Differentiation of brain tumor-related edema based on 3D T1rho imaging

Abstract

Background and purpose Cerebral edema associated with brain tumors is an important source of morbidity. Its type depends largely on the capillary ultra-structures of the histopathologic subtype of underlying brain tumor. The purpose of our study was to differentiate vasogenic edema associated with brain metastases and infiltrative edema related to diffuse gliomas using quantitative 3D T1 rho (T1ρ) imaging. Materials and methods Preoperative MR examination including whole brain 3D T1ρ imaging was performed in 23 patients with newly diagnosed brain tumors (9 with metastasis, 8 with lower grade glioma, LGG, 6 with glioblastoma, GBM). Mean T1ρ values were measured in regions of peritumoral non-enhancing T2 signal hyperintensity, excluding both enhancing and necrotic or cystic component, and normal-appearing white matter. Results Mean T1ρ values were significantly elevated in the vasogenic edema surrounding intracranial metastases when compared to the infiltrative edema associated with either LGG or GBM (p = 0.02 and < 0.01, respectively). No significant difference was noted between T1ρ values of infiltrative edema between LGG and GBM (p = 0.84 and 0.96, respectively). Conclusion Our study demonstrates the feasibility and potential diagnostic role of T1ρ in the quantitative differentiation between edema related to intracranial metastases and gliomas and as a potentially complementary tool to standard MR techniques in further characterizing pathophysiology of vasogenic and infiltrative edema.

T1ρ magnetic resonance fingerprinting

“…T 1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease . T 1ρ relaxation has also been shown to correlate with large molecules that tumble at low frequencies, including proteoglycans in ex vivo bovine and human cartilage experiments, demonstrating a decrease in T 1ρ relaxation time as the proteoglycan concentration decreases.…”

Bio‐SCOPE: fast biexponential T1ρ mapping of the brain using signal‐compensated low‐rank plus sparse matrix decomposition

“…[5][6][7][8] Therefore, brain T 1ρ mapping may provide early imaging biomarkers for various pathological processes, including Parkinson's disease, dementia, Alzheimer's disease, stroke, neoplasm, and multiple sclerosis. [9][10][11][12][13][14][15][16][17][18][19][20][21] T 1ρ relaxation is traditionally described in many in vivo tissues with a monoexponential decay model. 11,[22][23][24][25] However, recent studies have shown that T 1ρ relaxation has multiexponential components, especially biexponential components.…”

“…As a result, T 1 ρ imaging provides additional information about macromolecular changes compared with conventional T 1 and T 2 MRI . Therefore, brain T 1 ρ mapping may provide early imaging biomarkers for various pathological processes, including Parkinson's disease, dementia, Alzheimer's disease, stroke, neoplasm, and multiple sclerosis …”

Integrating multiple‐level molecular data to infer the distinctions between glioblastoma and lower‐grade glioma

“…To date, many studies have explored the distinction between GBM and LGG on multiple levels, including mutation, methylation, gene expression, imaging, clinical treatment and so on. Many positron emission tomography (PET)/single‐photon emission computed tomography (SPECT)/three‐dimensional (3D) T1rho imaging studies on brain tumors have explored the differential diagnosis between GBM and LGG . Previous studies have reported that the somatic intronic microsatellite loci differentiate between GBMs and LGGs .…”

“…Many positron emission tomography (PET)/single-photon emission computed tomography (SPECT)/three-dimensional (3D) T1rho imaging studies on brain tumors have explored the differential diagnosis between GBM and LGG. 7,8 Previous studies have reported that the somatic intronic microsatellite loci differentiate between GBMs and LGGs. 9 Reon et al 10 suggested that there were some differential long noncoding RNAs (lncRNAs) between GBMs and LGGs.…”