“…13,14) While lipid based controlled release systems have been developed successfully for insoluble or slightly soluble drugs, development of similar system for highly aqueous soluble drugs still remains a challenging task; and due to the fact that lipids have specific physical properties and are distinctive from other commonly used excipients (like polymers), they are difficult to incorporate into formulation in quantities suitable for controlled/sustained release products. As a result, the pharmaceutical scientists have reported different ways of incorporating lipids into oral controlled/sustained release formulations like HMCP, [5][6][7][8] organic solvent coating process, 9) physical mixtures and solid dispersions of drugs and lipids, [15][16][17] melt granulation, 18,19) and lubrication. 20) When compared with HMCP, these other approaches require significantly more lipid material for similar sustained release profile, which can be a limiting factor for high dose drugs.…”