Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

Осминкина, Л. А.; Tamarov, Konstantin; Sviridov, Andrey; Galkin, R. A.; Gongalsky, M. B.; Solovyev, V. V.; Kudryavtsev, A. A.; Timoshenko, V. Yu.

doi:10.1002/jbio.201100112

Cited by 77 publications

(56 citation statements)

References 17 publications

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“…Another important feature of porous SiNPs is that they can be precisely engineered as photonic crystals with photoluminescent properties and provide theranostic functions such as in‐vivo imaging and self‐reporting, drug‐release and degradation . In addition, these properties of pSi can be readily used as a photosensitizer to generate oxygen species for photodynamic cancer therapy . Another advantage is that, upon SiNPs administration into the body, these drug carriers accumulate at the tumor site rather than at normal tissues or organs by a nonspecific targeting process known as EPR effect, a process linked to the leaky vasculature and poor lymphatic drainage present in solid tumors sites …”

Section: Introductionmentioning

confidence: 99%

From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics

Maher

Kumeria

Wang

et al. 2016

Adv Healthcare Materials

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Drug delivery using synthetic nanoparticles including porous silicon has been extensively used to overcome the limitations of chemotherapy. However, their synthesis has many challenges such as lack of scalability, high cost, and the use of toxic materials with concerning environmental impact. Nanoscale materials obtained from natural resources are an attractive option to address some of these disadvantages. In this paper, a new mesoporous biodegradable silicon nanoparticle (SiNP) drug carrier obtained from natural diatom silica mineral available from the mining industry is presented. Diatom silica structures are mechanically fragmented and converted into SiNPs by simple and scalable magnesiothermic reduction process. Results show that SiNPs have many desirable properties including high surface area, high drug loading capacity, strong luminescence, biodegradability, and no cytotoxicity. The in-vitro release results from SiNPs loaded with anticancer drugs (doxorubicin) demonstrate a pH-dependent and sustained drug release with enhanced cytotoxicity against cancer cells. The cells study using doxorubicin loaded SiNPs shows a significantly enhanced cytotoxicity against cancer cells compared with free drug, suggesting their considerable potential as theranostic nanocarriers for chemotherapy. Their low-cost manufacturing using abundant natural materials and outstanding chemotherapeutic performance has made them as a promising alternative to synthetic nanoparticles for drug delivery applications.

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Section: Introductionmentioning

confidence: 99%

From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics

Maher

Kumeria

Wang

et al. 2016

Adv Healthcare Materials

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“…First, Si NPs are not only biocompatible12, but also biodegradable as in biological tissue they normally decay into orthosilicic acid Si(OH) 4 , which is naturally excreted from the body through the urine13. Second, due to a series of unique properties, including room temperature photoluminescence1213, singlet oxygen generation under photoexcitation14, infrared radiation–induced15 and ultrasound-induced16 hyperthermia, Si NPs can offer diagnostic1718 and alternative treatment modalities (e.g., Photodynamic Therapy1920) that can be applied in parallel to the RF hyperthermia approach.…”

mentioning

confidence: 99%

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Tamarov

Осминкина

Zinovyev

et al. 2014

Sci Rep

Self Cite

156

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Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50°C under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1–5 W/cm2). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinoma in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

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“…Thanks to their emission in the NIR region, they were also used for in vivo imaging, as it will be discussed in Section 8. 330 Osminkina et al demonstrated that these NPs penetrate the cytoplasm in the case of CF2Th cells showing an emission at about 750 nm showing no cytotoxic effect up to the concentration of 100 mg ml À1 in the dark. The NPs were prepared by electrochemical etching of single-crystal silicon wafers in ethanolic HF solution.…”

Section: Si Qds From Electrochemical Etchingmentioning

confidence: 99%

Nanodiamonds and silicon quantum dots: ultrastable and biocompatible luminescent nanoprobes for long-term bioimaging

2015

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Fluorescence bioimaging is a powerful, versatile, method for investigating, both in vivo and in vitro, the complex structures and functions of living organisms in real time and space, also using super-resolution techniques. Being poorly invasive, fluorescence bioimaging is suitable for long-term observation of biological processes. Long-term detection is partially prevented by photobleaching of organic fluorescent probes. Semiconductor quantum dots, in contrast, are ultrastable, fluorescent contrast agents detectable even at the single nanoparticle level. Emission color of quantum dots is size dependent and nanoprobes emitting in the near infrared (NIR) region are ideal for low back-ground in vivo imaging. Biocompatibility of nanoparticles, containing toxic elements, is debated. Recent safety concerns enforced the search for alternative ultrastable luminescent nanoprobes. Most recent results demonstrated that optimized silicon quantum dots (Si QDs) and fluorescent nanodiamonds (FNDs) show almost no photobleaching in a physiological environment. Moreover in vitro and in vivo toxicity studies demonstrated their unique biocompatibility. Si QDs and FNDs are hence ideal diagnostic tools and promising non-toxic vectors for the delivery of therapeutic cargos. Most relevant examples of applications of Si QDs and FNDs to long-term bioimaging are discussed in this review comparing the toxicity and the stability of different nanoprobes.

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Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

Cited by 77 publications

References 17 publications

From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics

From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Nanodiamonds and silicon quantum dots: ultrastable and biocompatible luminescent nanoprobes for long-term bioimaging

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