In vivo Sedative and Anxiolytic Potential in Mice for Methanolic Extract of Tinospora cordifolia

Hossain, Rashadul; Barua, Anik; Hossain, Rabiul; Banik, Parmita; Sultana, Rajia; Absar, Nurul

doi:10.3923/tasr.2019.193.198

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…We observed that TC, HF, and CF showed significant antinociceptive activity in both tests. The rationale for screening TC and its fractions for their activity on the central nervous system (CNS) was based on the knowledge that some sedative and anxiolytic effects had previously been reported for another species of Tinospora (Barua et al, 2019;Mishra et al, 2016). The open field test was used to measure the behavioral and locomotor activity of mice (Tatem et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Its extracts and/or isolated compounds have demonstrated antiinflammatory, immunomodulatory, cytotoxic, antioxidant, antinociceptive, antipyretic, hepatoprotective, antimalarial, hypoglycaemic, antifilarial, and cardioprotective activities (Ahmad et al, 2016;Rakib et al, 2019). Another species of Tinospora (T. cordifolia) has been shown to exhibit sedative and anxiolytic effects (Barua et al, 2019;Mishra et al, 2016).…”

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Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa

Rakib

Ahmed

et al. 2020

Phytotherapy Research

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Tinospora crispa (TC), and of its hexane (HF) and chloroform (CF) fractions. Significant antinociceptive activity was observed for TC, HF, and CF in the acetic acid-induced writhing and formalin-induced paw licking tests. Anxiolytic and antidepressant activities were assessed using the open field, hole board, and elevated plus maze (EPM) tests. TC, HF, and CF demonstrated a significant decrease in spontaneous locomotor activity. They also showed an increase in the number of head-dippings in the holeboard test, suggesting decreased fearfulness. TC, and most of its fractions, showed a significant increase of the time spent in the opened arm of the EPM, indicating reduced anxiety. This study provides some support to explain the traditional use of T. crispa as a remedy for pain.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa

Rakib

Ahmed

et al. 2020

Phytotherapy Research

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Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders

Singh

Sharma

et al. 2022

Curr Pharmacol Rep

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New Insight in the Sedative and Anxiolytic Activities of Amaranthus tricolor L. Leaves Extract in Mice

Jahan

Hossain

et al. 2020

AFSJ

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Aims: The present study was planned to assess the sedative and anxiolytic efficacy of Amaranthaus tricolor L methanolic extract in vivo. Place and Duration of Study: Department of Pharmacy, between January 2018 and August 2018. Methodology: In this experiment, the crude extract of Amaranthus tricolor L. was evaluated for its CNS depressant effect using rodent behavioral models, such as open field, hole cross and rota rod tests for its sedative properties and an elevated plus maze test for its anxiolytic potential, respectively. Results: In sedative assay, a dose-dependent and statistically significant (p<0.05) suppression of locomotors activity of the mice in both open field and hole cross test was exhibited by theextract at a dose of 200 and 400 mg/kg body weight. The extract also displayed increased percentage of entry into open arms at both doses in anxiolytic potential study. At a dose of 400 mg/kg body weight significant anxiolytic activity (p<0.05) was found compared to the standard diazepam. Conclusion: The pivotal CNS depressant and anxiolytic activity of the methanolic extract of Amaranthus tricolor L leaves was discovered in this experiment. Further research on the extract's biologically active phytochemicals may provide access to therapeutic intervention.

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In vivo Sedative and Anxiolytic Potential in Mice for Methanolic Extract of Tinospora cordifolia

Cited by 3 publications

References 19 publications

Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa

Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa

Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders

New Insight in the Sedative and Anxiolytic Activities of Amaranthus tricolor L. Leaves Extract in Mice

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