In vivo study of propolis supplementation effects on antioxidative status and red blood cells

Jasprica, Ivona; Mornar, Ana; Debeljak, Željko; Smolčić-Bubalo, Asja; Medić-Šarič, Marica; Mayer, Ljiljana; Romić, Željko; Bućan, Kajo; Balog, Tihomir; Sobočanec, Sandra; Šverko, Višnja

doi:10.1016/j.jep.2006.10.023

Cited by 138 publications

(107 citation statements)

References 30 publications

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“…There were bidirectional changes in antioxidant enzyme activities, yet these changes were also statistically insignificant, demonstrating that the administration of propolis alone has no effects on rats. On the other hand, in a human study carried out by Jasprica et al [21], propolis was reported to cause a decrease in the MDA level and an increase in SOD activity. Both the origin and composition of propolis are considered to be reasons why similar results were not obtained in the present study.…”

Section: Administration Of Propolis Alonementioning

confidence: 88%

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Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

et al. 2008

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Section: Administration Of Propolis Alonementioning

confidence: 88%

“…Propolis is a biological material collected by bees from various plants. The mechanism underlying the antioxidant effect of propolis is its high content of flavonoids which scavenge free radicals [2,19,21,29,37,38].…”

Section: Introductionmentioning

confidence: 99%

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

et al. 2008

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“…The benefit of propolis use was shown in male population demonstrating reduction in freeradical-induced lipid peroxidation as well as increase in activity of superoxide dismutase. Further a decrease in malonaldehyde (degradation product of peroxidation of polyunsaturated fatty acids) concentration and increase in superoxide dismutase activity (first and most important line of antioxidant enzyme defense) were observed (Jasprica et al, 2007).…”

Section: Anti-inflammatory and Immunomodulatory Response To Propolis mentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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“…Honeybee gum helps to resist aging, heart disease, liver disease, skin, stomach, intestine and colon cancer [5,6]. Honeybee gum was used around the world for thousands of years in folk medicine as an anti-microbial and anti-ulcer and tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Jasprica et al [5] mentioned that the honeybee gum improved the hepatic effects as a result of liver damage in experimental rats treated with paracetamol pills. The study concluded that honeybee gum and its components of Flavonoid reduce free radicals like superoxide and hydroxyl.…”

Section: Introductionmentioning

confidence: 99%

Effect of Saudi Propolis on Hepatitis Male Rats

E¹,

Elhendy²,

Mas³

et al. 2017

J Nutr Food Sci

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This study was conducted to evaluate the benefits of the Saudi gum (propolis) by reduction of the toxic substances in rats that target the liver and affect its performance. The chemical components of propolis were identified. The study included 42 Albino male rat of a healthy weight ranged from 255-287 g, and they were divided into six equal groups. The first group was fed the standard diet (negative control group), while the other 35 rats were injected with carbon tetrachloride under the skin (1.5 ml/ kg) in order to infect them with acute hepatitis. After 24 h, the groups of infected rats were divided and the second group (positive control group) was also fed a standard meal, while the other groups infected which were the third, fourth, fifth and sixth were fed on a diet with access to a standard concentration of Saudi bee gum of 200, 300, 400 and 500 mg/kg, respectively, through the mouth for 4 consecutive weeks. The results showed that propolis contains 41 compounds and out of these 17 compounds have been identified. Volatile oil was in proportion of 20.37%, aliphatic acids in 16.87%, and esters in 15.48% and alcohols in 13.98%. The results showed a significant improvement in the biochemical parameters in hepatitis rats which were treated with propolis. Results also showed that propolis increased the activity of antioxidant enzymes in the liver of hepatitis rats treated with propolis. The study concluded that propolis plays an effective role in protecting the liver from damage and inflammation that can be caused by the components of antioxidation and inflammation.

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In vivo study of propolis supplementation effects on antioxidative status and red blood cells

Cited by 138 publications

References 30 publications

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Effecs of Cypermethrin on Some Biochemical Changes in Rats: The Protective Role of Propolis

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Effect of Saudi Propolis on Hepatitis Male Rats

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