In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse

Huang, Yuan; Leu, Sew Fen; Liu, Bi Ching; Sheu, Chia Chin; Huang, Bu Miin

doi:10.1016/j.lfs.2004.01.029

Cited by 43 publications

(35 citation statements)

References 29 publications

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“…Previous reports confirmed that C. sinensis could stimulate testosterone production both in-vivo and in-vitro, and it is possible that the polysaccharides and/or glycoproteins in extracts might be structurally similar to LH. These could possess the ability to recognize LH receptors on Leydig cells to stimulate testosterone production [Hsu et al 2003a;Huang et al 2001;Huang et al 2004]. Hsu et al [2003b] also proved that C. sinensis could activate the cAMP-protein kinase-A signal pathway.…”

Section: Discussionmentioning

confidence: 92%

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Wang

Chen

Jiang

et al. 2016

Systems Biology in Reproductive Medicine

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Section: Discussionmentioning

confidence: 92%

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Wang

Chen

Jiang

et al. 2016

Systems Biology in Reproductive Medicine

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“…Indeed, Cordyceps sp. has been shown to significantly increase serum testosterone levels in mice (Huang et al, 2004). Secondly, cordyceps extract may act on microbial flora.…”

Section: Discussionmentioning

confidence: 98%

“…C. militaris was reported to improve insulin resistance and insulin secretion (Cheng et al, 2012). This medicinal fungus was used traditionally to cure hyposexuality and hyperlipidemia (Huang et al, 2004;Guo et al, 2010), and to treat asthma and lung inflammation (Wang et al, 2007). In turn, C. militaris is known to demonstrate antiviral activity (Jiang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

Cheng¹,

Wen²,

Dybus³

et al. 2016

SA J. An. Sci.

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The aim of this study was to investigate the effect of supplementation of Cordyceps militaris fermentation products (CMF) on growth performance and immunocompetence of piglets. The study involved three groups of animals, which were supplemented with CMF (500, 1000 and 1500 μg/kg feed), and a control group. CMF supplementation significantly increased growth performance in weaned piglets. Bodyweight gain, average daily gain and feed intake in animals supplemented with 1000 µg CMF/kg feed were significantly higher in comparison with the control group. In addition, CMF supplementation only significantly increased the synthesis of Th1 cytokines, as indicated by the levels of IL-2 and IFN-γ. The piglets fed with the CMF supplement displayed an increased cellular immune response. Indeed, alveolar macrophages isolated from piglets supplemented with 1000 and 1500 µg CMF/kg feed had significantly higher chemotactic and phagocytic indices than those isolated from piglets that received the control feed or feed supplemented with 500 µg CMF/kg. In relation to the absence of effect on Th2 cytokines, the CMF supplement had no effect on hog cholera antibody titre. In summary, feed supplementation with CMF improves growth performance and enhances cell-mediated immunity. CMF supplementation may thus be useful at weaning to counteract physiological and immunological stress during this period. ______________________________________________________________________________________

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“…Cordyceps species including Cordyceps sinensis (CS) and C. militaris (CM) has been used as Chinese traditional herb for centuries (Zhu et al, 1998). It has been reported that CS can induce the steroidogenic enzyme estradiol-17 (E2) expression in human granulosa-lutein cells (GLC) and testosterone in primary mouse Leydig cells and MA-10 mouse Leydig tumor cells (Hsu et al, 2003;Huang et al, 2004). CS is comparatively rare in nature and cannot be easily grown in culture, whereas CM occurs worldwide and forms fruiting bodies well.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

Hong¹,

Choi²,

Woo³

et al. 2011

International Journal of Industrial Entomology

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Some of men have been suffered from the insufficient secretion of testosterone causing by physical factors, social and psychological factors. Testosterone is an essential steroid hormone controlling male reproductive function. Alternative medicines in plants, fungi, and insects have been studied to enhance sexuality. Cordyceps species including Cordyceps sinensis (CS) and C. militaris(CM) has been used as for the enhancement of sexual functionfor hundreds of years in Far East Asian. In the present study, we determined the effect of fruiting bodies of C. militaris which cultured on bee drone medium (CMD) and brown rice medium (CMB) on testosterone concentration in Sprague-Dawley rats. Eighteen rats per group were housed to regular diet or diet supplemented with CMB and CDD, respectively for 4 weeks. Serum was collected from 6 rats per group. Results showed that changes of the body weight, food and water intake of the rats were not observed in this study. However, both CMB and CDD increased the serum testosterone concentration in rats. Furthermore, CMD significantly stimulated testosterone production (p <0.05) compared to the control. Hence, it suggests that C. militaris fruiting bodymight be developed as a complementary medicine to improve sexual hormones.

show abstract

In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse

Cited by 43 publications

References 29 publications

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

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