In Vivo Sol–Gel Reaction of Tantalum Alkoxide for Endovascular Embolization

Ko, Giho; Choi, Jin Woo; Shin, Kwang‐Soo; Kim, Young Geon; Kang, Thomas H.‐K.; Kim, Dokyoon; Lee, Jun Young; Kim, Hyo Cheol; Hyeon, Taeghwan

doi:10.1002/adhm.202101908

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…Ko et al . developed tantalum alkoxide liquid embolic (TALE) based on tantalum ethoxide [ 39 ]. This is a novel multifunctional embolic agent that can be observed under X-ray fluoroscopy.…”

Section: Function Of Hydrogelsmentioning

confidence: 99%

“…can be prepared for various treatments for liver cancer, such as chemotherapy, photothermal therapy, magnetothermal therapy, photodynamic therapy, and immunotherapy, or a combination of treatments can be used to achieve better therapeutic results [ 38 ]. After imaging materials, such as tantalum powder, lipiodol, and magnetic nanoparticles, were combined with hydrogels, new hydrogels materials with imaging capabilities were prepared for visualization under imaging devices, such as X-ray, CT, MRI, or ultrasound [ 39 – 41 ]. Furthermore, researchers created in vitro 3D models of liver cancer based on hydrogels, such as organoids, 3D tumor spheres, and organ chips, that can replicate the spatial structure, microenvironment, and pathological functions of liver cancer in vivo, as well as other key features.…”

Section: Introductionmentioning

confidence: 99%

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Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Xu,

Liu,

Liu

et al. 2024

J Nanobiotechnol

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Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide and is characterized by high rates of morbidity and mortality, posing a serious threat to human health. Interventional embolization therapy is the main treatment against middle- and late-stage liver cancer, but its efficacy is limited by the performance of embolism, hence the new embolic materials have provided hope to the inoperable patients. Especially, hydrogel materials with high embolization strength, appropriate viscosity, reliable security and multifunctionality are widely used as embolic materials, and can improve the efficacy of interventional therapy. In this review, we have described the status of research on hydrogels and challenges in the field of HCC therapy. First, various preparation methods of hydrogels through different cross-linking methods are introduced, then the functions of hydrogels related to HCC are summarized, including different HCC therapies, various imaging techniques, in vitro 3D models, and the shortcomings and prospects of the proposed applications are discussed in relation to HCC. We hope that this review is informative for readers interested in multifunctional hydrogels and will help researchers develop more novel embolic materials for interventional therapy of HCC. Graphical Abstract

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“…Ko et al . developed tantalum alkoxide liquid embolic (TALE) based on tantalum ethoxide [ 39 ]. This is a novel multifunctional embolic agent that can be observed under X-ray fluoroscopy.…”

Section: Function Of Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Xu,

Liu,

Liu

et al. 2024

J Nanobiotechnol

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“…Hereinto solid embolic agents, e.g., coil , and gelatin sponges, are used more frequently, but are prone to inflammation and tissue hyperplasia. In comparison, some novel liquid embolic agents (e.g., cyanoacrylate and ethylene-vinyl alcohol copolymer (EVOH) , ) can not only reach the distal peripheral vascular system, but also adjust the penetration depth …”

mentioning

confidence: 99%

Smart “Thrombus”: Self-Localizing UCST-Type Microcage

Gan

Dong

et al. 2023

ACS Macro Lett.

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Embolization is often used to block blood supply for controlling the growth of fibroids and malignant tumors, but limited by embolic agents lacking spontaneous targeting and posttreatment removal. So we first adopted nonionic poly(acrylamideco-acrylonitrile) with an upper critical solution temperature (UCST) to build up self-localizing microcages by inverse emulsification. The results showed that these UCST-type microcages behaved with the appropriate phase-transition threshold value around 40 °C, and spontaneously underwent an expansion−fusion−fission cycle under the stimulus of mild temperature hyperthermia. Given the simultaneous local release of cargoes, this simple but smart microcage is expected to act as a multifunctional embolic agent for tumorous starving therapy, tumor chemotherapy, and imaging.

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Intravascular Casting Radiopaque Hydrogel Systems for Transarterial Chemo/Cascade Catalytic/Embolization Therapy of Hepatocellular Carcinoma

Lee,

Choi,

Hwang

et al. 2024

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This paper introduces catheter‐directed intravascular casting hydrogels for transarterial chemo/starvation/chemodynamic embolization (TACSCE) therapy of hepatocellular carcinoma (HCC). Comprising Mn ion‐crosslinked hyaluronic acid‐dopamine (HD) with glucose oxidase (for glucose decomposition to H2O2 in starvation therapy), doxorubicin (for chemotherapy), and iopamidol (for X‐ray imaging), these hydrogels are fabricated for transarterial embolization therapy guided by X‐ray fluoroscopy. Mn4+ (from MnO2) demonstrates strong coordination with the catechol group of HD, providing hypoxia relief through O2 generation and cellular glutathione (GSH) consumption, compared to the OH radical generation potential of Mn2+. The gelation time‐controlled, catheter‐injectable, and rheologically tuned multitherapeutic/embolic gel system effectively reaches distal arterioles, ensuring complete intravascular casting with fewer complications related to organic solvents. Glucose deprivation, cascade reactive oxygen species (ROS) generation, GSH depletion, and sustained release profiles of multiple drug cargos from the hydrogel system are also achieved. The combined chemo/starvation/chemodynamic efficacies of these designed hydrogel systems are confirmed in HCC cell cultures and HCC‐bearing animal models. The developed radiopaque/injectable/embolic/sol‐to‐gel transformable systems for TACSCE therapy may offer enhanced therapeutic efficacies compared to typical transarterial embolization and transarterial chemoembolization procedures for HCC.

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In Vivo Sol–Gel Reaction of Tantalum Alkoxide for Endovascular Embolization

Cited by 5 publications

References 40 publications

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model

Smart “Thrombus”: Self-Localizing UCST-Type Microcage

Intravascular Casting Radiopaque Hydrogel Systems for Transarterial Chemo/Cascade Catalytic/Embolization Therapy of Hepatocellular Carcinoma

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