In vivo quantification of amygdala subnuclei using 4.7 T fast spin echo imaging

Aghamohammadi‐Sereshki, Arash; Huang, Yushan; Olsen, Fraser; Malykhin, Nikolai

doi:10.1016/j.neuroimage.2017.03.016

Cited by 9 publications

(24 citation statements)

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“…In this study, the location and orientation of the AG subnuclei corresponded to the classical definition of the AG (“V Class ”) (Brabec et al, ). However, due to lack of visible landmarks on MRI for delineation of the anterior AG from the periamygdaloid cortices (Aghamohammadi‐Sereshki et al, ; Allen et al, ), inclusion of some of the “V add ” (Brabec et al, ) tissue in our AG subnuclei segmentation method was inevitable. Therefore, our findings on age‐related sexual dimorphism are partially in agreement with Brabec et al ().…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, only the coronal plane was used to segment the AG into its five major subnuclei groups: the lateral (La) nucleus, the basal (B) nucleus, the accessory basal (AB) nucleus (these three nuclei form the basolateral group [BLA]), the cortical (Co) group, and the centromedial (CeM) group (Figure ). A single internal landmark line—which was either a horizontal line that connects the most medial border of the AG to the most lateral border of the AG or a diagonal line that connects the most inferomedial border of the AG to the most medio‐inferior border of the AG—was used to segment AG into the aforementioned subnuclei groups (Aghamohammadi‐Sereshki et al, ). Generally, consistent measurements of the AG subnuclei can be obtained by a person experienced in medial temporal lobe anatomy in 2 hr.…”

Section: Methodsmentioning

confidence: 99%

“…However, larger neuroimaging genetic studies might require the application of automated segmentation methods which might reduce the segmentation accuracy of the medial temporal lobe structures. The current manual segmentation protocol of the AG subnuclei is based on geometrical rules dependant on internal AG landmarks as the AG myelinated fibers are not visible even at 4.7 T FSE images (Aghamohammadi‐Sereshki et al, ). Therefore, our macroscopically defined AG subnuclei are only an approximation of the individual microscopical subnuclei.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

“…Therefore, the primary goal of this study was to investigate the nature of the AG subnuclei associations with age in a large sample of healthy individuals across the entire adult lifespan using recently developed ultra‐high‐resolution MRI volumetric method (Aghamohammadi‐Sereshki et al, ). Our second goal was to determine effects of APOE and BDNF polymorphisms on the AG and its subnuclei volumes.…”

Section: Introductionmentioning

confidence: 99%

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Amygdala subnuclei and healthy cognitive aging

Aghamohammadi‐Sereshki

Hrybouski

Travis

et al. 2018

Human Brain Mapping

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Amygdala is a group of nuclei involved in the neural circuits of fear, reward learning, and stress. The main goal of this magnetic resonance imaging (MRI) study was to investigate the relationship between age and the amygdala subnuclei volumes in a large cohort of healthy individuals. Our second goal was to determine effects of the apolipoprotein E (APOE) and brain‐derived neurotrophic factor (BDNF) polymorphisms on the amygdala structure. One hundred and twenty‐six healthy participants (18–85 years old) were recruited for this study. MRI datasets were acquired on a 4.7 T system. Amygdala was manually segmented into five major subdivisions (lateral, basal, accessory basal nuclei, and cortical, and centromedial groups). The BDNF (methionine and homozygous valine) and APOE genotypes (ε2, homozygous ε3, and ε4) were obtained using single nucleotide polymorphisms. We found significant nonlinear negative associations between age and the total amygdala and its lateral, basal, and accessory basal nuclei volumes, while the cortical amygdala showed a trend. These age‐related associations were found only in males but not in females. Centromedial amygdala did not show any relationship with age. We did not observe any statistically significant effects of APOE and BDNF polymorphisms on the amygdala subnuclei volumes. In contrast to APOE ε2 allele carriers, both older APOE ε4 and ε3 allele carriers had smaller lateral, basal, accessory basal nuclei volumes compared to their younger counterparts. This study indicates that amygdala subnuclei might be nonuniformly affected by aging and that age‐related association might be gender specific.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Limitations and Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amygdala subnuclei and healthy cognitive aging

Aghamohammadi‐Sereshki

Hrybouski

Travis

et al. 2018

Human Brain Mapping

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“…The amygdala is composed of different subnuclei with connections to the limbic system, as well as to the rest of the brain [9–12]. These are involved in reward learning, motivation, emotion, and several cognitive functions such as attention, perception, and explicit memory [10] (Fig.…”

Section: Introductionmentioning

confidence: 99%

Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia

Bocchetta

Iglesias

Cash

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with multiple genetic and pathological causes. It is characterized by both cortical and subcortical atrophies, with previous studies showing early involvement of the amygdala. However, no prior study has specifically investigated the atrophy of different subnuclei of the amygdala. Methods Using an automated segmentation tool for T1-weighted volumetric magnetic resonance imaging, we investigated amygdalar subnuclei (AS) involvement in a cohort of 132 patients with genetic or pathologically confirmed FTD (age: mean = 61 years (standard deviation = 8); disease duration: 5 (3) years) compared with 107 age-matched controls. Results AS were affected in all genetic and pathological forms of FTD. MAPT mutations/FTDP-17, Pick's disease, and transactive response DNA binding protein 43 kDa type C were the forms with the smallest amygdala (35%–50% smaller than controls in the most affected hemisphere, P < .0005). In most FTD groups, medial subnuclei (particularly the superficial, accessory basal and basal/paralaminar subnuclei) tended to be affected more than the lateral subnuclei, except for the progressive supranuclear palsy group, in which the corticoamygdaloid transition area was the least-affected area. Discussion Differential involvement of the AS was seen in the different genetic and pathological forms of FTD. In general, the most affected subnuclei were the superficial, accessory basal and basal/paralaminar subnuclei, which form part of a network of regions that control reward and emotion regulation, functions known to be particularly affected in FTD.

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Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Schlüter

Fraenz

Friedrich³

et al. 2022

Human Brain Mapping

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Neuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala's structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites.We, therefore, acquired brain images from 221 healthy participants using advanced multi-shell diffusion-weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high-resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO-PI-R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism-related disorders like depression.

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In vivo quantification of amygdala subnuclei using 4.7 T fast spin echo imaging

Cited by 9 publications

References 81 publications

Amygdala subnuclei and healthy cognitive aging

Amygdala subnuclei and healthy cognitive aging

Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

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