites of lactate (1.3 ppm) and cytosolic amino acids (0.9 ppm) but not of lipids, which may be helpful in discriminating lactate or amino acid signals from lipid signals. [17][18][19][20][21][22] The acquisition time for each sequence was 5 minutes and 45 seconds. The MR spectroscopy data files were transferred to an off-line workstation for postprocessing by 2 experienced neuroradiologists independently by using FuncTool software (GE Medical Systems).…”

“…8,[12][13][14][15][16] Single-voxel proton MR spectroscopy of the central cystic portion has been reported to allow the broad group of pyogenic abscesses to be distinguished from malignant gliomas. [17][18][19][20][21][22] Acetate, succinate, and amino acids have been identified in cerebral abscesses in humans and were used as bacterial marker metabolites for noninvasive diagnosis by MR spectroscopy. [17][18][19][20][21][22] Abscesses caused by anaerobic bacteria have been distinguished from those caused by aerobic bacteria based on metabolites detectable with MR spectroscopy (acetate and succinate).…”

“…[17][18][19][20][21][22] Acetate, succinate, and amino acids have been identified in cerebral abscesses in humans and were used as bacterial marker metabolites for noninvasive diagnosis by MR spectroscopy. [17][18][19][20][21][22] Abscesses caused by anaerobic bacteria have been distinguished from those caused by aerobic bacteria based on metabolites detectable with MR spectroscopy (acetate and succinate). [21][22][23] However, spectral patterns recorded for the cystic or necrotic components of GBMs and abscesses caused by aerobic bacteria (aerobic abscesses) were similar by single-voxel MR spectroscopy.…”