In Vivo Pulmonary Toxicity of Cellulose in Rats

Tátrai, Erzsébet; Brózik, Márta; Adamis, Z.; Merétey, K; Ungváry, G

doi:10.1002/(sici)1099-1263(199603)16:2<129::aid-jat316>3.0.co;2-c

Cited by 27 publications

(28 citation statements)

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“…Use of rat type I cell 40-kDa protein/type I cell alpha protein and human type I cell 56-kDa protein to quantify ATI cell necrosis in ALI Ultrastructural studies on injured lungs demonstrate that necrotic ATI cells are sloughed from their basement membranes into the airspaces [86][87][88]. Various experimental studies demonstrate that the amount of RTI 40 /TIa protein in distal airway fluid or bronchoalveolar lavage fluid (BALF) can be used to quantify the extent of ATI cell necrosis (table 2).…”

Section: Expression Of Alveolar Epithelial Type I Cell-selective Protmentioning

confidence: 99%

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair

McElroy

Kasper²

2004

European Respiratory Journal

115

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Ultrastructural studies demonstrate that alveolar epithelial type I cell damage is frequently observed in acute and chronic lung diseases.This article discusses the use of cell-selective proteins as markers for the investigation of injury and repair of the alveolar epithelium. The utility of proteins specific to alveolar epithelial type I cells as diagnostic markers of alveolar epithelial injury in acute lung injury is considered, and expression of proteins selective for alveolar epithelial type I cells in lungs following injury and in fibrosis are discussed. Eur Respir J 2004; 24: 664-673.

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Section: Expression Of Alveolar Epithelial Type I Cell-selective Protmentioning

confidence: 99%

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair

McElroy

Kasper²

2004

European Respiratory Journal

115

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“…Moreover, biocompatibility is not the only parameter to be investigated before the clinical applications of biomaterials. Within this context, the response of the immune system, as a key protective component of the organism, is of particular importance, as cellulose fibrils have lengthy bio-persistence in the body and thus may provoke immune reactions (Tatrai et al 1996;Muhle et al 1997;Dugan et al 2013;Lin and Dufresne 2014).…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility and immunomodulatory properties of wood based nanofibrillated cellulose

et al. 2014

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Cellulose nanofibrils (CNFs), unique and promising natural materials have gained significant attention recently for biomedical applications, due to their special biomechanical characteristics, surface chemistry, good biocompatibility and low toxicity. However, their long bio-persistence in the organism may provoke immune reactions and this aspect of CNFs has not been studied to date. Therefore, the aim of this work was to examine and compare the cytocompatibility and immunomodulatory properties of CNFs in vitro. CNFs (diameters of 10-70 nm; lengths of a few microns) were prepared from Norway spruce (Picea abies) by mechanical fibrillation and high pressure homogenisation. L929 cells, rat thymocytes or human peripheral blood mononuclear cells (PBMNCs) were cultivated with CNFs. None of the six concentrations of CNFs (31.25 µg/ml-1 mg/ml) induced cytotoxicity and oxidative stress in the L929 cells, nor induced necrosis and apoptosis of thymocytes and PBMNCs. Higher concentrations (250 µg/ml-1 mg/ml) slightly inhibited the metabolic activities of the L929 cells as a consequence of inhibited proliferation. The same concentrations of CNFs suppressed the proliferation of PBMNCs to phytohemaglutinine, a T-cell mitogen, and the process was followed by down-regulation of interleukin-2 (IL-2) and interferon-γ production. The highest concentration of CNFs inhibited IL-17A, but increased IL-10 and IL-6 production. The secretion of pro-inflammatory cytokines, IL-1β and tumor necrosis factor-α as well as Th2 cytokine (IL-4), remained unaltered. In conclusion, the results suggest that these CNFs are cytocompatible nanomaterial, according to current ISO criteria, with non-inflammatory and nonimmunogenic properties. Higher concentrations seem to be tolerogenic to the immune system, a characteristic very desirable for implantable biomaterials.

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“…Harrison et al noted that there exist surprisingly few data on cellulose despite the fact that this fiber is associated with products with rather wide commerical applications 3) . The few in vitro and in vivo experimental studies that have been conducted suggest that cellulose RFP may be biopersistent in the lung and may produce pulmonary inflammation [8][9][10] . Cullen and coworkers recently conducted a 3-week inhalation study with one form of cellulose RFP (i.e., mechanical wood pulp) at 1000 f/ml 11) .…”

Section: Cellulose Fibersmentioning

confidence: 99%

“…It is unclear whether the type of cellulose utilized in these studies is a representative form of cellulose that is widely used in the paper industry. In summary, the few in vitro and in vivo studies that have been Industrial Health 2001, 39, 119-125 conducted suggest that cellulose RFP may be biopersistent in the lung and may produce pulmonary inflammation [8][9][10][11] . Since cellulose represents a family of materials, there is a great need to assess the toxicity of the various respirable forms of this organic fiber-type.…”

Section: Cellulose Fibersmentioning

confidence: 99%

Man-Made Respirable-Sized Organic Fibers: What Do We Know about Their Toxicological Profiles?

2001

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Man-made organic fibers (MMOFs) have been manufactured for over 50 years. Until recently, there have been few concerns raised regarding the safety of organic fiber dusts. This is due, in large part, to the perception that the dimensions of most, if not all, of these products were too large to be inhaled into the distal lungs of workers, i.e., were considered to be nonrespirable. A brief review of some of the issues related to organic fiber toxicology is presented herein. Some of the organic fiber-types used in commerce are identified and some fundamental tenets of fiber toxicology are discussed. In addition, the European Union, in their recent consideration for banning chrysotile asbestos fibers, evaluated some organic fiber substitutes and compared them to the hazards of asbestos. A brief review of their conclusions is described below. Finally, the results of some recent studies assessing the mechanisms of biodegradability of para-aramid respirable-sized, fiber-shaped particulates (RFP) are presented. Para-aramid (p-aramid) RFP are the most extensively-studied respirable organic fiber-type and RFP is the new term which describes respirable-sized organic fibers (ECETOC, 1996) (1). The results of these studies provide clues regarding the mechanism(s) of p-aramid RFP shortening in the lungs of exposed animals, and may be relevant for humans.

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In Vivo Pulmonary Toxicity of Cellulose in Rats

Cited by 27 publications

References 0 publications

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair

Cytocompatibility and immunomodulatory properties of wood based nanofibrillated cellulose

Man-Made Respirable-Sized Organic Fibers: What Do We Know about Their Toxicological Profiles?

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