In vivo study of genotoxicity and teratogenicity of silica nanocrystals

Дурнев, А. Д.; Solomina, A. S.; Shreder, E. D.; Немова, Е. П.; Shreder, O. V.; Даугель-Дауге, Н. О.; Жанатаев, А. К.; Veligura, V. A.; Osminkina, L.A.; Gongalsky, M. B.; Timoshenko, V. Yu.; Середенин, С. Б.

doi:10.1504/ijbnn.2010.034126

Cited by 11 publications

(12 citation statements)

References 21 publications

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“…Afobazole diminishes the genotoxic effect of tobacco smoke in embryonic tissues and placenta, which is consistent with published data on the antimutagenic and antiteratogenic properties of this agent in relation to chemical mutagens and teratogens [2,5]. It should be emphasized that the protective effect was most pronounced after treatment with afobazole in a dose of 1 mg/kg.…”

Section: Resultssupporting

confidence: 90%

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cEffect of Afobazole on Genotoxic Effects of Tobacco Smoke in the Placenta and Embryonic Tissues of Rats

et al. 2010

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The DNA comet assay was used to evaluate the severity of genotoxic changes in embryonic tissues and placenta of rats daily exposed to tobacco smoke per se or in combination with an anxiolytic agent afobazole. The exposure to tobacco smoke (4 cigarettes containing 13 mg tar and 1 mg nicotine per 72 dm(3)) for 20 min on days 1-13 of pregnancy increased the degree of DNA damage and elevation of apoptotic DNA comets in cells of the placenta and embryo from pregnant rats. Afobazole (1 and 10 mg/kg orally) reduced the genotoxic effect of tobacco smoke and decreased the amount of apoptotic DNA comets in placental tissue and embryonic tissue from rats.

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Section: Resultssupporting

confidence: 90%

“…Published data indicate that many substances (e.g., medical products) exhibit antimutagenic properties [5]. They include anxiolytic drug afobazole, which produced the antigenotoxic and antiteratogenic effect in experiments with cyclophosphamide [2].…”

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confidence: 99%

cEffect of Afobazole on Genotoxic Effects of Tobacco Smoke in the Placenta and Embryonic Tissues of Rats

et al. 2010

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“…The marked increase of cell resistance to the DNA damaging and cytotoxic action of H 2 O 2 ex vivo suggests that the protective effect of afobazole is associated with its infl uence on the effi cacy of cellular antioxidant defense system. This conclusion is in line with the known data on the antioxidant effects of afobazole and experimentally shown in vivo inhibition of the clastogenic effects of dioxidine, a mutagen with prooxidant action type, by afobazole [2]. , and HD cells (c) in blood cells of SLE patients before and after the corresponding treatment.…”

Section: Resultssupporting

confidence: 90%

“…The aim of this study was to investigate DNA damage in blood cells from SLE patients and their resistance to genotoxic action of H 2 O 2 before and after administration of anxiolytic afobazole exhibiting pronounced cytoprotective, antioxidant, and antimutagenic properties [2].…”

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confidence: 99%

Effect of Afobazole on DNA Damage in Patients with Systemic Lupus Erythematosus

et al. 2009

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Using comet assay we studied the effect of anxiolytic afobazole, exhibiting also antioxidant and antimutagenic properties, on spontaneous and ex-vivo hydrogen peroxide-induced DNA damage in blood cells from patients with systemic lupus erythematosus. Afobazole treatment (30-60 mg/day for 1 month) in addition to standard therapy decreased spontaneous level of DNA damage in blood cells. The level of ex vivo hydrogen peroxide-induced DNA damage decreased by 49% in this group of patients. The number of cells hypersensitive to hydrogen peroxide yielding DNA comets with highly damaged DNA also decreased by 51%. No significant changes in the analyzed parameters were found in the placebo group. Addition of afobazole to complex therapy of patients with systemic lupus erythematosus reduced the level of DNA damage in blood cells and improved cell resistance to oxidative genotoxic exposure.

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“…in [4,5]. In [7] rather low genotoxicity and teratogenicity of SiNPs were found in vivo. Also in vivo experiments on the biocompatibility of thermally oxidized PSi films in eye tissues revealed the possibility of improving existing therapies # 2012 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Journal of BIOPHOTONICS Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro.…”

Section: Introductionmentioning

confidence: 96%

Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

Осминкина

Tamarov

Sviridov

et al. 2012

Journal of Biophotonics

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Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be filled by SiNPs, which exhibited bright photoluminescence at 1.6 eV. SiNPs could also act as photosensitizers of the singlet oxygen generation, which could be used in the photodynamic therapy of cancer. These properties of SiNPs are discussed in view of possible applications in theranostics (both in therapy and in diagnostics).

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In vivo study of genotoxicity and teratogenicity of silica nanocrystals

Cited by 11 publications

References 21 publications

cEffect of Afobazole on Genotoxic Effects of Tobacco Smoke in the Placenta and Embryonic Tissues of Rats

cEffect of Afobazole on Genotoxic Effects of Tobacco Smoke in the Placenta and Embryonic Tissues of Rats

Effect of Afobazole on DNA Damage in Patients with Systemic Lupus Erythematosus

Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

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