In vivo quantitative whole‐brain T₁ rho MRI of multiple sclerosis

Abstract

T1ρ MRI demonstrates enhanced lesion contrast compared with T2 , and in some cases may provide complementary information. T1ρ may provide a useful measure of demyelinating processes in MS.

Automated detection of white matter and cortical lesions in early stages of multiple sclerosis

“…Thus, these previously proposed, automated methods seem to be infrequently used in clinical practice, where detecting new lesions, particularly of small size, is very important in diagnosis and follow‐up of MS patients. Moreover, most of this prior work has not been applied systematically to high‐resolution 3D MS acquisition protocols, which are increasingly utilized in clinical practice, nor to some other sequences that optimize the contrast of cortical lesions such as double‐inversion recovery (DIR), phase‐sensitive inversion recovery, and magnetization‐prepared 2 rapid acquisition gradient‐echo (MP2RAGE) …”

T1ρ relaxation time in brain regions increases with ageing: an experimental MRI observation in rats

“…It is expected that with the development of faster and more robust T1r techniques, T1r MR can be more widely applied in neuroimaging. 37,38,[45][46][47][48] In conclusion, an increase in T1r relaxation time was associated with age-related changes of the thalamus, hippocampus and frontal cortical regions of rat brain. A possible hypertensionrelated T1r increase in rat brain regions was also noted.…”

“…37,38 T1r values were measured in the user-defined regions of interest in the bilateral thalamus (T), hippocampus (H) and frontal cortices (C) from the T1r map of rat brains (Figures 2 and 3). The machinerelated scan-rescan T1r measurement stability for small animals has been established previously.…”

Differentiation of brain tumor-related edema based on 3D T1rho imaging

“…T1ρ has been studied to a limited extent in several neuroimaging applications including the evaluation of ischemia [11,23,24], neurodegenerative disorders [17,18], demyelinating disease [20,21], animal models of brain tumor [12–14,25], and response to gene therapy [15,16]. Although the exact mechanisms governing T1ρ relaxation are not fully understood, several factors proposed to influence T1ρ include scalar coupling, dipole–dipole interactions, and chemical exchange processes [26].…”

“…T1ρ can be used to probe macromolecular interactions and has been shown to reflect normal aging as well as pathologic changes in tissue protein and pH content [9–11]. A small number of published reports have shown potential applications of T1ρ neuroimaging to evaluate tumor boundaries [12–16], neurodegenerative disease [17–19], demyelination [20,21], psychiatric disease [22], and acute cerebral ischemia [11,23,24]. …”