In Vivo Real-Time Intravascular MRI

Rivas, Pedro A.; Nayak, Krishna S.; Scott, Greig; McConnell, Michael V.; Kerr, Adam B.; Nishimura, Dwight G.; Pauly, John M.; Hu, B. L.

doi:10.1081/jcmr-120003948

Cited by 24 publications

(17 citation statements)

References 42 publications

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“…Several designs for IVMRI detector coils exist: some incorporate a loop (twin-lead design) or a solenoid (single or paired) to maximize SNR, but at present, these devices are too bulky for clinical application 8 ; a loopless detector coil …”

Section: Table 3 Clinical Characteristics Of the 25 Subjects In The mentioning

confidence: 99%

“…The imaging protocol was based on optimal sequences reported in studies of human carotid arteries by surface MRI 4 and in investigations of tissue samples and animals in vivo by IVMRI. 5,6 Accordingly, the protocol consisted of a T1w spin-echo sequence (TR, 500 ms; TE, 13 ms), a moderately T2w fast-spin-echo sequence (TR, 2550 ms; TE, 50 ms; echo train length, 8), and a PDw fast-spin-echo sequence (TR, 2550 ms; TE, 12 ms; echo train length, 8). All ex vivo intravascular MRI was performed with a slice thickness of 2 mm and skip of 1 mm.…”

Section: Ivmri Coil and Ex Vivo Imaging Protocolmentioning

confidence: 99%

“…The iliac artery was imaged by use of the IVMRI coil with sequences similar to those used in the ex vivo studies. Black-blood imaging 7,8 was performed by applying a superior saturation pulse, because the standard double-inversion recovery technique resulted in too great a loss of efficiency and prolonged scan times for multislice acquisition. Fat saturation was abandoned after pilot experiments because of poor signal homogeneity induced by the presence of the metallic imaging wire.…”

Section: Imaging Of Human Iliac Arteries In Vivomentioning

confidence: 99%

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Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging

et al. 2005

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Background-Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies for plaque modification. Surface MRI can characterize tissue content of carotid but not deeper arteries. This study evaluated the usefulness of intravascular MRI (IVMRI) to discern the composition of human iliac arteries in vivo. Methods and Results-Initial studies validated IVMRI against histopathology of human atherosclerotic arteries ex vivo.A 0.030-inch-diameter IVMRI detector coil was advanced into isolated human aortoiliac arteries and coupled to a 1.5-T scanner. Information from combined T1-, moderate T2-, and proton-density-weighted images differentiated lipid, fibrous, and calcified components with favorable sensitivity and specificity and allowed accurate quantification of plaque size. The validated approach was then applied to image iliac arteries of 25 human subjects in vivo, and results were compared with those of intravascular ultrasound (IVUS). IVMRI readily visualized inner and outer plaque boundaries in all arteries, even those with extensive calcification that precluded IVUS interpretation. It also revealed the expected heterogeneity of atherosclerotic plaque content that was noted during ex vivo validation. Again, IVUS did not disclose this heterogeneity. The level of interobserver and intraobserver agreement in the interpretation of plaque composition was high for IVMRI but poor for IVUS. Conclusions-IVMRI can reliably identify plaque composition and size in arteries deep within the body. Identification of plaque components by IVMRI in vivo has important implications for the understanding and modification of human atherosclerosis.

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Section: Table 3 Clinical Characteristics Of the 25 Subjects In The mentioning

confidence: 99%

Section: Ivmri Coil and Ex Vivo Imaging Protocolmentioning

confidence: 99%

Section: Imaging Of Human Iliac Arteries In Vivomentioning

confidence: 99%

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Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging

et al. 2005

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“…CMR has successfully identified patients with thickened vascular walls of their coronary arteries [32•]. However, to image deeper vessels with high resolution, intravascular MRI coils have been developed [33]. Using existing imaging gradients and restricting the field of view by use of a receiver coil affixed to a catheter, resolutions on the order of 100 µm have been achieved [34].…”

Section: Myocardial Perfusion and Viabilitymentioning

confidence: 99%

Future prospects in cardiac magnetic resonance imaging

Doyle

Biederman²

2003

Curr Cardiol Rep

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To appreciate the impact that key developments will have on the future of cardiovascular magnetic resonance (CMR) imaging, it is instructive to consider its present status. CMR has passed the threshold of being used primarily by innovators, and is now in the early adopter stage. To reach this threshold has taken many years, but its adoption by early majority users is expected to accelerate the growth of CMR. A number of factors govern its natural growth potential, including physician education and credentialing, scanner availability, technology, and reimbursement policies. The intrinsic dimensional accuracy of CMR, coupled with its high level of reproducibility, make it ideal for inclusion in trials, potentially with dramatic reductions in trial duration and the number of subjects required. Clinically, there are a number of applications for which CMR is widely regarded as being the diagnostic test of choice. Software and hardware developments that speed up the basic CMR procedure are being incorporated into scanners, extending the functionality of routine applications such as flow imaging and tag visualization. Exciting areas that are close to routine application include coronary artery imaging, and evaluation of myocardial perfusion and viability status.

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“…Most of the research reporting the use of implanted coils concerned endoscopic MRI and was performed with catheter-based coils. Catheter-based coils can be made using classical RF coil schemes consisting of a rolled up conducting wire, using simple geometries [10,12,[14][15][16] or of a more complex forms [17][18][19][20][21], tuned with discrete capacitors. Dedicated microtechnological fabrication processes can also be used to improve the RF field pattern and provide better flexibility and mechanical properties [22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Implanted, inductively-coupled, radiofrequency coils fabricated on flexible polymeric material: Application to in vivo rat brain MRI at 7T

Ginefri

Rubin

Tatoulian

et al. 2012

Journal of Magnetic Resonance

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In Vivo Real-Time Intravascular MRI

Abstract: Real-time imaging with low-profile coil designs provides significant enhancements to intravascular MRI.

Cited by 24 publications

References 42 publications

Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging

Characterization of Human Atherosclerotic Plaques by Intravascular Magnetic Resonance Imaging

Future prospects in cardiac magnetic resonance imaging

Implanted, inductively-coupled, radiofrequency coils fabricated on flexible polymeric material: Application to in vivo rat brain MRI at 7T

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